Search Results - "Pérez de la Cruz, V"
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On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress
Published in Neurotoxicology and teratology (01-09-2011)“…Abstract Kynurenic acid (KYNA) is an endogenous metabolite of the kynurenine pathway for tryptophan degradation and an antagonist of both N-methyl- d…”
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Mitochondrial dysfunction related to cell damage induced by 3-hydroxykynurenine and 3-hydroxyanthranilic acid: Non-dependent-effect of early reactive oxygen species production
Published in Neurotoxicology (Park Forest South) (01-09-2015)“…•3-Hydroxykynurenine (3-HK) and 3-hydroxyanthranilic acid (3-HANA) scavenge OH and ONOO−.•3-HK and 3-HANA decrease mitochondrial membrane potential both in…”
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Integrative hypothesis for Huntington's disease: a brief review of experimental evidence
Published in Physiological research (01-01-2007)“…Huntington's disease (HD) is a demential, neurodegenerative inheritable disease affecting middle-aged patients. HD is characterized by uncontrolled choreiform…”
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Kynurenine pathway metabolites and enzymes involved in redox reactions
Published in Neuropharmacology (01-01-2017)“…Oxido-reduction reactions are a fundamental part of the life due to support many vital biological processes as cellular respiration and glucose oxidation. In…”
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N-Acetylcysteine Inhibits Kynurenine Aminotransferase II
Published in Neuroscience (15-09-2020)“…•N-acetylcysteine (NAC) inhibits kynurenine aminotransferase II (KAT II) in vitro.•NAC is a competitive inhibitor of recombinant human KAT II (Ki:…”
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Relevance of Alternative Routes of Kynurenic Acid Production in the Brain
Published in Oxidative medicine and cellular longevity (01-01-2018)“…The catabolism of tryptophan has gained great importance in recent years due to the fact that the metabolites produced during this process, with neuroactive…”
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Low Serum Tryptophan Levels as an Indicator of Global Cognitive Performance in Nondemented Women over 50 Years of Age
Published in Oxidative medicine and cellular longevity (01-01-2018)“…Aging is a physiological decline process. The number of older adults is growing around the world; therefore, the incidence of cognitive impairment, dementia,…”
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Excitotoxic brain damage involves early peroxynitrite formation in a model of Huntington’s disease in rats: Protective role of iron porphyrinate 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III)
Published in Neuroscience (2005)“…Oxidative/nitrosative stress is involved in NMDA receptor-mediated excitotoxic brain damage produced by the glutamate analog quinolinic acid. The purpose of…”
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Quinacrine as a potential treatment for COVID-19 virus infection
Published in European review for medical and pharmacological sciences (01-01-2021)“…A novel coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a current outbreak of infection termed Coronavirus Disease 2019…”
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Cytotoxicity induced by carbon nanotubes in experimental malignant glioma
Published in International journal of nanomedicine (01-01-2017)“…Despite multiple advances in the diagnosis of brain tumors, there is no effective treatment for glioblastoma. Multiwalled carbon nanotubes (MWCNTs), which were…”
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Targeting oxidative/nitrergic stress ameliorates motor impairment, and attenuates synaptic mitochondrial dysfunction and lipid peroxidation in two models of Huntington's disease
Published in Behavioural brain research (16-05-2009)“…In this study, we reproduced two toxic models resembling some motor/kinetic deficits of Huntington's disease induced by bilateral intrastriatal injections of…”
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Iron porphyrinate Fe(TPPS) reduces brain cell damage in rats intrastriatally lesioned by quinolinate
Published in Neurotoxicology and teratology (01-11-2008)“…Abstract It has been recently demonstrated that the reactive nitrogen species (RNS) peroxynitrite (ONOO− ) is involved in the neurotoxic pattern produced by…”
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