Search Results - "Pélaez, Rafael"

Panobinostat Synergistically Enhances the Cytotoxicity of Microtubule Destabilizing Drugs in Ovarian Cancer Cells by Ovejero-Sánchez, María, Asensio-Juárez, Gloria, González, Myriam, Puebla, Pilar, Vicente-Manzanares, Miguel, Pélaez, Rafael, González-Sarmiento, Rogelio, Herrero, Ana Belén

“…Ovarian cancer (OC) is one of the most common gynecologic neoplasia and has the highest mortality rate, which is mainly due to late-stage diagnosis and…”
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Characterization of three-dimensional cancer cell migration in mixed collagen-Matrigel scaffolds using microfluidics and image analysis by Anguiano, María, Castilla, Carlos, Maška, Martin, Ederra, Cristina, Peláez, Rafael, Morales, Xabier, Muñoz-Arrieta, Gorka, Mujika, Maite, Kozubek, Michal, Muñoz-Barrutia, Arrate, Rouzaut, Ana, Arana, Sergio, Garcia-Aznar, José Manuel, Ortiz-de-Solorzano, Carlos

“…Microfluidic devices are becoming mainstream tools to recapitulate in vitro the behavior of cells and tissues. In this study, we use microfluidic devices…”
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Novel Tetrazole Derivatives Targeting Tubulin Endowed with Antiproliferative Activity against Glioblastoma Cells by Gallego-Yerga, Laura, Chiliquinga, Andrea Jazmín, Peláez, Rafael

“…Increasing awareness of the structure of microtubules has made tubulin a relevant target for the research of novel chemotherapies. Furthermore, the…”
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Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target by Vicente‐Blázquez, Alba, González, Myriam, Álvarez, Raquel, del Mazo, Sara, Medarde, Manuel, Peláez, Rafael

“…Tubulin, the microtubules and their dynamic behavior are amongst the most successful antitumor, antifungal, antiparasitic, and herbicidal drug targets…”
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Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells by Álvarez, Raquel, Gajate, Consuelo, Puebla, Pilar, Mollinedo, Faustino, Medarde, Manuel, Peláez, Rafael

“…Resistance to combretastatin A-4 is mediated by metabolic modification of the phenolic hydroxyl and ether groups of the 3-hydroxy-4-methoxyphenyl (B ring)…”
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Potent and Selective Benzothiazole-Based Antimitotics with Improved Water Solubility: Design, Synthesis, and Evaluation as Novel Anticancer Agents by Gallego-Yerga, Laura, Ceña, Valentín, Peláez, Rafael

“…The design of colchicine site ligands on tubulin has proven to be a successful strategy to develop potent antiproliferative drugs against cancer cells…”
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Frentizole, a Nontoxic Immunosuppressive Drug, and Its Analogs Display Antitumor Activity via Tubulin Inhibition by Ramos, Sergio, Vicente-Blázquez, Alba, López-Rubio, Marta, Gallego-Yerga, Laura, Álvarez, Raquel, Peláez, Rafael

“…Antimitotic agents are one of the more successful types of anticancer drugs, but they suffer from toxicity and resistance. The application of approved drugs to…”
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Experimental structure based drug design (SBDD) applications for anti‐leishmanial drugs: A paradigm shift? by Marín, Miguel, López, Marta, Gallego‐Yerga, Laura, Álvarez, Raquel, Peláez, Rafael

“…Leishmaniasis is a group of neglected tropical diseases caused by at least 20 species of Leishmania protozoa, which are spread by the bite of infected…”
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Segmentation of the ECG Signal by Means of a Linear Regression Algorithm by Aspuru, Javier, Ochoa-Brust, Alberto, Félix, Ramón A, Mata-López, Walter, Mena, Luis J, Ostos, Rodolfo, Martínez-Peláez, Rafael

“…The monitoring and processing of electrocardiogram (ECG) beats have been actively studied in recent years: new lines of research have even been developed to…”
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Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues by Pecnard, Shannon, Hamze, Abdallah, Bignon, Jérome, Prost, Bastien, Deroussent, Alain, Gallego-Yerga, Laura, Peláez, Rafael, Paik, Ji Yeon, Diederich, Marc, Alami, Mouad, Provot, Olivier

“…In this study, a variety of original ligands related to Combretastatin A-4 and isoCombretastatin A-4, able to inhibit the tubulin polymerization into…”
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Editorial: Pharmacoinformatics: new developments and challenges in drug design by Ramírez, David, Peláez, Rafael, Lagos, Carlos F, Medina-Franco, José L

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New ligands of the tubulin colchicine site based on X-ray structures by Álvarez, Raquel, Medarde, Manuel, Peláez, Rafael

“…Colchicine site ligands have proved to be potent inhibitors of tubulin polymerization, which leads them not only to display cytotoxic effects but also vascular…”
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Identification of 7-Ketocholesterol-Modulated Pathways and Sterculic Acid Protective Effect in Retinal Pigmented Epithelium Cells by Using Genome-Wide Transcriptomic Analysis by Pariente, Ana, Pérez-Sala, Álvaro, Ochoa, Rodrigo, Bobadilla, Miriam, Villanueva-Martínez, Ángela, Peláez, Rafael, Larráyoz, Ignacio M

“…Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. AMD is characterized by the formation of lipidic deposits…”
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An Enhanced Lightweight IoT-based Authentication Scheme in Cloud Computing Circumstances by Martínez-Peláez, Rafael, Toral-Cruz, Homero, Parra-Michel, Jorge R, García, Vicente, Mena, Luis J, Félix, Vanessa G, Ochoa-Brust, Alberto

“…With the rapid deployment of the Internet of Things and cloud computing, it is necessary to enhance authentication protocols to reduce attacks and security…”
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The Bateman domain of IMP dehydrogenase is a binding target for dinucleoside polyphosphates by Fernández-Justel, David, Peláez, Rafael, Revuelta, José Luis, Buey, Rubén M.

“…IMP dehydrogenase (IMPDH) is an essential enzyme that catalyzes the rate-limiting step in the de novo guanine nucleotide biosynthetic pathway. Because of its…”
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Inflammatory and cell death mechanisms induced by 7-ketocholesterol in the retina. Implications for age-related macular degeneration by Pariente, Ana, Peláez, Rafael, Pérez-Sala, Álvaro, Larráyoz, Ignacio M.

“…This review will focus on the inflammatory and toxic mechanism of action of 7-ketocholesterol (7KCh) and the potential implications of its accumulation,…”
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Fast Parabolic Fitting: An R-Peak Detection Algorithm for Wearable ECG Devices by Félix, Ramón A, Ochoa-Brust, Alberto, Mata-López, Walter, Martínez-Peláez, Rafael, Mena, Luis J, Valdez-Velázquez, Laura L

“…Heart diseases rank among the most fatal health concerns globally, with the majority being preventable through early diagnosis and effective treatment…”
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Promising anti-proliferative indolic benzenesulfonamides alter mechanisms with sulfonamide nitrogen substituents by Fuentes-Martín, Raúl, Ayuda-Durán, Pilar, Hanes, Robert, Gallego-Yerga, Laura, Wolterinck, Lisanne, Enserink, Jorrit M., Álvarez, Raquel, Peláez, Rafael

“…Agents that cause apoptotic cell death by interfering with tubulin dynamics, such as vinblastine and paclitaxel, are an important class of chemotherapeutics…”
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Functional domains of yeast hexokinase 2 by Peláez, Rafael, Herrero, Pilar, Moreno, Fernando

“…Hkx2 (hexokinase 2) from Saccharomyces cerevisiae was one of the first metabolic enzymes described as a multifunctional protein. Hxk2 has a double subcellular…”
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Phosphorylation of Yeast Hexokinase 2 Regulates Its Nucleocytoplasmic Shuttling by Fernández-García, Paula, Peláez, Rafael, Herrero, Pilar, Moreno, Fernando

“…Nucleocytoplasmic shuttling of Hxk2 induced by glucose levels has been reported recently. Here we present evidence that indicates that Hxk2 nucleocytoplasmic…”
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