Search Results - "Pêgo, Ana P."

Laminin-Inspired Cell-Instructive Microenvironments for Neural Stem Cells by Barros, Daniela, Amaral, Isabel F, Pêgo, Ana P

“…Laminin is a heterotrimeric glycoprotein with a key role in the formation and maintenance of the basement membrane architecture and properties, as well as on…”
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Engineering a Novel Self-Assembled Multi-siRNA Nanocaged Architecture with Controlled Enzyme-Mediated siRNA Release by Moreno, Pedro M. D., Cortinhas, João, Martins, Ana S., Pêgo, Ana P.

“…The RNA interference (RNAi) chemical and structural design space has evolved since its original definitions. Although this has led to the development of RNAi…”
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PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal brain ischemia by Santos, Sofia D., Xavier, Miguel, Leite, Diana M., Moreira, Débora A., Custódio, Beatriz, Torrado, Marília, Castro, Rita, Leiro, Victoria, Rodrigues, João, Tomás, Helena, Pêgo, Ana P.

“…Drug delivery to the central nervous system is restricted by the blood-brain barrier (BBB). However, with the onset of stroke, the BBB becomes leaky, providing…”
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BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury by Lopes, Cátia D.F, Gonçalves, Nádia P, Gomes, Carla P, Saraiva, Maria J, Pêgo, Ana P

“…Abstract Neuron-targeted gene delivery is a promising strategy to treat peripheral neuropathies. Here we propose the use of polymeric nanoparticles based on…”
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Non-viral gene delivery to mesenchymal stem cells: methods, strategies and application in bone tissue engineering and regeneration by Santos, José L, Pandita, Deepti, Rodrigues, João, Pêgo, Ana P, Granja, Pedro L, Tomás, Helena

“…Mesenchymal stem cells (MSCs) can be isolated from several tissues in the body, have the ability to self-renewal, show immune suppressive properties and are…”
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Functionalization of poly(amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells by Santos, José L., Oliveira, Hugo, Pandita, Deepti, Rodrigues, João, Pêgo, Ana P., Granja, Pedro L., Tomás, Helena

“…A new family of gene delivery vectors is synthesized consisting of a medium-size generation PAMAM dendrimer (generation 5, with amine termini) core randomly…”
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Chitosan/siRNA Nanoparticles Biofunctionalize Nerve Implants and Enable Neurite Outgrowth by Mittnacht, Ursula, Hartmann, Hanna, Hein, San, Oliveira, Hugo, Dong, Mingdong, P. Pêgo, Ana, Kjems, Jørgen, Howard, Kenneth A., Schlosshauer, Burkhard

“…Microstructured 20 μm thick polymer filaments used as nerve implants were loaded with chitosan/siRNA nanoparticles to promote nerve regeneration and ensure…”
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The interplay between chemical conjugation and biologic performance in the development of alginate-based 3D matrices to mimic neural microenvironments by Carvalho, Eva D., Morais, Miguel R.G., Pêgo, Ana P., Barrias, Cristina C., Araújo, Marco

“…Biofunctionalization of polysaccharides is a widely used strategy for obtaining extracellular matrix (ECM)-mimicking biomaterials. Still, commonly employed…”
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Gene Delivery into Mesenchymal Stem Cells: A Biomimetic Approach Using RGD Nanoclusters Based on Poly(amidoamine) Dendrimers by Pandita, Deepti, Santos, José L, Rodrigues, João, Pêgo, Ana P, Granja, Pedro L, Tomás, Helena

“…Poly(amidoamine) dendrimers (generations 5 and 6) with amine termini were conjugated with peptides containing the arginine-glycine-aspartic acid (RGD) sequence…”
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Electrochemical miRNA-34a-based biosensor for the diagnosis of Alzheimer’s disease by Pereira, Raquel L., Oliveira, Daniela, Pêgo, Ana P., Santos, Sofia D., Moreira, Felismina T.C.

“…•Good target affinity, with a broad linearity range and a low LOD.•High selectivity for miRNA-34a, even in serum.•Applicability corroborated by in vitro proof…”
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Dendrimers and Derivatives as Multifunctional Nanotherapeutics for Alzheimer's Disease by Moreira, Débora A, Santos, Sofia D, Leiro, Victoria, Pêgo, Ana P

“…Alzheimer's disease (AD) is the most prevalent form of dementia. It affects more than 30 million people worldwide and costs over US$ 1.3 trillion annually. AD…”
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Enhancing Neuronal Cell Uptake of Therapeutic Nucleic Acids with Tetrahedral DNA Nanostructures by Martins, Ana S. G., Reis, Sara D., Benson, Erik, Domingues, Marco M., Cortinhas, João, Vidal Silva, Joana A., Santos, Sofia D., Santos, Nuno C., Pêgo, Ana P., Moreno, Pedro M. D.

“…The successful translation of therapeutic nucleic acids (NAs) for the treatment of neurological disorders depends on their safe and efficient delivery to…”
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A paradigm shift: Bioengineering meets mechanobiology towards overcoming remyelination failure by Carvalho, Eva D., Morais, Miguel R.G., Ferreira, Helena P., Silva, Mariana M.C., Guimarães, Sofia C., Pêgo, Ana P.

“…Therapeutic strategies aimed at overcoming the loss of myelin sheath in central nervous system demyelinating diseases are often unsuccessful due to nescience…”
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Biological Response Following the Systemic Injection of PEG-PAMAM-Rhodamine Conjugates in Zebrafish by Custódio, Beatriz, Carneiro, Patrícia, Marques, Joana, Leiro, Victoria, Valentim, Ana M, Sousa, Mafalda, Santos, Sofia D, Bessa, José, Pêgo, Ana P

“…Numerous therapeutic and diagnostic approaches used within a clinical setting depend on the administration of compounds via systemic delivery. Biomaterials at…”
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Receptor-Mediated Gene Delivery Using PAMAM Dendrimers Conjugated with Peptides Recognized by Mesenchymal Stem Cells by Santos, José L, Pandita, Deepti, Rodrigues, João, Pêgo, Ana P, Granja, Pedro L, Balian, Gary, Tomás, Helena

“…As mesenchymal stem cells (MSCs) can differentiate into multiple cell types, the delivery of exogenous genes to this type of cell can be an important tool in…”
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Breaking Barriers: Bioinspired Strategies for Targeted Neuronal Delivery to the Central Nervous System by Spencer, Ana P, Torrado, Marília, Custódio, Beatriz, Silva-Reis, Sara C, Santos, Sofia D, Leiro, Victoria, Pêgo, Ana P

“…Central nervous system (CNS) disorders encompass a vast spectrum of pathological conditions and represent a growing concern worldwide. Despite the high social…”
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Engineering hydrogels with affinity-bound laminin as 3D neural stem cell culture systems by Barros, Daniela, Conde-Sousa, Eduardo, Gonçalves, Andreia M, Han, Woojin M, García, Andrés J, Amaral, Isabel F, Pêgo, Ana P

“…Laminin incorporation into biological or synthetic hydrogels has been explored to recapitulate the dynamic nature and biological complexity of neural stem cell…”
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Three‐dimensional culture of single embryonic stem‐derived neural/stem progenitor cells in fibrin hydrogels: neuronal network formation and matrix remodelling by Bento, Ana R., Quelhas, Pedro, Oliveira, Maria J., Pêgo, Ana P., Amaral, Isabel F.

“…In an attempt to improve the efficacy of neural stem/progenitor cell (NSPC) based therapies, fibrin hydrogels are being explored to provide a favourable…”
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Therapeutic antisense oligonucleotides against cancer: hurdling to the clinic by Moreno, Pedro M D, Pêgo, Ana P

“…Under clinical development since the early 90's and with two successfully approved drugs (Fomivirsen and Mipomersen), oligonucleotide-based therapeutics has…”
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Delivery of Splice Switching Oligonucleotides by Amphiphilic Chitosan-Based Nanoparticles by Moreno, Pedro M. D, Santos, Joyce C, Gomes, Carla P, Varela-Moreira, Aida, Costa, Artur, Leiro, Victoria, Mansur, Herman, Pêgo, Ana P

“…Splice switching oligonucleotides (SSOs) are a class of single-stranded antisense oligonucleotides (ssONs) being used as gene therapeutics and demonstrating…”
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