Search Results - "P Pogribny, Igor"

Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma by Pogribny, Igor P, Rusyn, Ivan

“…Abstract Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers in humans. The molecular mechanisms leading to the development of HCC…”
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Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review by Chappell, Grace, Pogribny, Igor P., Guyton, Kathryn Z., Rusyn, Ivan

“…Accumulating evidence suggests that epigenetic alterations play an important role in chemically-induced carcinogenesis. Although the epigenome and genome may…”
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Considering maternal dietary modulators for epigenetic regulation and programming of the fetal epigenome by Chango, Abalo, Pogribny, Igor P

“…Fetal life is characterized by a tremendous plasticity and ability to respond to various environmental and lifestyle factors, including maternal nutrition…”
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E‐cadherin transcriptional down‐regulation by epigenetic and microRNA‐200 family alterations is related to mesenchymal and drug‐resistant phenotypes in human breast cancer cells by Tryndyak, Volodymyr P., Beland, Frederick A., Pogribny, Igor P.

“…The conversion of early stage tumors into invasive malignancies with an aggressive phenotype has been associated with the irreversible loss of E‐cadherin…”
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DNA hypomethylation in the origin and pathogenesis of human diseases by Pogribny, Igor P, Beland, Frederick A

“…The pathogenesis of any given human disease is a complex multifactorial process characterized by many biologically significant and interdependent alterations…”
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Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin by Kovalchuk, Olga, Filkowski, Jody, Meservy, James, Ilnytskyy, Yaroslav, Tryndyak, Volodymyr P, Chekhun, Vasyl' F, Pogribny, Igor P

“…Many chemotherapy regiments are successfully used to treat breast cancer; however, often breast cancer cells develop drug resistance that usually leads to a…”
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The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma by Uehara, Takeki, Pogribny, Igor P, Rusyn, Ivan

“…Human hepatocellular carcinoma (HCC) develops most often as a complication of fibrosis or cirrhosis. While most human studies of HCC provide crucial insights…”
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Genotoxic and Epigenotoxic Alterations in the Lung and Liver of Mice Induced by Acrylamide: A 28 Day Drinking Water Study by de Conti, Aline, Tryndyak, Volodymyr, VonTungeln, Linda S, Churchwell, Mona I, Beland, Frederick A, Antunes, Alexandra M. M, Pogribny, Igor P

“…Acrylamide has been classified as a “Group 2A carcinogen” (probably carcinogenic to humans) by the International Agency for Research on Cancer. The…”
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Gene Expression and DNA Methylation Alterations in the Glycine N-Methyltransferase Gene in Diet-Induced Nonalcoholic Fatty Liver Disease-Associated Carcinogenesis by Borowa-Mazgaj, Barbara, de Conti, Aline, Tryndyak, Volodymyr, Steward, Colleen R, Jimenez, Leandro, Melnyk, Stepan, Seneshaw, Mulugeta, Mirshahi, Faridodin, Rusyn, Ivan, Beland, Frederick A, Sanyal, Arun J, Pogribny, Igor P

“…Abstract Nonalcoholic fatty liver disease (NAFLD) is becoming a major etiological risk factor for hepatocellular carcinoma (HCC) in the United States and other…”
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Role of ferritin alterations in human breast cancer cells by Shpyleva, Svitlana I, Tryndyak, Volodymyr P, Kovalchuk, Olga, Starlard-Davenport, Athena, Chekhun, Vasyl' F, Beland, Frederick A, Pogribny, Igor P

“…Breast cancer is the most common malignancy in women. Successful treatment of breast cancer relies on a better understanding of the molecular mechanisms…”
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Butyrate-containing structured lipids act on HDAC4, HDAC6, DNA damage and telomerase activity during promotion of experimental hepatocarcinogenesis by Ortega, Juliana Festa, Heidor, Renato, Auriemo, Ana Paula, Marques Affonso, Juliana, Pereira D’ Amico, Thais, Herz, Corinna, de Conti, Aline, Ract, Juliana, Gioieli, Luiz Antônio, Purgatto, Eduardo, Lamy, Evelyn, P. Pogribny, Igor, Salvador Moreno, Fernando

“…Abstract Hepatocellular carcinoma (HCC) presents with a high treatment resistance and poor prognosis. Early diagnosis and preventive approaches such as…”
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Cerebellar oxidative DNA damage and altered DNA methylation in the BTBR T+tf/J mouse model of autism and similarities with human post mortem cerebellum by Shpyleva, Svitlana, Ivanovsky, Samuil, de Conti, Aline, Melnyk, Stepan, Tryndyak, Volodymyr, Beland, Frederick A, James, S Jill, Pogribny, Igor P

“…The molecular pathogenesis of autism is complex and involves numerous genomic, epigenomic, proteomic, metabolic, and physiological alterations. Elucidating and…”
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Epigenetic effects of low-level sodium arsenite exposure on human liver HepaRG cells by Tryndyak, Volodymyr P., Borowa-Mazgaj, Barbara, Steward, Colleen R., Beland, Frederick A., Pogribny, Igor P.

“…Chronic exposure to inorganic arsenic is associated with a variety of adverse health effects, including lung, bladder, kidney, and liver cancer. Several…”
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MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis by de Conti, Aline, Ortega, Juliana Festa, Tryndyak, Volodymyr, Dreval, Kostiantyn, Moreno, Fernando Salvador, Rusyn, Ivan, Beland, Frederick A, Pogribny, Igor P

“…Hepatocellular carcinoma (HCC) is the fastest-rising cause of cancer-related death in the United States. Recent epidemiological studies have identified…”
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Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet by Tryndyak, Volodymyr P., Willett, Rose A., Avigan, Mark I., Sanyal, Arun J., Beland, Frederick A., Rusyn, Ivan, Pogribny, Igor P.

“…Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver disease, and patient susceptibility to its onset and progression is influenced by…”
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MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis by Kindrat, Iryna, Tryndyak, Volodymyr, de Conti, Aline, Shpyleva, Svitlana, Mudalige, Thilak K, Kobets, Tetyana, Erstenyuk, Anna M, Beland, Frederick A, Pogribny, Igor P

“…Over-expression of transferrin receptor 1 (TFRC) is observed in hepatocellular carcinoma (HCC); however, there is a lack of conclusive information regarding…”
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Gene Expression and DNA Methylation Alterations During Non-alcoholic Steatohepatitis-Associated Liver Carcinogenesis by Dreval, Kostiantyn, Tryndyak, Volodymyr, de Conti, Aline, Beland, Frederick A, Pogribny, Igor P

“…Hepatocellular carcinoma (HCC) is one of the most aggressive human cancers. HCC is characterized by an acquisition of multiple abnormal phenotypes driven by…”
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Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location by Yauk, Carole, Polyzos, Aris, Rowan-Carroll, Andrea, Somers, Christopher M, Godschalk, Roger W, Van Schooten, Frederik J, Berndt, M. Lynn, Pogribny, Igor P, Koturbash, Igor, Williams, Andrew, Douglas, George R, Kovalchuk, Olga

“…Particulate air pollution is widespread, yet we have little understanding of the long-term health implications associated with exposure. We investigated DNA…”
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Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis by Uehara, Takeki, Ainslie, Garrett R, Kutanzi, Kristi, Pogribny, Igor P, Muskhelishvili, Levan, Izawa, Takeshi, Yamate, Jyoji, Kosyk, Oksana, Shymonyak, Svitlana, Bradford, Blair U, Boorman, Gary A, Bataller, Ramon, Rusyn, Ivan

“…Hepatocellular carcinoma (HCC) mostly develops in patients with advanced fibrosis; however, the mechanisms of interaction between a genotoxic insult and…”
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Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet by Tryndyak, Volodymyr P., Ross, Sharon A., Beland, Frederick A., Pogribny, Igor P.

“…Altered expression of microRNAs (miRNAs) has been reported in diverse human cancers; however, the down‐regulation or up‐regulation of any particular miRNAs in…”
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