Search Results - "Pérez Salvia, Montserrat"

Bromodomain inhibitors and cancer therapy: From structures to applications by Pérez-Salvia, Montserrat, Esteller, Manel

“…Aberrations in the epigenetic landscape are a hallmark of cancer. Alterations in enzymes that are "writers," "erasers," or "readers" of histone modification…”
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In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma by Pérez-Salvia, Montserrat, Aldaba, Eneko, Vara, Yosu, Fabre, Myriam, Ferrer, Cristina, Masdeu, Carme, Zubia, Aizpea, Sebastian, Eider San, Otaegui, Dorleta, Llinàs-Arias, Pere, Rosselló-Tortella, Margalida, Berdasco, Maria, Moutinho, Catia, Setien, Fernando, Villanueva, Alberto, González-Barca, Eva, Muncunill, Josep, Navarro, José-Tomás, Piris, Miguel A, Cossio, Fernando P, Esteller, Manel

“…Cancer origin and development is associated not only with genetic alterations, but also with the disturbance of epigenetic profiles.1 In this regard, the…”
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Bromodomain inhibition shows antitumoral activity in mice and human luminal breast cancer by Pérez-Salvia, Montserrat, Simó-Riudalbas, Laia, Llinàs-Arias, Pere, Roa, Laura, Setien, Fernando, Soler, Marta, de Moura, Manuel Castro, Bradner, James E, Gonzalez-Suarez, Eva, Moutinho, Catia, Esteller, Manel

“…BET bromodomain inhibitors, which have an antitumoral effect against various solid cancer tumor types, have not been studied in detail in luminal breast…”
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Germline variation in O6-methylguanine-DNA methyltransferase (MGMT) as cause of hereditary colorectal cancer by Belhadj, Sami, Moutinho, Cátia, Mur, Pilar, Setien, Fernando, Llinàs-Arias, Pere, Pérez-Salvia, Montserrat, Pons, Tirso, Pineda, Marta, Brunet, Joan, Navarro, Matilde, Capellá, Gabriel, Esteller, Manel, Valle, Laura

“…Somatic epigenetic inactivation of the DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) is frequent in colorectal cancer (CRC); however, its…”
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Circular RNA CpG island hypermethylation-associated silencing in human cancer by Ferreira, Humberto J, Davalos, Veronica, de Moura, Manuel Castro, Soler, Marta, Perez-Salvia, Montserrat, Bueno-Costa, Alberto, Setien, Fernando, Moran, Sebastian, Villanueva, Alberto, Esteller, Manel

“…Noncoding RNAs (ncRNAs), such as microRNAs and long noncoding RNAs (lncRNAs), participate in cellular transformation. Work done in the last decade has also…”
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KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer by Simó-Riudalbas, Laia, Pérez-Salvia, Montserrat, Setien, Fernando, Villanueva, Alberto, Moutinho, Catia, Martínez-Cardús, Anna, Moran, Sebastian, Berdasco, Maria, Gomez, Antonio, Vidal, Enrique, Soler, Marta, Heyn, Holger, Vaquero, Alejandro, de la Torre, Carolina, Barceló-Batllori, Silvia, Vidal, August, Roz, Luca, Pastorino, Ugo, Szakszon, Katalin, Borck, Guntram, Moura, Conceição S, Carneiro, Fátima, Zondervan, Ilse, Savola, Suvi, Iwakawa, Reika, Kohno, Takashi, Yokota, Jun, Esteller, Manel

“…Recent efforts to sequence human cancer genomes have highlighted that point mutations in genes involved in the epigenetic setting occur in tumor cells. Small…”
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Barcelona conference on epigenetics and cancer: 50 years of histone acetylation by Perez-Salvia, Montserrat, Simó-Riudalbas, Laia, Ausió, Juan, Esteller, Manel

“…The Barcelona Conference on Epigenetics and Cancer (BCEC) was held in Barcelona, Spain, on October 1 st and 2 nd , 2014. The meeting was co-organized by the…”
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Epigenetic loss of the endoplasmic reticulum-associated degradation inhibitor SVIP induces cancer cell metabolic reprogramming by Llinàs-Arias, Pere, Rosselló-Tortella, Margalida, López-Serra, Paula, Pérez-Salvia, Montserrat, Setién, Fernando, Marin, Silvia, Muñoz, Juan P, Junza, Alexandra, Capellades, Jordi, Calleja-Cervantes, María E, Ferreira, Humberto J, de Moura, Manuel Castro, Srbic, Marina, Martínez-Cardús, Anna, de la Torre, Carolina, Villanueva, Alberto, Cascante, Marta, Yanes, Oscar, Zorzano, Antonio, Moutinho, Catia, Esteller, Manel

“…The endoplasmic reticulum (ER) of cancer cells needs to adapt to the enhanced proteotoxic stress associated with the accumulation of unfolded, misfolded and…”
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Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program by Janin, Maxime, Ortiz-Barahona, Vanessa, de Moura, Manuel Castro, Martínez-Cardús, Anna, Llinàs-Arias, Pere, Soler, Marta, Nachmani, Daphna, Pelletier, Joffrey, Schumann, Ulrike, Calleja-Cervantes, Maria E., Moran, Sebastian, Guil, Sonia, Bueno-Costa, Alberto, Piñeyro, David, Perez-Salvia, Montserrat, Rosselló-Tortella, Margalida, Piqué, Laia, Bech-Serra, Joan J., De La Torre, Carolina, Vidal, August, Martínez-Iniesta, María, Martín-Tejera, Juan F., Villanueva, Alberto, Arias, Alexandra, Cuartas, Isabel, Aransay, Ana M., La Madrid, Andres Morales, Carcaboso, Angel M., Santa-Maria, Vicente, Mora, Jaume, Fernandez, Agustin F., Fraga, Mario F., Aldecoa, Iban, Pedrosa, Leire, Graus, Francesc, Vidal, Noemi, Martínez-Soler, Fina, Tortosa, Avelina, Carrato, Cristina, Balañá, Carme, Boudreau, Matthew W., Hergenrother, Paul J., Kötter, Peter, Entian, Karl-Dieter, Hench, Jürgen, Frank, Stephan, Mansouri, Sheila, Zadeh, Gelareh, Dans, Pablo D., Orozco, Modesto, Thomas, George, Blanco, Sandra, Seoane, Joan, Preiss, Thomas, Pandolfi, Pier Paolo, Esteller, Manel

“…Tumors have aberrant proteomes that often do not match their corresponding transcriptome profiles. One possible cause of this discrepancy is the existence of…”
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Abstract 4784: Effect of epigenetic drugs on chromatin remodeling complexes disrupted in cancer by Pérez-Salvia, Montserrat, Simó-Riudalbas, Laia, Esteller, Manel

“…Chromatin remodeling complexes undergo dynamic assembly of chromatin to facilitate the access to DNA packed in nucleosomes during DNA-template cellular…”
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Germline variation in O 6 -methylguanine-DNA methyltransferase (MGMT) as cause of hereditary colorectal cancer by Belhadj, Sami, Moutinho, Cátia, Mur, Pilar, Setien, Fernando, Llinàs-Arias, Pere, Pérez-Salvia, Montserrat, Pons, Tirso, Pineda, Marta, Brunet, Joan, Navarro, Matilde, Capellá, Gabriel, Esteller, Manel, Valle, Laura

“…Somatic epigenetic inactivation of the DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) is frequent in colorectal cancer (CRC); however, its…”
Get full text

Barcelona conference on epigenetics and cancer: 50 years of histone acetylation by Pérez Salvia, Montserrat, Simó Riudalbas, Laia, Ausió, Juan, Esteller, Manel

“…The Barcelona Conference on Epigenetics and Cancer (BCEC) was held in Barcelona, Spain, on October 1 and 2 , 2014. The meeting was co-organized by the Cancer…”
Get full text

In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma by Pérez Salvia, Montserrat, Aldaba, Eneko, Vara, Yosu, Fabre, Myriam, Ferrer, Cristina, Masdeu, Carme, Zubia, Aizpea, San Sebastian, Eider, Otaegui, Dorleta, Llinàs-Arias, Pere, Rosselló-Tortella, Margalida, Berdasco, María, Moutinho, Cátia, Setién, Fernando, Villanueva Garatachea, Alberto, González Barca, Eva, Muncunill, Josep, Navarro, José-Tomás, Piris, Miguel A, Cossio, Fernando P, Esteller, Manel

“…Cancer origin and development is associated not only with genetic alterations, but also with the disturbance of epigenetic profiles.1 In this regard, the…”
Get full text

Epigenetic loss of RNA‑methyltransferase NSUN5 in glioma targets ribosomes to drive stress adaptive translational program by Janin, Maxime, Ortiz‑Barahona, Vanessa, Esteller, Manel, Castro de Moura, Manuel, Carrato, Cristina, Martínez Cardús, Anna, Llinàs-Arias, Pere, Soler Gallart, Marta, Nachmani, Daphna, Pelletier, Joffrey, Schumann, Ulrike, Calleja Cervantes, Maria E, Moran, Sebastian, Guil, Sonia, Bueno Costa, Alberto, Piñeyro, David, Pérez Salvia, Montserrat, Rosselló-Tortella, Margalida, Piqué, Laia, Bech-Serra, Joan J, Torre Gómez, Carolina de la, Vidal-Bel, August, Martínez Iniesta, María, Martín‑Tejera, Juan F, Tejera, Juan F, Villanueva Garatachea, Alberto, Arias, Alexandra, Cuartas, Isabel, Aransay, Ana Maria, Morales La Madrid, Andres, Carcaboso, Angel M, Santa-Maria Lopez, Vicente, Mora Graupera, Jaume, Fernández, Agustín F, Fraga, Mario F, Aldecoa Ansórregui, Iban, Pedrosa, Leire, Graus Ribas, Francesc, Martínez Soler, Fina, Tortosa i Moreno, Avelina

“…Tumors have aberrant proteomes that often do not match their corresponding transcriptome profiles. One possible cause of this discrepancy is the existence of…”
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Epigenetic loss of RNA‑methyltransferase NSUN5 in glioma targets ribosomes to drive stress adaptive translational program by Janin, Maxime, Ortiz‑Barahona, Vanessa, Esteller, Manel, Castro de Moura, Manuel, Carrato, Cristina, Martínez Cardús, Anna, Llinàs-Arias, Pere, Soler Gallart, Marta, Nachmani, Daphna, Pelletier, Joffrey, Schumann, Ulrike, Calleja Cervantes, Maria E, Moran, Sebastian, Guil, Sonia, Bueno Costa, Alberto, Piñeyro, David, Pérez Salvia, Montserrat, Rosselló-Tortella, Margalida, Piqué, Laia, Bech-Serra, Joan J, Torre Gómez, Carolina de la, Vidal-Bel, August, Martínez Iniesta, María, Martín‑Tejera, Juan F, Tejera, Juan F, Villanueva Garatachea, Alberto, Arias, Alexandra, Cuartas, Isabel, Aransay, Ana Maria, Morales La Madrid, Andres, Carcaboso, Angel M, Santa-Maria Lopez, Vicente, Mora Graupera, Jaume, Fernández, Agustín F, Fraga, Mario F, Aldecoa Ansórregui, Iban, Pedrosa, Leire, Graus Ribas, Francesc, Martínez Soler, Fina, Tortosa i Moreno, Avelina

“…Tumors have aberrant proteomes that often do not match their corresponding transcriptome profiles. One possible cause of this discrepancy is the existence of…”
Get full text

Epigenetic loss of RNA‑methyltransferase NSUN5 in glioma targets ribosomes to drive stress adaptive translational program by Janin, Maxime, Ortiz‑Barahona, Vanessa, Esteller, Manel, Castro de Moura, Manuel, Carrato, Cristina, Martínez Cardús, Anna, Llinàs-Arias, Pere, Soler Gallart, Marta, Nachmani, Daphna, Pelletier, Joffrey, Schumann, Ulrike, Calleja Cervantes, Maria E, Moran, Sebastian, Guil, Sonia, Bueno Costa, Alberto, Piñeyro, David, Pérez Salvia, Montserrat, Rosselló-Tortella, Margalida, Piqué, Laia, Bech-Serra, Joan J, Torre Gómez, Carolina de la, Vidal-Bel, August, Martínez Iniesta, María, Martín‑Tejera, Juan F, Tejera, Juan F, Villanueva Garatachea, Alberto, Arias, Alexandra, Cuartas, Isabel, Aransay, Ana Maria, Morales La Madrid, Andres, Carcaboso, Angel M, Santa-Maria Lopez, Vicente, Mora Graupera, Jaume, Fernández, Agustín F, Fraga, Mario F, Aldecoa Ansórregui, Iban, Pedrosa, Leire, Graus Ribas, Francesc, Martínez Soler, Fina, Tortosa i Moreno, Avelina

“…Tumors have aberrant proteomes that often do not match their corresponding transcriptome profiles. One possible cause of this discrepancy is the existence of…”
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Bromodomain inhibition shows antitumoral activity in mice and human luminal breast cancer by Pérez Salvia, Montserrat, Simó-Riudalbas, Laia, Llinàs-Arias, Pere, Roa, Laura, Setién, Fernando, Soler, Marta, Castro de Moura, Manuel, Bradner, James E, González Suárez, Eva, Moutinho, Cátia, Esteller, Manel

“…BET bromodomain inhibitors, which have an antitumoral effect against various solid cancer tumor types, have not been studied in detail in luminal breast…”
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Abstract 4725: Efficacy of a new small-molecule inhibitor of histone deacetylase 6 (HDAC6) in preclinical models of B-cell lymphoma and acute myeloid leukemia by Villanueva, Lorea, Perez-Salvia, Montserrat, Aldaba, Eneko, Vara, Yosu, Fabre, Myriam, Ferrer, Cristina, Masdeu, Carme, Zubia, Aizpea, Sebastian, Eider San, Otaegui, Dorleta, Llinàs-Arias, Pere, Rosselló-Tortella, Margalida, Berdasco, María, Setien, Fernando, Moutinho, Catia, Villanueva, Alberto, González-Barca, Eva, Muncunill, Josep, Navarro, José Tomás, Piris, Miguel Ángel, Cossio, Fernando, Esteller, Manel

“…Histone deacetylase 6 (HDAC6) is a protein modifier that is an increasingly attractive pharmacological target. Interestingly, the observation that the HDAC6…”
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Efficacy of a New Small-Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) in Preclinical Models of B-Cell Lymphoma and Acute Myeloid Leukemia by Perez-Salvia, Montserrat, Eneko, Aldaba, Yosu, Vara, Myriam, Fabre, Cristina, Ferrer, Carme, Masdeu, Aizpea, Zubia, Eider, San Sebastian, Dorleta, Otaegui, Pere, Llinàs-Arias, Margalida, Rosselló-Tortella, Maria, Berdasco, Fernando, Setien, Catia, Moutinho, Alberto, Villanueva, González-Barca, Eva, Muncunill, Josep, Navarro, Jose Tomas, Piris, Miguel Angel, Fernando, Cossio, Esteller, Manel

“…Histone deacetylase 6 (HDAC6) is a protein modifier that is an increasingly attractive pharmacological target. Interestingly, the observation that the HDAC6…”
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