Search Results - "Pınar Mega Tiber"

In vitro and in silico investigations of the pro-apoptotic activity of Opuntia ficus-indica cladode extracts against K562 cells by Öncül, Şule, Becer, Eda, Mega Tiber, Pınar, Teralı, Kerem, Aykac, Asli

“…Cladodes of Opuntia ficus-indica (OFI) are thought to be an excellent source of bioactive compounds, making them an aspirant for the manufacture of…”
Get full text

3-Pyridinylboronic Acid Ameliorates Rotenone-Induced Oxidative Stress Through Nrf2 Target Genes in Zebrafish Embryos by Üstündağ, Fümet Duygu, Ünal, İsmail, Üstündağ, Ünsal Veli, Cansız, Derya, Beler, Merih, Karagöz, Atakan, Kara Subaşat, Hülya, Alturfan, A. Ata, Mega Tiber, Pınar, Emekli-Alturfan, Ebru

“…Parkinson’s disease (PD) is one of the most common forms of neurodegenerative diseases and research on potential therapeutic agents for PD continues. Rotenone…”
Get full text

Synthesis and Evaluation of Novel Metacetamol Derivatives with Hydrazone Moiety as Anticancer and Antimicrobial Agents by Şenkardeş, Sevil, Atlıhan, İrem, Çayır, Elif, Mega Tiber, Pınar, Orun, Oya, Nigiz, Şeyma, Özkul, Ceren, Gündüz, Miyase Gözde, Küçükgüzel, Ş. Güniz

“…By exploiting the wide biological potential of the hydrazone scaffold, a series of hydrazone derivatives were synthesized, starting from…”
Get full text

Synthesis of Tolmetin Hydrazide-Hydrazones and Discovery of a Potent Apoptosis Inducer in Colon Cancer Cells by Küçükgüzel, Ş. Güniz, Koç, Derya, Çıkla-Süzgün, Pelin, Özsavcı, Derya, Bingöl-Özakpınar, Özlem, Mega-Tiber, Pınar, Orun, Oya, Erzincan, Pınar, Sağ-Erdem, Safiye, Şahin, Fikrettin

“…Tolmetin hydrazide and a novel series of tolmetin hydrazide–hydrazones 4a–l were synthesized in this study. The structures of the new compounds were determined…”
Get full text

The interactions of human ovarian cancer cells and nanotextured surfaces: cell attachment, viability and apoptosis studies by Ya ayan, Gökçen, Orun, Oya, Mega Tiber, P nar, Ro man, Veronika, Koçyi it Sevinç, Sevgi

“…Understanding cell responses to the topography they are interacting with has a key role in designing surfaces due to the distinctiveness in the responses of…”
Get full text

Expression of cardiac inwardly rectifying potassium channels in pentylenetetrazole kindling model of epilepsy in rats by Akyüz, Enes, Mega Tiber, Pınar, Beker, Merve, Akbaş, Fahri

“…Clinical and experimental studies show that epilepsy affects cardiac function; however, the underlying molecular mechanism has not been fully elucidated…”
Get full text

Chromatin modifications of hTERT gene in hTERT-immortalized human mesenchymal stem cells upon exposure to radiation by Serakinci, Nedime, Mega Tiber, Pınar, Orun, Oya

“…Regulation of telomerase activity is thought to participate in the cellular response to ionizing radiation. Epigenetic mechanisms play a role in this…”
Get full text

Doxorubicin hydrochloride loaded nanotextured films as a novel drug delivery platform for ovarian cancer treatment by Yaşayan, Gökçen, Mega Tiber, Pınar, Orun, Oya, Alarçin, Emine

“…An approach for cancer treatment is modulation of tumor microenvironment. Based on the role of extracellular matrix in cell modulation, fabrication of textured…”
Get full text

The role of the PTEN/mTOR axis in clinical response of rectal cancer patients by Orun, Oya, Özden, Sevgi, Kılınç, Olca, Mega Tiber, Pınar, Yonar, Pelin, Özgen, Zerrin, Özyurt, Hazan

“…Background Preoperative chemoradiotherapy has long been accepted as a method to improve survival and lifetime quality of rectal cancer patients. However,…”
Get full text

Expression of TRF2 and its prognostic relevance in advanced stage cervical cancer patients by Ozden, Sevgi, Tiber, Pinar Mega, Ozgen, Zerrin, Ozyurt, Hazan, Serakinci, Nedime, Orun, Oya

“…Telomeres are protective caps consisted of specific tandem repeats (5'-TTAGGG-3'). Shortening of telomeres at each cell division is known as "mitotic clock" of…”
Get full text

Determination of spatial proximity between the N-terminus and cocaine binding site of the dopamine transporter by FRET by Orun, Oya, Mega Tiber, Pınar

Get full text

The association of apoptotic protein expressions sensitive to apoptosis gene, p73 and p53 with the prognosis of cervical carcinoma by Mega Tiber, Pinar, Baloglu, Latife, Ozden, Sevgi, Ozgen, Zerrin, Ozyurt, Hazan, Eren, Makbule, Orun, Oya

“…To evaluate the expressions of several apoptotic pathway proteins in relation to clinical parameters and survival in patients with cervical carcinoma. A total…”
Get full text

Synthesis and molecular modeling of MetAP2 of thiosemicarbazides, 1,2,4-triazoles, thioethers derived from (S)-Naproxen as possible breast cancer agents by Birgül, Kaan, Uba, Abdullah Ibrahim, Çuhadar, Ozan, Sevinç, Sevgi Koçyiğit, Tiryaki, Selen, Tiber, Pınar Mega, Orun, Oya, Telci, Dilek, Yılmaz, Özgür, Yelekçi, Kemal, Güniz Küçükgüzel, Ş.

“…•We synthesized new (S)-Naproxen derivatives.•We investigated their anticancer activity and apoptotic effect.•Some compounds exhibited strong inhibition…”
Get full text

Morphine ameliorates pentylenetetrazole-induced locomotor pattern in zebrafish embryos; mechanism involving regulation of opioid receptors, suppression of oxidative stress, and inflammation in epileptogenesis by Üstündağ, Fümet Duygu, Ünal, İsmail, Üstündağ, Ünsal Veli, Cansız, Derya, Beler, Merih, Alturfan, A. Ata, Tiber, Pınar Mega, Emekli-Alturfan, Ebru

“…Zebrafish (Danio rerio) is becoming an increasingly important model in epilepsy research. Pentylenetetrazole (PTZ) is a convulsant agent that induces epileptic…”
Get full text

3-Pyridinylboronic acid normalizes the effects of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in zebrafish embryos by Üstündağ, Fümet Duygu, Ünal, İsmail, Cansız, Derya, Üstündağ, Ünsal Veli, Subaşat, Hülya Kara, Alturfan, A. Ata, Tiber, Pınar Mega, Emekli-Alturfan, Ebru

“…1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that damages dopaminergic neurons. Zebrafish has been shown to be a suitable model organism…”
Get full text

Anti-Cancer Acitivity of Etodolac and Its Derivatives on Prostate and Colorectal Cancer Cell Lines by Sevgi Koçyiğit Sevinç, Oya Orun, Pınar Mega Tiber, Pelin Çıkla-Süzgün, Ş. Güniz Küçükgüzel

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used as anti-inflammatory and analgesic agents. This family of drugs suppresses prostaglandin…”
Get full text

Synthesis of pro-apoptotic indapamide derivatives as anticancer agents by Yılmaz, Özgür, Özbaş Turan, Suna, Akbuğa, Jülide, Tiber, Pınar Mega, Orun, Oya, Supuran, Claudiu T, Küçükgüzel, Ş Güniz

“…4-Chloro-3-({[(substitutedamino)carbonothioyl]amino}sulfonyl)-N-(2-methyl-2,3-dihydro-1H-indole-1-yl)benzamide (1-20) and…”
Get more information

Biological effects of whole Z.Officinale extract on chronic myeloid leukemia cell line K562 by Mega Tiber, Pinar, Kocyigit Sevinc, Sevgi, Kilinc, Olca, Orun, Oya

“…The anticancer activity of Zingiber officinalis (ginger) is an area of active research. However, data is quite limited regarding its action and mechanism,…”
Get full text

Investigation of the Association Between Dopamine D1 Receptor Gene Polymorphisms and Essential Hypertension in a Group of Turkish Subjects by Orun, Oya, Nacar, Cevdet, Cabadak, Hülya, Tiber, P nar Mega, Do an, Yüksel, Güneysel, Özlem, Fak, Ali Serdar, Kan, Beki

“…Dopamine has been shown to influence blood pressure by regulating renal sodium excretion through direct interaction with the dopamine receptors, especially…”
Get full text

FRET-based characterization of K264A, D345A, and Y335Amutants in the human dopamine transporter by ORUN, Oya, MEGA TİBER, Pınar

Get full text