Search Results - "Pérez Pineiro, Rolando"

SERS assisted ultra-fast peptidic screening: a new tool for drug discovery by Pérez-Pineiro, Rolando, Correa-Duarte, Miguel A, Salgueirino, Veronica, Alvarez-Puebla, Ramon A

“…Herein we present a direct label-free ultra-fast method for the identification and classification of the active members of a combinatorial library directly on…”
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Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensis by Monzote Fidalgo, Lianet, Montalvo Alvarez, Ana Margarita, Geigel, Lisset Fonseca, Pérez Pineiro, Rolando, Suárez Navarro, Margarita, Rodríguez Cabrera, Hortensia

“…Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania…”
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The prion protein binds thiamine by Perez‐Pineiro, Rolando, Bjorndahl, Trent C., Berjanskii, Mark V., Hau, David, Li, Li, Huang, Alan, Lee, Rose, Gibbs, Ebrima, Ladner, Carol, Dong, Ying Wei, Abera, Ashenafi, Cashman, Neil R., Wishart, David S.

“…Although highly conserved throughout evolution, the exact biological function of the prion protein is still unclear. In an effort to identify the potential…”
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Development of a Raman-Based Test for Rapid Thiol Scavenger Detection in Oil and Gas Applications by Perez Pineiro, Rolando, Hoshowski, Jody, Alhammoud, Adnan, Jenkins, Alyn

“…A rapid and efficient Raman-based method to identify potential thiol scavengers for oil and gas applications is described. The procedure was validated using…”
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HMDB 3.0--The Human Metabolome Database in 2013 by Wishart, David S, Jewison, Timothy, Guo, An Chi, Wilson, Michael, Knox, Craig, Liu, Yifeng, Djoumbou, Yannick, Mandal, Rupasri, Aziat, Farid, Dong, Edison, Bouatra, Souhaila, Sinelnikov, Igor, Arndt, David, Xia, Jianguo, Liu, Philip, Yallou, Faizath, Bjorndahl, Trent, Perez-Pineiro, Rolando, Eisner, Roman, Allen, Felicity, Neveu, Vanessa, Greiner, Russ, Scalbert, Augustin

“…The Human Metabolome Database (HMDB) (www.hmdb.ca) is a resource dedicated to providing scientists with the most current and comprehensive coverage of the…”
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Raman and DFT Study of the H2S Scavenger Reaction of HET-TRZ under Simulated Contactor Tower Conditions by Perez Pineiro, Rolando, Peeples, Craig A, Hendry, Jonathan, Hoshowski, Jody, Hanna, Gabriel, Jenkins, Alyn

“…Raman spectroscopy is a rapid and noninvasive analytical technique used for the analysis of complex materials in complex matrices. Herein, we report for the…”
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Virtual screening and biological evaluation of inhibitors targeting the XPA-ERCC1 interaction by Barakat, Khaled H, Jordheim, Lars P, Perez-Pineiro, Rolando, Wishart, David, Dumontet, Charles, Tuszynski, Jack A

“…Nucleotide excision repair (NER) removes many types of DNA lesions including those induced by UV radiation and platinum-based therapy. Resistance to…”
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Discovery of Small Molecule Inhibitors that Interact with γ-Tubulin by Friesen, Douglas E., Barakat, Khaled H., Semenchenko, Valentyna, Perez-Pineiro, Rolando, Fenske, Bruce W., Mane, Jonathan, Wishart, David S., Tuszynski, Jack A.

“…Recent studies have shown an overexpression of γ‐tubulin in human glioblastomas and glioblastoma cell lines. As the 2‐year survival rate for glioblastoma is…”
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Experimental and Computational Study of the Interaction of Novel Colchicinoids with a Recombinant Human αI/βI-Tubulin Heterodimer by Mane, Jonathan Y., Semenchenko, Valentyna, Perez-Pineiro, Rolando, Winter, Philip, Wishart, David, Tuszynski, Jack A.

“…The binding free energies on human tubulin of selected colchicine and thiocolchicine compounds were determined. Two methods were used for the determination of…”
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A Simple and Convenient Synthesis of Unlabeled and 13C-Labeled 3-(3-Hydroxyphenyl)-3-Hydroxypropionic Acid and Its Quantification in Human Urine Samples by Khaniani, Yeganeh, Lipfert, Matthias, Bhattacharyya, Dipanjan, Perez Pineiro, Rolando, Zheng, Jiamin, Wishart, David

“…An improved method to synthesize the highly abundant and biomedically important urinary metabolite 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA) is…”
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Synthesis of sulfur-containing aryl and heteroaryl vinyls via Suzuki–Miyaura cross-coupling for the preparation of SERS-active polymers by Perez-Pineiro, Rolando, Dai, Sheng, Alvarez-Puebla, Ramon, Wigginton, James, Al-Hourani, Baker Jawabrah, Fenniri, Hicham

“…Mercaptomethyl (hetero)aryl vinyls via Suzuki cross-coupling The preparation of sulfur-containing aryl and heteroaryl vinyl co-monomers via Suzuki–Miyaura…”
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Synthesis and Antiprotozoal Evaluation of New N 4 ‐(Benzyl)spermidyl‐linked bis(1,3,5‐thiadiazinane‐2‐thiones) by Coro, Julieta, Little, Susan, Yardley, Vanessa, Suárez, Margarita, Rodríguez, Hortensia, Martín, Nazario, Perez‐Pineiro, Rolando

“…The synthesis and in‐vitro antiprotozoal evaluation of novel N 4 ‐(benzyl)spermidyl‐linked bis(1,3,5‐thiadiazinane‐2‐thione) (bis‐THTT) derivatives from N 4…”
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Synthesis and Antiprotozoal Evaluation of New N4-(Benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones) by Coro, Julieta, Little, Susan, Yardley, Vanessa, Suárez, Margarita, Rodríguez, Hortensia, Martín, Nazario, Perez-Pineiro, Rolando

“…The synthesis and in‐vitro antiprotozoal evaluation of novel N4‐(benzyl)spermidyl‐linked bis(1,3,5‐thiadiazinane‐2‐thione) (bis‐THTT) derivatives from…”
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Raman and DFT Study of the H 2 S Scavenger Reaction of HET-TRZ under Simulated Contactor Tower Conditions by Perez Pineiro, Rolando, Peeples, Craig A., Hendry, Jonathan, Hoshowski, Jody, Hanna, Gabriel, Jenkins, Alyn

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Small molecule inhibitors of ERCC1-XPF protein-protein interaction synergize alkylating agents in cancer cells by Jordheim, Lars Petter, Barakat, Khaled H, Heinrich-Balard, Laurence, Matera, Eva-Laure, Cros-Perrial, Emeline, Bouledrak, Karima, El Sabeh, Rana, Perez-Pineiro, Rolando, Wishart, David S, Cohen, Richard, Tuszynski, Jack, Dumontet, Charles

“…The benefit of cancer chemotherapy based on alkylating agents is limited because of the action of DNA repair enzymes, which mitigate the damage induced by…”
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Detailed Biophysical Characterization of the Acid-Induced PrPc to PrPβ Conversion Process by Bjorndahl, Trent C, Zhou, Guo-Ping, Liu, Xuehui, Perez-Pineiro, Rolando, Semenchenko, Valentyna, Saleem, Fozia, Acharya, Sandipta, Bujold, Adina, Sobsey, Constance A, Wishart, David S

“…Prions are believed to spontaneously convert from a native, monomeric highly helical form (called PrPc) to a largely β-sheet-rich, multimeric and insoluble…”
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Detailed biophysical characterization of the acid-induced PrP(c) to PrP(β) conversion process by Bjorndahl, Trent C, Zhou, Guo-Ping, Liu, Xuehui, Perez-Pineiro, Rolando, Semenchenko, Valentyna, Saleem, Fozia, Acharya, Sandipta, Bujold, Adina, Sobsey, Constance A, Wishart, David S

“…Prions are believed to spontaneously convert from a native, monomeric highly helical form (called PrP(c)) to a largely β-sheet-rich, multimeric and insoluble…”
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In silico studies and fluorescence binding assays of potential anti-prion compounds reveal an important binding site for prion inhibition from PrPC to PrPSc by Pagadala, Nataraj S., Perez-Pineiro, Rolando, Wishart, David S., Tuszynski, Jack A.

“…To understand the pharmacophore properties of 2-aminothiazoles and design novel inhibitors against the prion protein, a highly predictive 3D quantitative…”
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A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds by Ladner-Keay, Carol L., Ross, Li, Perez-Pineiro, Rolando, Zhang, Lun, Bjorndahl, Trent C., Cashman, Neil, Wishart, David S.

“…Prion diseases are caused by the conversion of normal cellular prion proteins (PrP) into lethal prion aggregates. These prion aggregates are composed of…”
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In silico studies and fluorescence binding assays of potential anti-prion compounds reveal an important binding site for prion inhibition from PrP(C) to PrP(Sc) by Pagadala, Nataraj S, Perez-Pineiro, Rolando, Wishart, David S, Tuszynski, Jack A

“…To understand the pharmacophore properties of 2-aminothiazoles and design novel inhibitors against the prion protein, a highly predictive 3D quantitative…”
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