Search Results - "Pérez, Julio Enríquez"
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Intratumoral administration of the antisecretory peptide AF16 cures murine gliomas and modulates macrophage functions
Published in Scientific reports (17-03-2022)“…Glioblastoma has remained the deadliest primary brain tumor while its current therapy offers only modest survival prolongation. Immunotherapy has failed to…”
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Landscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization
Published in Proceedings of the National Academy of Sciences - PNAS (01-03-2022)“…Therapeutic strategies directed at the tumor surfaceome (TS), including checkpoint inhibitor blocking antibodies, antibody drug conjugates (ADCs), and chimeric…”
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Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration
Published in Journal of experimental & clinical cancer research (07-06-2019)“…Primary brain tumors, in particular glioblastoma (GBM), remain among the most challenging cancers. Like most malignant tumors, GBM is characterized by hypoxic…”
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Preoperative systemic levels of VEGFA, IL-7, IL-17A, and TNF-β delineate two distinct groups of children with brain tumors
Published in Pediatric blood & cancer (01-12-2016)“…Background Primary brain tumors are the most common solid tumors in children. Increasing evidence demonstrates diverse intratumoral immune signatures, which…”
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Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation
Published in Scientific reports (18-04-2017)“…Medulloblastomas comprise a heterogeneous group of tumours and can be subdivided into four molecular subgroups (WNT, SHH, Group 3 and Group 4) with distinct…”
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The effect of locally delivered cisplatin is dependent on an intact immune function in an experimental glioma model
Published in Scientific reports (04-04-2019)“…Several chemotherapeutic drugs are now considered to exert anti-tumour effects, by inducing an immune-promoting inflammatory response. Cisplatin is a potent…”
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Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomas
Published in BMC cancer (03-01-2020)“…Glioblastomas (GBM) are therapy-resistant tumors with a profoundly immunosuppressive tumor microenvironment. Chemotherapy has shown limited efficacy against…”
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Preoperative systemic levels of VEGFA, IL-7, IL-17A, and TNF-[beta] delineate two distinct groups of children with brain tumors
Published in Pediatric blood & cancer (01-12-2016)“…Background Primary brain tumors are the most common solid tumors in children. Increasing evidence demonstrates diverse intratumoral immune signatures, which…”
Get full text
Journal Article