Search Results - "Pérez, Néstor G"

Myocardial Mineralocorticoid Receptor Activation by Stretching and Its Functional Consequences by Díaz, Romina G, Pérez, Néstor G, Morgan, Patricio E, Villa-Abrille, María C, Caldiz, Claudia I, Nolly, Mariela B, Portiansky, Enrique L, Ennis, Irene L, Cingolani, Horacio E

“…Myocardial stretch triggers an angiotensin II–dependent autocrine/paracrine loop of intracellular signals, leading to reactive oxygen species–mediated…”
Get full text

The Anrep effect requires transactivation of the epidermal growth factor receptor by Villa‐Abrille, María C., Caldiz, Claudia I., Ennis, Irene L., Nolly, Mariela B., Casarini, María J., Chiappe de Cingolani, Gladys E., Cingolani, Horacio E., Pérez, Néstor G.

“…Myocardial stretch elicits a biphasic contractile response: the Frank–Starling mechanism followed by the slow force response (SFR) or Anrep effect. In this…”
Get full text

p38-MAP Kinase Negatively Regulates the Slow Force Response to Stretch in Rat Myocardium through the Up-Regulation of Dual Specificity Phosphatase 6 (DUSP6) by Zavala, Maite R, Díaz, Romina G, Medina, Andrés J, Acosta, María P, Escudero, Daiana S, Ennis, Irene L, Pérez, Néstor G, Villa-Abrille, María C

“…Myocardial stretch increases cardiac force in two consecutive phases: The first one due to Frank-Starling mechanism, followed by the gradually developed slow…”
Get full text

In vivo key role of reactive oxygen species and NHE-1 activation in determining excessive cardiac hypertrophy by Cingolani, Oscar H., Pérez, Néstor G., Ennis, Irene L., Álvarez, María C., Mosca, Susana M., Schinella, Guillermo R., Escudero, Eduardo M., Cónsole, Gloria, Cingolani, Horacio E.

“…Growing in vitro evidence suggests NHE-1, a known target for reactive oxygen species (ROS), as a key mediator in cardiac hypertrophy (CH). Moreover, NHE-1…”
Get full text

Mitochondrial reactive oxygen species activate the slow force response to stretch in feline myocardium by Caldiz, Claudia I., Garciarena, Carolina D., Dulce, Raúl A., Novaretto, Leonardo P., Yeves, Alejandra M., Ennis, Irene L., Cingolani, Horacio E., Chiappe de Cingolani, Gladys, Pérez, Néstor G.

“…When the length of the myocardium is increased, a biphasic response to stretch occurs involving an initial rapid increase in force followed by a delayed slow…”
Get full text

Regression of Hypertensive Myocardial Fibrosis by Na+/H+ Exchange Inhibition by Cingolani, Horacio E, Rebolledo, Oscar R, Portiansky, Enrique L, Pérez, Néstor G, Camilión de Hurtado, María C

“…ABSTRACT—We have recently reported that the inhibition of the Na/H exchanger (NHE) during 1 month in spontaneously hypertensive rats (SHR) is followed by…”
Get full text

Reverse Mode of the Na+-Ca2+ Exchange After Myocardial Stretch: Underlying Mechanism of the Slow Force Response by Pérez, Néstor G, Camilión de Hurtado, María C, Cingolani, Horacio E

“…ABSTRACT—This study was designed to gain additional insight into the mechanism of the slow force response (SFR) to stretch of cardiac muscle. SFR and changes…”
Get full text

Intracellular signaling following myocardial stretch: an autocrine/paracrine loop by Cingolani, Horacio E., Pérez, Néstor G., Aiello, Ernesto A., Camilión de Hurtado, María C.

“…The stretch of adult papillary muscle elicits a chain of autocrine/paracrine events in which the Na +/H + exchanger (NHE-1) activation is the central step…”
Get full text

Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger by CAMILION DE HURTADO, Maria C, PORTIANSKY, Enrique L, PEREZ, Néstor G, REBOLLEDO, Oscar R, CINGOLANI, Horacio E

“…Experiments were performed to examine the effect of chronic inhibition of the Na(+)/H(+) exchanger isoform-1 (NHE-1) on cardiac hypertrophy of spontaneously…”
Get full text

Endothelin isoforms and the response to myocardial stretch by Ennis, Irene L, Garciarena, Carolina D, Pérez, Néstor G, Dulce, Raúl A, Camilión de Hurtado, María C, Cingolani, Horacio E

“…Myocardial stretch elicits a biphasic increase in developed force with a first rapid force response and a second slow force response (SFR). The rapid phase is…”
Get more information

Myocardial hypertrophy of normotensive Wistar-Kyoto rats by Aiello, Ernesto A, Villa-Abrille, María C, Escudero, Eduardo M, Portiansky, Enrique L, Pérez, Néstor G, de Hurtado, María C Camilión, Cingolani, Horacio E

“…In our studies with spontaneously hypertensive (SHR), Wistar-Kyoto (WKY), and Wistar rats, we observed normotensive WKY rats with cardiac hypertrophy…”
Get more information

Physiological cardiac hypertrophy: Critical role of AKT in the prevention of NHE-1 hyperactivity by Yeves, Alejandra M, Villa-Abrille, María C, Pérez, Néstor G, Medina, Andrés J, Escudero, Eduardo M, Ennis, Irene L

“…Abstract Background The involvement of NHE-1 hyperactivity, critical for pathological cardiac hypertrophy (CH), in physiological CH has not been elucidated…”
Get full text

Stretch-elicited Na+/H+ exchanger activation: the autocrine/paracrine loop and its mechanical counterpart by CINGOLANI, Horacio E, PEREZ, Néstor G, PIESKE, Burket, VON LEWINSKI, Dirk, CAMILION DE HURTADO, Maria C

“…The stretch of the cardiac muscle is immediately followed by an increase in the contraction strength after which occurs a slow force increase (SFR) that takes…”
Get full text

Acute and specific collagen type I degradation increases diastolic and developed tension in perfused rat papillary muscle by Lamberts, Regis R, Willemsen, Maurice J J M F, Pérez, Néstor G, Sipkema, Pieter, Westerhof, Nico

“…Collagen degradation is suggested to be responsible for long-term contractile dysfunction in different cardiomyopathies, but the effects of acute and specific…”
Get more information

Mechanisms Underlying the Increase in Force and Ca2+ Transient That Follow Stretch of Cardiac Muscle: A Possible Explanation of the Anrep Effect by Alvarez, Bernardo V, Pérez, Néstor G, Ennis, Irene L, de Hurtado, María C. Camilión, Cingolani, Horacio E

“…Myocardial stretch produces an increase in developed force (DF) that occurs in two phasesthe first (rapidly occurring) is generally attributed to an increase…”
Get full text

The Anrep effect: 100 years later by Cingolani, Horacio E, Pérez, Néstor G, Cingolani, Oscar H, Ennis, Irene L

“…Myocardial stretch elicits a rapid increase in developed force, which is mainly caused by an increase in myofilament calcium sensitivity (Frank-Starling…”
Get more information

A low dose of angiotensin II increases inotropism through activation of reverse Na(+)/Ca(2+) exchange by endothelin release by Pérez, Néstor G, Villa-Abrille, María C, Aiello, Ernesto A, Dulce, Raúl A, Cingolani, Horacio E, Camilión de Hurtado, María C

“…This work was aimed to prove that release/formation of endogenous endothelin acting in an autocrine/paracrine fashion contributes to the increase in…”
Get full text

Benzolamide perpetuates acidic conditions during reperfusion and reduces myocardial ischemia-reperfusion injury by Ciocci Pardo, Alejandro, Díaz, Romina G, González Arbeláez, Luisa F, Perez, Nestor G, Swenson, Erik Richard, Mosca, Susana M, Alvarez, Bernardo V

“…During ischemia, increased anaerobic glycolysis results in intracellular acidosis. Activation of alkalinizing transport mechanisms associated with carbonic…”
Get full text

Hydrocortisone cardioprotection in ischaemia/reperfusion injury involves antioxidant mechanisms by Escudero, Daiana S., Fantinelli, Juliana C., Martínez, Valeria R., González Arbeláez, Luisa F., Amarillo, María E., Pérez, Néstor G., Díaz, Romina G.

“…Background Glucocorticoid (GR) and mineralocorticoid (MR) receptors are highly expressed in cardiac tissue, and both can be activated by corticosteroids. MR…”
Get full text

PDE5 inhibition improves cardiac morphology and function in SHR by reducing NHE1 activity: Repurposing Sildenafil for the treatment of hypertensive cardiac hypertrophy by Escudero, Daiana S., Brea, María S., Caldiz, Claudia I., Amarillo, María E., Aranda, Jorge O., Portiansky, Enrique L., Pérez, Néstor G., Díaz, Romina G.

“…Previously, we have shown that an increased cGMP-activated protein Kinase (PKG) activity after phosphodiesterase 5 (PDE5) inhibition by Sildenafil (SIL), leads…”
Get full text