Search Results - "Pérez‐Castells, Javier"

Alkenes in [2+2+2] Cycloadditions by Dominguez, Gema, Perez-Castells, Javier

“…Participation of alkenes and allenes in [2+2+2] cycloaddition reactions has attracted much attention recently. This version of the well‐established alkyne…”
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Macrocyclization by Ring-Closing Metathesis in the Total Synthesis of Natural Products: Reaction Conditions and Limitations by Gradillas, Ana, Pérez-Castells, Javier

“…The construction of macrocycles by ring‐closing metathesis (RCM) is often used as the key step in the synthesis of natural products containing large rings…”
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Straightforward Synthesis of Highly Functionalized Indanes and Tetralines through Ene-Cyclopropene Rearrangement Mediated by Ruthenium by Puet, Alejandro, Domínguez, Gema, Pérez-Castells, Javier

“…Ene-cyclopropenes give functionalized indanes and tetralines in the presence of ruthenium dimeric catalysts. This reaction involves the cyclopropene opening by…”
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Flow Chemistry for Cycloaddition Reactions by García‐Lacuna, Jorge, Domínguez, Gema, Pérez‐Castells, Javier

“…: Continuous flow reactors form part of a rapidly growing research area that has changed the way synthetic chemistry is performed not only in academia but also…”
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One Pot Synthesis of Spirocycles and Cyclopropa[b]pyrans by Alkenylation-Rearrangement of Cyclopropenes by Puet, Alejandro, Giona, Eleonora, Domínguez, Gema, Pérez-Castells, Javier

“…A one pot alkenylation followed by a stereoselective Alder-ene cycloisomerization of cyclopropenes give (aza)­spiro[2.4]­heptanes and spiro[2.5]­octanes in…”
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Ruthenium Catalyzed Rearrangement of Ene-cyclopropenes. Divergent Reaction Pathways by López-Rodríguez, Alberto, Domínguez, Gema, Pérez-Castells, Javier

“…The reaction of ene-cyclopropenes with Cp*RuCl­(cod) leads to alkenyl bicyclo­[3.1.0]­hexanes, bicyclo­[4.1.0]­heptanes, and bicyclo­[5.1.0]­octanes. This…”
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Efficient Generation of Pyridines by Ruthenium Carbene Mediated [2 + 2 + 2] Cyclotrimerization by Medina, Sandra, Domínguez, Gema, Pérez-Castells, Javier

“…Hoveyda–Grubbs’ catalyst is able to catalyze crossed [2 + 2 + 2] cyclotrimerizations of diynes with nitriles. Pyridines are obtained with excellent yields when…”
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Avenues to Characterize the Interactions of Extended N‐Glycans with Proteins by NMR Spectroscopy: The Influenza Hemagglutinin Case by Fernández de Toro, Beatriz, Peng, Wenjie, Thompson, Andrew J., Domínguez, Gema, Cañada, F. Javier, Pérez‐Castells, Javier, Paulson, James C., Jiménez‐Barbero, Jesús, Canales, Ángeles

“…Long‐chain multiantenna N‐glycans are extremely complex molecules. Their inherent flexibility and the presence of repetitions of monosaccharide units in…”
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Cobalt Octacarbonyl-Catalyzed Scalable Alkyne Cyclotrimerization and Crossed [2 + 2 + 2]-Cycloaddition Reaction in a Plug Flow Reactor by García-Lacuna, Jorge, Domínguez, Gema, Blanco-Urgoiti, Jaime, Pérez-Castells, Javier

“…Cobalt-catalyzed alkyne cyclotrimerization and crossed [2 + 2 + 2] cycloadditions are developed in a plug flow reactor. The protocol generally uses 5 mol % of…”
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Breaking Pseudo-Symmetry in Multiantennary Complex N-Glycans Using Lanthanide-Binding Tags and NMR Pseudo-Contact Shifts by Canales, Angeles, Mallagaray, Alvaro, Pérez-Castells, Javier, Boos, Irene, Unverzagt, Carlo, André, Sadine, Gabius, Hans-Joachim, Cañada, Francisco Javier, Jiménez-Barbero, Jesús

“…Controlling NMR shifts by lanthanides tagged to a “symmetrical” N‐glycan (see picture) reveals individual resonances for the residues of the otherwise…”
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Breaking the Limits in Analyzing Carbohydrate Recognition by NMR Spectroscopy: Resolving Branch‐Selective Interaction of a Tetra‐Antennary N‐Glycan with Lectins by Canales, Angeles, Boos, Irene, Perkams, Lukas, Karst, Lukas, Luber, Thomas, Karagiannis, Theodoros, Domínguez, Gemma, Cañada, F. Javier, Pérez‐Castells, Javier, Häussinger, Daniel, Unverzagt, Carlo, Jiménez‐Barbero, Jesus

“…The biological recognition of complex‐type N‐glycans is part of many key physiological and pathological events. Despite their importance, the structural…”
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Synthesis and Evaluation of Novel Iminosugars Prepared from Natural Amino Acids by Puet, Alejandro, Domínguez, Gema, Cañada, Francisco Javier, Pérez-Castells, Javier

“…Cyclopropanated iminosugars have a locked conformation that may enhance the inhibitory activity and selectivity against different glycosidases. We show the…”
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[2+2+2] Cyclotrimerization of Alkynes and Isocyanates/Isothiocyanates Catalyzed by Ruthenium–Alkylidene Complexes by Alvarez, Silvia, Medina, Sandra, Domínguez, Gema, Pérez-Castells, Javier

“…Ruthenium carbene catalysts are able to catalyze crossed [2+2+2] cyclotrimerizations of α,ω-diynes with isocyanates, isothiocyanates, and carbon disulfide…”
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Ruthenium Alkylidene-Catalyzed Reaction of 1,6-Heptadiynes with Alkenes by Alvarez, Silvia, Medina, Sandra, Domínguez, Gema, Pérez-Castells, Javier

“…Ruthenium carbene catalysts are able to catalyze cross [2 + 2 + 2] cyclotrimerizations of 1,6-diynes with cyclic and acyclic double bonds. A plausible…”
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Chemistry of β-Carbolines as Synthetic Intermediates by Domínguez, Gema, Pérez-Castells, Javier

“…β‐Carbolines are present in a wide variety of indole alkaloids that display important biological activities. Here we review the most recent aspects of the…”
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Unraveling the Conformational Landscape of Ligand Binding to Glucose/Galactose-Binding Protein by Paramagnetic NMR and MD Simulations by Unione, Luca, Ortega, Gabriel, Mallagaray, Alvaro, Corzana, Francisco, Pérez-Castells, Javier, Canales, Angeles, Jiménez-Barbero, Jesús, Millet, Oscar

“…Protein dynamics related to function can nowadays be structurally well characterized (i.e., instances obtained by high resolution structures), but they are…”
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Unusual Skeletal Rearrangement of Unsaturated Seven-Membered Lactams into Fused Pyrrolidinolactones by Álvarez, Silvia, Domínguez, Gema, Gradillas, Ana, Pérez-Castells, Javier

“…Unsaturated ϵ‐lactams undergo a novel process involving a skeletal reorganization to give fused pyrrolidine‐lactones by reaction with aromatic α‐bromo ketones…”
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Hydroxy Chalcogenide-Promoted Morita-Baylis-Hillman Alkylation Reaction: Intermolecular Applications with Alkyl Halides as Electrophiles by Gradillas, Ana, Belmonte, Efres, da Silva, Rondes Ferreira, Pérez-Castells, Javier

“…Hydroxysulfides acted as catalysts to promote the Morita–Baylis–Hillman alkylation reaction of cyclohexenones and dihydropyridinones. The procedure worked…”
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Effect of Lauric vs. Oleic Acid-Enriched Diets on Leptin Autoparacrine Signalling in Male Mice by Fernández-Felipe, Jesús, Plaza, Adrián, Domínguez, Gema, Pérez-Castells, Javier, Cano, Victoria, Cioni, Francesco, Del Olmo, Nuria, Ruiz-Gayo, Mariano, Merino, Beatriz

“…High-fat diets enriched with lauric acid (SOLF) do not enhance leptin production despite expanding white adipose tissue (WAT). Our study aimed at identifying…”
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Synthesis of Benzazepines by Gold‐Catalysed Reactions of N‐Allenylamides by GONZALEZ-GOMEZ, Alvaro, DOMINGUEZ, Gema, PEREZ-CASTELLS, Javier

“…The gold‐catalysed reactions of alleneamides give different products depending on the substrate and the reaction conditions. In particular,…”
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