Search Results - "Pöverlein, Christoph"

G Protein-Coupled Receptor 119 (GPR119) Agonists for the Treatment of Diabetes: Recent Progress and Prevailing Challenges by Ritter, Kurt, Buning, Christian, Halland, Nis, Pöverlein, Christoph, Schwink, Lothar

“…In this Perspective, recent advances and challenges in the development of GPR119 agonists as new oral antidiabetic drugs will be discussed. Such agonists are…”
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Total Synthesis of GE81112A: An Orthoester-Based Approach by Fayad, Scherin, Jafari, Ardalan, Schuler, Sören M. M., Kurz, Michael, Plettenburg, Oliver, Hammann, Peter E., Bauer, Armin, Jürjens, Gerrit, Pöverlein, Christoph

“…The GE81112 series, consisting of three naturally occurring tetrapeptides and synthetic derivatives, is evaluated as a potential lead structure for the…”
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Genomic and Chemical Decryption of the Bacteroidetes Phylum for Its Potential to Biosynthesize Natural Products by Brinkmann, Stephan, Kurz, Michael, Patras, Maria A, Hartwig, Christoph, Marner, Michael, Leis, Benedikt, Billion, André, Kleiner, Yolanda, Bauer, Armin, Toti, Luigi, Pöverlein, Christoph, Hammann, Peter E, Vilcinskas, Andreas, Glaeser, Jens, Spohn, Marius, Schäberle, Till F

“…With progress in genome sequencing and data sharing, 1,000s of bacterial genomes are publicly available. Genome mining-using bioinformatics tools in terms of…”
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Total Synthesis of Floyocidin B: 4,5-Regioselective Functionalization of 2-Chloropyridines by Kleiner, Yolanda, Bauer, Armin, Hammann, Peter, Schuler, Sören M. M., Pöverlein, Christoph

“…The recently discovered natural product (NP) (+)-floyocidin B with antimicrobial activity against Mycobacterium tuberculosis displays a hitherto unknown…”
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Full Profiling of GE81112A, an Underexplored Tetrapeptide Antibiotic with Activity against Gram-Negative Pathogens by Schuler, Sören M M, Jürjens, Gerrit, Marker, Alexander, Hemmann, Ulrike, Rey, Astrid, Yvon, Stéphane, Lagrevol, Marjorie, Hamiti, Mohamed, Nguyen, Fabian, Hirsch, Rolf, Pöverlein, Christoph, Vilcinskas, Andreas, Hammann, Peter, Wilson, Daniel N, Mourez, Michael, Coyne, Sebastien, Bauer, Armin

“…After the first total synthesis combined with structure revision, we performed thorough and profiling of the underexplored tetrapeptide GE81112A. From the…”
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Tuning Diketodioxinone Reactivity: Biomimetic Synthesis of the Resorcylate Antibiotic Fungal Metabolites ent-W1278A, -B, and -C, Using Iterative Aromatization Reactions by Navarro, Ismael, Pöverlein, Christoph, Schlingmann, Gerhard, Barrett, Anthony G. M

“…The onset temperature of the retro-Diels−Alder reactions of diketo-1,3-dioxin-2-ones to generate α,γ,ε-triketo-ketenes was found to be significantly reduced…”
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Synthetic Studies towards Radicicol through Biomimetic Macrolactonization and Transannular Aromatization Reactions by Cookson, Rosa, Pöverlein, Christoph, Lachs, Jennifer, Barrett, Anthony G. M.

“…Studies towards the total synthesis of the natural product radicicol are described that employ a late‐stage esterification and aromatization by trapping a…”
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Triantennary GalNAc Molecular Imaging Probes for Monitoring Hepatocyte Function in a Rat Model of Nonalcoholic Steatohepatitis by Mishra, Anurag, Castañeda, Tamara R., Bader, Erik, Elshorst, Bettina, Cummings, Sheila, Scherer, Petra, Bangari, Dinesh S., Loewe, Claudia, Schreuder, Herman, Pöverlein, Christoph, Helms, Mike, Jones, Seth, Zech, Gernot, Licher, Thomas, Wagner, Michael, Schudok, Manfred, Hoop, Meltsje, Plowright, Alleyn T., Atzrodt, Jens, Kannt, Aimo, Laitinen, Iina, Derdau, Volker

“…Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease that can lead to irreversible liver cirrhosis and cancer. Early…”
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Photoredox‐Mediated Hydrogen Isotope Exchange Reactions of Amino‐Acids, Peptides, and Peptide‐Derived Drugs by Legros, Fabien, Fernandez‐Rodriguez, Patricia, Mishra, Anurag, Weck, Remo, Bauer, Armin, Sandvoss, Martin, Ruf, Sven, Méndez, María, Mora‐Radó, Helena, Rackelmann, Nils, Pöverlein, Christoph, Derdau, Volker

“…Hydrogen isotopically labelled compounds are essential diagnostic tools in drug research and development, as they provide vital information about the…”
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Total Synthesis and Structure Revision of (-)-Avicennone C by Kleiner, Yolanda, Hammann, Peter, Becker, Jonathan, Bauer, Armin, Pöverlein, Christoph, Schuler, Sören M M

“…All four possible stereoisomers of the natural product (-)-avicennone C were synthesized using two different methods for ring closure. The absolute…”
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Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin by Couturier, Cédric, Groß, Sebastian, Tesmar, Alexander, Hoffmann, Judith, Deckarm, Selina, Fievet, Anouchka, Dubarry, Nelly, Taillier, Thomas, Pöverlein, Christoph, Stump, Heike, Kurz, Michael, Toti, Luigi, Haag Richter, Sabine, Schummer, Dietmar, Sizun, Philippe, Hoffmann, Michael, Prasad Awal, Ram, Zaburannyi, Nestor, Harmrolfs, Kirsten, Wink, Joachim, Lessoud, Emilie, Vermat, Thierry, Cazals, Veronique, Silve, Sandra, Bauer, Armin, Mourez, Michael, Fraisse, Laurent, Leroi‐Geissler, Corinne, Rey, Astrid, Versluys, Stéphanie, Bacqué, Eric, Müller, Rolf, Renard, Stephane

“…Herein, we describe the myxobacterial natural product Corramycin isolated from Corallococcus coralloides. The linear peptide structure contains an…”
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Total Synthesis and Structural Revision of the Antibiotic Tetrapeptide GE81112A by Jürjens, Gerrit, Schuler, Sören M. M., Kurz, Michael, Petit, Sylvain, Couturier, Cédric, Jeannot, Frédéric, Nguyen, Fabian, Wende, Raffael C., Hammann, Peter E., Wilson, Daniel N., Bacqué, Eric, Pöverlein, Christoph, Bauer, Armin

“…The total synthesis of the naturally occurring antibiotic GE81112A, a densely functionalized tetrapeptide, is reported. Comparison of spectral data with those…”
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The Discovery and Structure‐Activity Evaluation of (+)‐Floyocidin B and Synthetic Analogs by Kleiner, Yolanda, Pöverlein, Christoph, Klädtke, Jannike, Kurz, Michael, König, Henrik F., Becker, Jonathan, Mihajlovic, Sanja, Zubeil, Florian, Marner, Michael, Vilcinskas, Andreas, Schäberle, Till F., Hammann, Peter, Schuler, Sören M. M., Bauer, Armin

“…Tuberculosis represents one of the ten most common courses of death worldwide and the emergence of multidrug‐resistant M. tuberculosis makes the discovery of…”
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Nanomolar inhibitors of Mycobacterium tuberculosis glutamine synthetase 1: Synthesis, biological evaluation and X-ray crystallographic studies by Couturier, Cédric, Silve, Sandra, Morales, Renaud, Pessegue, Bernard, Llopart, Sylvie, Nair, Anil, Bauer, Armin, Scheiper, Bodo, Pöverlein, Christoph, Ganzhorn, Axel, Lagrange, Sophie, Bacqué, Eric

“…We have identified by high throughput screening and then optimized a series of imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one that potently inhibit M. tuberculosis…”
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Diels−Alder Reactions of Oroidin and Model Compounds by Pöverlein, Christoph, Breckle, Gregor, Lindel, Thomas

“…It is shown that the marine key metabolite oroidin undergoes Diels−Alder reactions with electron-poor dienophiles. However, on heating of oroidin in the…”
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Strukturaufklärung, Totalsynthese, In‐Vivo‐Aktivität und Potentieller Biosyntheseweg des Neuen Myxobakteriellen Antibiotikums Corramycin by Couturier, Cédric, Groß, Sebastian, von Tesmar, Alexander, Hoffmann, Judith, Deckarm, Selina, Fievet, Anouchka, Dubarry, Nelly, Taillier, Thomas, Pöverlein, Christoph, Stump, Heike, Kurz, Michael, Toti, Luigi, Haag Richter, Sabine, Schummer, Dietmar, Sizun, Philippe, Hoffmann, Michael, Prasad Awal, Ram, Zaburannyi, Nestor, Harmrolfs, Kirsten, Wink, Joachim, Lessoud, Emilie, Vermat, Thierry, Cazals, Veronique, Silve, Sandra, Bauer, Armin, Mourez, Michael, Fraisse, Laurent, Leroi‐Geissler, Corinne, Rey, Astrid, Versluys, Stéphanie, Bacqué, Eric, Müller, Rolf, Renard, Stephane

“…Abstract Im Folgenden beschreiben wir das aus dem Myxobakterium Corallococcus coralloides isolierte Antibiotikum Corramycin. Die lineare Peptidstruktur enthält…”
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Totalsynthese und Strukturkorrektur des antibiotisch wirksamen Tetrapeptids GE81112A by Jürjens, Gerrit, Schuler, Sören M. M., Kurz, Michael, Petit, Sylvain, Couturier, Cédric, Jeannot, Frédéric, Nguyen, Fabian, Wende, Raffael C., Hammann, Peter E., Wilson, Daniel N., Bacqué, Eric, Pöverlein, Christoph, Bauer, Armin

“…Die erste Totalsynthese des antibiotisch wirksamen Naturstoffs GE81112A, eines hoch funktionalisierten Tetrapeptids, wurde abgeschlossen. Der Vergleich der…”
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Strukturaufklärung, Totalsynthese, In‐Vivo‐Aktivität und Potentieller Biosyntheseweg des Neuen Myxobakteriellen Antibiotikums Corramycin by Couturier, Cédric, Groß, Sebastian, Tesmar, Alexander, Hoffmann, Judith, Deckarm, Selina, Fievet, Anouchka, Dubarry, Nelly, Taillier, Thomas, Pöverlein, Christoph, Stump, Heike, Kurz, Michael, Toti, Luigi, Haag Richter, Sabine, Schummer, Dietmar, Sizun, Philippe, Hoffmann, Michael, Prasad Awal, Ram, Zaburannyi, Nestor, Harmrolfs, Kirsten, Wink, Joachim, Lessoud, Emilie, Vermat, Thierry, Cazals, Veronique, Silve, Sandra, Bauer, Armin, Mourez, Michael, Fraisse, Laurent, Leroi‐Geissler, Corinne, Rey, Astrid, Versluys, Stéphanie, Bacqué, Eric, Müller, Rolf, Renard, Stephane

“…Im Folgenden beschreiben wir das aus dem Myxobakterium Corallococcus coralloides isolierte Antibiotikum Corramycin. Die lineare Peptidstruktur enthält eine…”
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