Search Results - "Püschl, Ask"

Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004 by Hvenegaard, Mette G, Bang-Andersen, Benny, Pedersen, Henrik, Jørgensen, Morten, Püschl, Ask, Dalgaard, Lars

“…1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]-piperazine (Lu AA21004) is a novel antidepressant that is currently in late-stage clinical development for major…”
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Target-Mediated Brain Tissue Binding for Small Molecule Inhibitors of Heat Shock Protein 90 by Badolo, Lassina, Thirstrup, Kenneth, Nielsen, Søren Møller, Püschl, Ask, Jensen, Thomas, Watson, Steve, Bundgaard, Christoffer

“…Drug distribution in the brain is generally associated with an affinity for fatty brain tissues and therefore known to be species- and…”
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Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for α(1)-adrenoceptors by Kristensen, Jesper L, Püschl, Ask, Jensen, Martin, Risgaard, Rune, Christoffersen, Claus T, Bang-Andersen, Benny, Balle, Thomas

“…A series of 1-(10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methylpiperazine analogues substituted in the 8-position of the 10,11-dihydrodibenzo[b,f]thiepine…”
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Synthesis and SAR study of a novel series of dopamine receptor agonists by Risgaard, Rune, Jensen, Martin, Jørgensen, Morten, Bang-Andersen, Benny, Christoffersen, Claus T., Jensen, Klaus G., Kristensen, Jesper L., Püschl, Ask

“…The synthesis of a novel series of dopamine receptor agonists are described as well as their in vitro potency and efficacy on dopamine D1 and D2 receptors…”
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Exploring the Neuroleptic Substituent in Octoclothepin: Potential Ligands for Positron Emission Tomography with Subnanomolar Affinity for α1-Adrenoceptors by Kristensen, Jesper L, Püschl, Ask, Jensen, Martin, Risgaard, Rune, Christoffersen, Claus T, Bang-Andersen, Benny, Balle, Thomas

“…A series of 1-(10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methylpiperazine analogues substituted in the 8-position of the 10,11-dihydrodibenzo[b,f]thiepine…”
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2‘-O-[2-(Guanidinium)ethyl]-Modified Oligonucleotides:  Stabilizing Effect on Duplex and Triplex Structures by Prakash, Thazha P, Püschl, Ask, Lesnik, Elena, Mohan, Venkatraman, Tereshko, Valentina, Egli, Martin, Manoharan, Muthiah

“…Oligonucleotides with a novel 2‘-O-[2-(guanidinium)ethyl] (2‘-O-GE) modification have been synthesized using a novel protecting group strategy for the…”
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Radiolabelling and PET brain imaging of the α1 -adrenoceptor antagonist Lu AE43936 by Risgaard, Rune, Ettrup, Anders, Balle, Thomas, Dyssegaard, Agnete, Hansen, Hanne Demant, Lehel, Szabolcs, Madsen, Jacob, Pedersen, Henrik, Püschl, Ask, Badolo, Lassina, Bang-Andersen, Benny, Knudsen, Gitte Moos, Kristensen, Jesper Langgaard

“…Abstract Cerebral α1 -adrenoceptors are a common target for many antipsychotic drugs. Thus, access to positron emission tomography (PET) brain imaging of α1…”
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Exploring the Neuroleptic Substituent in Octoclothepin: Potential Ligands for Positron Emission Tomography with Subnanomolar Affinity for α 1 -Adrenoceptors by Kristensen, Jesper L., Püschl, Ask, Jensen, Martin, Risgaard, Rune, Christoffersen, Claus T., Bang-Andersen, Benny, Balle, Thomas

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Pyrrolidine PNA:  A Novel Conformationally Restricted PNA Analogue by Püschl, Ask, Tedeschi, Tullia, Nielsen, Peter E

“…A new conformationally restricted PNA adenine monomer has been synthesized in 13 steps from cis-4-hydroxy-d-proline. A fully modified adenine decamer displayed…”
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Peptide nucleic acids (PNAs) with a functional backbone by Püschl, Ask, Sforza, Stefano, Haaima, Gerald, Dahl, Otto, Nielsen, Peter E.

“…The synthesis of 10 new T-PNA monomers derived from L-amino acids is presented. The monomers were incorporated into decameric PNA oligomers, and the…”
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N,N′-Bis-(2-(cyano)ethoxycarbonyl)-2-methyl-2-thiopseudourea: A Guanylating Reagent for Synthesis of 2′-O-[2-(Guanidinium)ethyl]-Modified Oligonucleotides by Prakash, Thazha P., Püschl, Ask, Manoharan, Muthiah

“…A guanylating reagent, N,N′-bis-(2-(cyano)ethoxycarbonyl)-2-thiopseudourea, was synthesized and used for synthesis of 2′-O-[2-(guanidinium)ethyl] (2′-O-GE)…”
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Synthesis of Pyrrolidinone PNA:  A Novel Conformationally Restricted PNA Analogue by Püschl, Ask, Boesen, Thomas, Zuccarello, Guido, Dahl, Otto, Pitsch, Stefan, Nielsen, Peter E

“…To preorganize PNA for duplex formation, a new cyclic pyrrolidinone PNA analogue has been designed. In this analogue the aminoethylglycine backbone and the…”
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Structure of red and orange fluorescein by Anthoni, Uffe, Christophersen, Carsten, Nielsen, Per H., Püschl, Ask, Schaumburg, Kjeld

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Solid phase synthesis of oligodeoxynucleoside phosphorodithioates by a phosphotriester method using a chemoselective coupling reagent by Kehler, Jan, Püschl, Ask, Dahl, Otto

“…A phosphotriester method has been developed for solid phase synthesis of oligodeoxynucleoside phosphorodithioates. Couplings are performed by chemoselective…”
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