Search Results - "Pérez‐Cerdá, Fernando"

Clonal Glial Response in a Multiple Sclerosis Mouse Model by Bribian, Ana, Pérez-Cerdá, Fernando, Matute, Carlos, López-Mascaraque, Laura

“…Multiple sclerosis (MS) is an autoimmune disease causing central nervous system (CNS) demyelination and axonal injury. In the last years the importance of…”
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Excitotoxic damage to white matter by Matute, Carlos, Alberdi, Elena, Domercq, María, Sánchez‐Gómez, María‐Victoria, Pérez‐Samartín, Alberto, Rodríguez‐Antigüedad, Alfredo, Pérez‐Cerdá, Fernando

“…Glutamate kills neurons by excitotoxicity, which is caused by sustained activation of glutamate receptors. In recent years, it has been shown that glutamate…”
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A Clonal NG2-Glia Cell Response in a Mouse Model of Multiple Sclerosis by Barriola, Sonsoles, Pérez-Cerdá, Fernando, Matute, Carlos, Bribián, Ana, López-Mascaraque, Laura

“…NG2-glia, also known as oligodendrocyte precursor cells (OPCs), have the potential to generate new mature oligodendrocytes and thus, to contribute to tissue…”
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Increased expression and function of glutamate transporters in multiple sclerosis by Vallejo-Illarramendi, Ainara, Domercq, María, Pérez-Cerdá, Fernando, Ravid, Rivka, Matute, Carlos

“…Recent studies have shown that glutamate excitotoxicity may be a component in the etiology of multiple sclerosis (MS). Glutamate transporters determine the…”
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Multiple sclerosis: novel perspectives on newly forming lesions by Matute, Carlos, Pérez-Cerdá, Fernando

“…The mechanisms underlying lesion formation in multiple sclerosis are unknown. The prevailing view is that macrophages are primary mediators of myelin…”
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Inhibition of Casein Kinase 2 Protects Oligodendrocytes From Excitotoxicity by Attenuating JNK/p53 Signaling Cascade by Canedo-Antelo, Manuel, Serrano, Mari Paz, Manterola, Andrea, Ruiz, Asier, Llavero, Francisco, Mato, Susana, Zugaza, José Luis, Pérez-Cerdá, Fernando, Matute, Carlos, Sánchez-Gómez, María Victoria

“…Oligodendrocytes are highly vulnerable to glutamate excitotoxicity, a central mechanism involved in tissue damage in Multiple Sclerosis (MS). Sustained…”
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Increased expression of glutamate transporters in subcortical white matter after transient focal cerebral ischemia by Arranz, Amaia M, Gottlieb, Miroslav, Pérez-Cerdá, Fernando, Matute, Carlos

“…Abstract Transient focal cerebral ischemia leads to extensive excitotoxic glial damage in the subcortical white matter. Efficient reuptake of released…”
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Functional glutamate transport in rodent optic nerve axons and glia by Arranz, Amaia M., Hussein, Ali, Alix, James J. P., Pérez-Cerdá, Fernando, Allcock, Natalie, Matute, Carlos, Fern, Robert

“…Recent findings suggest that synaptic‐type glutamate signaling operates between axons and their supporting glial cells. Glutamate reuptake will be a necessary…”
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The link between excitotoxic oligodendroglial death and demyelinating diseases by Matute, Carlos, Alberdi, Elena, Domercq, Marı́a, Pérez-Cerdá, Fernando, Pérez-Samartı́n, Alberto, Sánchez-Gómez, Marı́a Victoria

“…Oligodendrocytes, the myelinating cells of CNS axons, are highly vulnerable to excitotoxic signals mediated by glutamate receptors of the AMPA and kainate…”
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Pío del Río Hortega and the discovery of the oligodendrocytes by Pérez-Cerdá, Fernando, Sánchez-Gómez, María Victoria, Matute, Carlos

“…Pío del Río Hortega (1882-1945) discovered microglia and oligodendrocytes (OLGs), and after Ramón y Cajal, was the most prominent figure of the Spanish school…”
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Isolation, Expansion, and Maturation of Oligodendrocyte Lineage Cells Obtained from Rat Neonatal Brain and Optic Nerve by Sánchez-Gómez, Maria Victoria, Serrano, Mari Paz, Alberdi, Elena, Pérez-Cerdá, Fernando, Matute, Carlos

“…Oligodendrocytes are the myelin-forming cells in the central nervous system (CNS) and their loss or dysfunction is a hallmark of CNS demyelinating diseases,…”
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Gliogenesis from the subventricular zone modulates the extracellular matrix at the glial scar after brain ischemia by Ardaya, Maria, Tiveron, Marie-Catherine, Cremer, Harold, Dehay, Benjamin, Pérez-Cerdá, Fernando, Matute, Carlos, Soria, Federico, Cavaliere, Fabio

“…Activation of the subventricular zone (SVZ) following cerebral ischemia is one of the brain’s early responses to counteract neuron loss and minimize tissue…”
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Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism by Saab, Aiman S., Tzvetavona, Iva D., Trevisiol, Andrea, Baltan, Selva, Dibaj, Payam, Kusch, Kathrin, Möbius, Wiebke, Goetze, Bianka, Jahn, Hannah M., Huang, Wenhui, Steffens, Heinz, Schomburg, Eike D., Pérez-Samartín, Alberto, Pérez-Cerdá, Fernando, Bakhtiari, Davood, Matute, Carlos, Löwel, Siegrid, Griesinger, Christian, Hirrlinger, Johannes, Kirchhoff, Frank, Nave, Klaus-Armin

“…Oligodendrocytes make myelin and support axons metabolically with lactate. However, it is unknown how glucose utilization and glycolysis are adapted to the…”
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Anatomical evidence for glutamate and/or aspartate as neurotransmitters in the geniculo-, claustro-, and cortico-cortical pathways to the cat striate cortex by Pérez-Cerdá, Fernando, Martínez-Millán, Luis, Matute, Carlos

“…Data obtained by using various experimental approaches suggest that in the mammalian brain, most neurons within the visual system projecting to the striate…”
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KA1-like kainate receptor subunit immunoreactivity in neurons and glia using a novel anti-peptide antibody by Fogarty, David J, Pérez-Cerdá, Fernando, Matute, Carlos

“…Functional kainate receptors can be formed by various combinations of subunits with low (GluR5, GluR6 and GluR7) or high affinity (KA1 and KA2) for kainate…”
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P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis by Matute, Carlos, Torre, Iratxe, Pérez-Cerdá, Fernando, Pérez-Samartín, Alberto, Alberdi, Elena, Etxebarria, Estibaliz, Arranz, Amaia M, Ravid, Rivka, Rodríguez-Antigüedad, Alfredo, Sánchez-Gómez, MaríaVictoria, Domercq, María

“…Oligodendrocyte death and demyelination are hallmarks of multiple sclerosis (MS). Here we show that ATP signaling can trigger oligodendrocyte excitotoxicity…”
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Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination by Manterola, Andrea, Bernal-Chico, Ana, Cipriani, Raffaela, Canedo-Antelo, Manuel, Moreno-García, Álvaro, Martín-Fontecha, Mar, Pérez-Cerdá, Fernando, Sánchez-Gómez, María Victoria, Ortega-Gutiérrez, Silvia, Brown, J. Mark, Hsu, Ku-Lung, Cravatt, Benjamin, Matute, Carlos, Mato, Susana

“…[Display omitted] Multiple sclerosis (MS) is a chronic demyelinating disease of unknown etiology in which tissue pathology suggests both immune-dependent…”
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P2X7 Receptor Blockade Prevents ATP Excitotoxicity in Oligodendrocytes and Ameliorates Experimental Autoimmune Encephalomyelitis by Matute, Carlos, Torre, Iratxe, Perez-Cerda, Fernando, Perez-Samartin, Alberto, Alberdi, Elena, Etxebarria, Estibaliz, Arranz, Amaia M, Ravid, Rivka, Rodriguez-Antiguedad, Alfredo, Sanchez-Gomez, MariaVictoria, Domercq, Maria

“…Oligodendrocyte death and demyelination are hallmarks of multiple sclerosis (MS). Here we show that ATP signaling can trigger oligodendrocyte excitotoxicity…”
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Activation of Kainate Receptors Sensitizes Oligodendrocytes to Complement Attack by Alberdi, Elena, Sanchez-Gomez, Maria Victoria, Torre, Iratxe, Domercq, Maria, Perez-Samartin, Alberto, Perez-Cerda, Fernando, Matute, Carlos

“…Glutamate excitotoxicity and complement attack have both been implicated separately in the generation of tissue damage in multiple sclerosis and in its animal…”
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P2X 7 Receptor Blockade Prevents ATP Excitotoxicity in Oligodendrocytes and Ameliorates Experimental Autoimmune Encephalomyelitis by Matute, Carlos, Torre, Iratxe, Pérez-Cerdá, Fernando, Pérez-Samartín, Alberto, Alberdi, Elena, Etxebarria, Estibaliz, Arranz, Amaia M., Ravid, Rivka, Rodríguez-Antigüedad, Alfredo, Sánchez-Gómez, MaríaVictoria, Domercq, María

“…Oligodendrocyte death and demyelination are hallmarks of multiple sclerosis (MS). Here we show that ATP signaling can trigger oligodendrocyte excitotoxicity…”
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