Search Results - "Pérez‐Yagüe, Sonia"

Polyethylenimine-coated SPIONs trigger macrophage activation through TLR-4 signaling and ROS production and modulate podosome dynamics by Mulens-Arias, Vladimir, Rojas, José M, Pérez-Yagüe, Sonia, Morales, María P, Barber, Domingo F

“…Abstract Polyethylenimine (PEI) is widely used as transfection agent in preclinical studies, both in vitro and in vivo. Due to their unique chemical and…”
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An electrostatically conjugated-functional MNK1 aptamer reverts the intrinsic antitumor effect of polyethyleneimine-coated iron oxide nanoparticles in vivo in a human triple-negative cancer xenograft by Mulens-Arias, Vladimir, Portilla, Yadileiny, Pérez-Yagüe, Sonia, Ferreras-Martín, Raquel, Martín, M. Elena, González, Victor M., Barber, Domingo F.

“…Background Triple-negative breast cancer (TNBC) remains a difficult breast cancer subtype to treat as it exhibits a particularly aggressive behavior. The…”
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PI3K p110γ deletion attenuates murine atherosclerosis by reducing macrophage proliferation but not polarization or apoptosis in lesions by Zotes, Teresa M, Arias, Cristina F, Fuster, José J, Spada, Roberto, Pérez-Yagüe, Sonia, Hirsch, Emilio, Wymann, Matthias, Carrera, Ana C, Andrés, Vicente, Barber, Domingo F

“…Atherosclerosis is an inflammatory disease regulated by infiltrating monocytes and T cells, among other cell types. Macrophage recruitment to atherosclerotic…”
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PI3K p110δ is expressed by gp38(-)CD31(+) and gp38(+)CD31(+) spleen stromal cells and regulates their CCL19, CCL21, and LTβR mRNA levels by Zotes, Teresa M, Spada, Roberto, Mulens, Vladimir, Pérez-Yagüe, Sonia, Sorzano, Carlos O, Okkenhaug, Klaus, Carrera, Ana C, Barber, Domingo F

“…The role of p110δ PI3K in lymphoid cells has been studied extensively, showing its importance in immune cell differentiation, activation and development…”
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Interaction of Iron Oxide Nanoparticles with Macrophages Is Influenced Distinctly by “Self” and “Non-Self” Biological Identities by Portilla, Yadileiny, Mulens-Arias, Vladimir, Daviu, Neus, Paradela, Alberto, Pérez-Yagüe, Sonia, Barber, Domingo F.

“…Upon contact with biological fluids like serum, a protein corona (PC) complex forms on iron oxide nanoparticles (IONPs) in physiological environments and the…”
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Iron Oxide Nanoparticle Coatings Dictate Cell Outcomes Despite the Influence of Protein Coronas by Portilla, Yadileiny, Mellid, Sara, Paradela, Alberto, Ramos-Fernández, Antonio, Daviu, Neus, Sanz-Ortega, Laura, Pérez-Yagüe, Sonia, Morales, María P, Barber, Domingo F

“…A critical issue in nanomedicine is to understand the complex dynamics that dictate the interactions of nanoparticles (NPs) with their biological milieu. The…”
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Magnetic Nanoparticles Attached to the NK Cell Surface for Tumor Targeting in Adoptive Transfer Therapies Does Not Affect Cellular Effector Functions by Sanz-Ortega, Laura, Rojas, José M, Portilla, Yadileiny, Pérez-Yagüe, Sonia, Barber, Domingo F

“…Adoptive cell transfer therapy is currently one of the most promising approaches for cancer treatment. This therapy has some limitations, however, such as the…”
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Different coatings on magnetic nanoparticles dictate their degradation kinetics in vivo for 15 months after intravenous administration in mice by Portilla, Yadileiny, Fernández-Afonso, Yilian, Pérez-Yagüe, Sonia, Mulens-Arias, Vladimir, Morales, M Puerto, Gutiérrez, Lucía, Barber, Domingo F

“…The surface coating of iron oxide magnetic nanoparticle (MNPs) drives their intracellular trafficking and degradation in endolysosomes, as well as dictating…”
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Magnetic targeting of adoptively transferred tumour-specific nanoparticle-loaded CD8 + T cells does not improve their tumour infiltration in a mouse model of cancer but promotes the retention of these cells in tumour-draining lymph nodes by Sanz-Ortega, Laura, Portilla, Yadileiny, Pérez-Yagüe, Sonia, Barber, Domingo F

“…Adoptive T cell-transfer (ATC) therapy is a highly promising cancer-treatment approach. However, in vivo-administered T cells tend to disperse, with only a…”
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PI3K p85 β regulatory subunit deficiency does not affect NK cell differentiation and increases NKG2D‐mediated activation by Rojas, José M., Spada, Roberto, Sanz‐Ortega, Laura, Morillas, Laura, Mejías, Raquel, Mulens‐Arias, Vladimir, Pérez‐Yagüe, Sonia, Barber, Domingo F.

“…Deficiency of the p85β regulatory subunit of PI3K does not affect NK cell differentiation and increases NK cell activity. Activation of NK cells depends on a…”
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Microthrombotic Renal Vascular Lesions Are Associated to Increased Renal Inflammatory Infiltration in Murine Lupus Nephritis by Gonzalo-Gil, Elena, García-Herrero, Carmen, Toldos, Oscar, Usategui, Alicia, Criado, Gabriel, Pérez-Yagüe, Sonia, Barber, Domingo F, Pablos, Jose L, Galindo, Maria

“…Vascular microthrombotic lesions in lupus nephritis with or without antiphospholipid antibodies may relate to worse renal outcomes. Whether microthrombotic…”
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Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications by Mejías, Raquel, Gutiérrez, Lucía, Salas, Gorka, Pérez-Yagüe, Sonia, Zotes, Teresa M., Lázaro, Francisco J., Morales, María P., Barber, Domingo F.

“…Although iron oxide magnetic nanoparticles (MNP) have been proposed for numerous biomedical applications, little is known about their biotransformation and…”
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Dimercaptosuccinic acid-coated magnetite nanoparticles for magnetically guided in vivo delivery of interferon gamma for cancer immunotherapy by Mejías, Raquel, Pérez-Yagüe, Sonia, Gutiérrez, Lucía, Cabrera, Lourdes I, Spada, Roberto, Acedo, Pilar, Serna, Carlos J, Lázaro, Francisco J, Villanueva, Ángeles, Morales, María del Puerto, Barber, Domingo F

“…Abstract As radio- and chemotherapy-based cancer treatments affect both tumors and healthy tissue, cancer immunotherapy attempts to specifically enhance the…”
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Polyethylenimine-coated SPION exhibits potential intrinsic anti-metastatic properties inhibiting migration and invasion of pancreatic tumor cells by Mulens-Arias, Vladimir, Rojas, José Manuel, Pérez-Yagüe, Sonia, Morales, María del Puerto, Barber, Domingo F.

“…Due to its aggressive behavior, pancreatic cancer is one of the principal causes of cancer-related deaths. The highly metastatic potential of pancreatic tumor…”
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NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery by Spada, Roberto, Rojas, Jose´ M., Pe´rez‐Yagu¨e, Sonia, Mulens, Vladimir, Cannata‐Ortiz, Pablo, Bragado, Rafael, Barber, Domingo F.

“…NKG2D ligand expression, NK cells, and cytokine expression by NK cells could play a role in the lupus nephritic process. NK cells are a major component of the…”
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The surface coating of iron oxide nanoparticles drives their intracellular trafficking and degradation in endolysosomes differently depending on the cell type by Portilla, Yadileiny, Mulens-Arias, Vladimir, Paradela, Alberto, Ramos-Fernández, Antonio, Pérez-Yagüe, Sonia, Morales, M. Puerto, Barber, Domingo F.

“…Magnetic nanoparticles (MNPs) are potential theranostic tools that are biodegraded through different endocytic pathways. However, little is known about the…”
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Polyethylenimine-coated superparamagnetic iron oxide nanoparticles impair in vitro and in vivo angiogenesis by Mulens-Arias, Vladimir, Rojas, José Manuel, Sanz-Ortega, Laura, Portilla, Yadileiny, Pérez-Yagüe, Sonia, Barber, Domingo F.

“…Endothelial cells are essential to tumor vascularization and impairing their activity can potentially limit tumor growth. Since polyethylenimine (PEI)-coated…”
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Superparamagnetic iron oxide nanoparticle uptake alters M2 macrophage phenotype, iron metabolism, migration and invasion by Rojas, José M, Sanz-Ortega, Laura, Mulens-Arias, Vladimir, Gutiérrez, Lucía, Pérez-Yagüe, Sonia, Barber, Domingo F

“…Abstract Superparamagnetic iron oxide nanoparticles (SPIONs) have shown promise as contrast agents and nanocarriers for drug delivery. Their impact on…”
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Time-course assessment of the aggregation and metabolization of magnetic nanoparticles by Rojas, José M., Gavilán, Helena, del Dedo, Vanesa, Lorente-Sorolla, Eduardo, Sanz-Ortega, Laura, da Silva, Gustavo B., Costo, Rocío, Perez-Yagüe, Sonia, Talelli, Marina, Marciello, Marzia, Morales, M. Puerto, Barber, Domingo F., Gutiérrez, Lucía

“…[Display omitted] To successfully develop biomedical applications for magnetic nanoparticles, it is imperative that these nanoreagents maintain their magnetic…”
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PI3K p110[gamma] Deletion Attenuates Murine Atherosclerosis by Reducing Macrophage Proliferation but Not Polarization or Apoptosis in Lesions by Zotes, Teresa M, Arias, Cristina F, Fuster, José J, Spada, Roberto, Pérez-Yagüe, Sonia, Hirsch, Emilio, Wymann, Matthias, Carrera, Ana C, Andrés, Vicente, Barber, Domingo F

“…Atherosclerosis is an inflammatory disease regulated by infiltrating monocytes and T cells, among other cell types. Macrophage recruitment to atherosclerotic…”
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