Search Results - "Páramo, José A"

Treatment of haemophilia: From replacement to gene therapy by Páramo, José A

“…Haemophilia A and B are congenital bleeding disorders characterized by missing or defective factor VIII or factor IX, respectively. Factor replacement therapy…”
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Factor XI inhibitors: A new era in antithrombotic therapy by Páramo, José A, Marcos-Jubilar, María

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Prediction and treatment of bleeding in patients under anticoagulant treatment by Páramo, José A

“…Major bleeding is a common complication of anticoagulant treatment. Risk assessment tools are relevant in the management of patients with atrial fibrillation…”
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Pulmonary Embolism, Pulmonary Microvascular Thrombosis, or Both in COVID-19? by Páramo, José A.

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Immunothrombosis: Molecular Aspects and New Therapeutic Perspectives by Marcos-Jubilar, María, Lecumberri, Ramón, Páramo, José A

“…Thromboinflammation or immunothrombosis is a concept that explains the existing link between coagulation and inflammatory response present in many situations,…”
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Association of sepsis-related mortality with early increase of TIMP-1/MMP-9 ratio by Lorente, Leonardo, Martín, María M, Solé-Violán, Jordi, Blanquer, José, Labarta, Lorenzo, Díaz, César, Borreguero-León, Juan M, Orbe, Josune, Rodríguez, José A, Jiménez, Alejandro, Páramo, José A

“…Higher circulating levels of tissue inhibitor of matrix metalloproteinases (TIMP)-1 at the time of severe sepsis diagnosis have been reported in nonsurviving…”
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MMP‐10 Is Required for Efficient Muscle Regeneration in Mouse Models of Injury and Muscular Dystrophy by Bobadilla, Míriam, Sáinz, Neira, Rodriguez, José Antonio, Abizanda, Gloria, Orbe, Josune, Martino, Alba, García Verdugo, José Manuel, Páramo, José A., Prósper, Felipe, Pérez‐Ruiz, Ana

“…Matrix metalloproteinases (MMPs), a family of endopeptidases that are involved in the degradation of extracellular matrix components, have been implicated in…”
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Matrix metalloproteinase-10 deficiency delays atherosclerosis progression and plaque calcification by Purroy, Ana, Roncal, Carmen, Orbe, Josune, Meilhac, Olivier, Belzunce, Miriam, Zalba, Guillermo, Villa-Bellosta, Ricardo, Andrés, Vicente, Parks, William C., Páramo, José A., Rodríguez, José A.

“…Matrix metalloproteinases (MMPs) have been implicated in atherosclerosis and vascular calcification. Among them, we reported that MMP10 is present in human…”
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Maintained effectiveness of an electronic alert system to prevent venous thromboembolism among hospitalized patients by Lecumberri, Ramón, Marqués, Margarita, Díaz-Navarlaz, María Teresa, Panizo, Elena, Toledo, Jon, García-Mouriz, Alberto, Páramo, José A

“…Despite current guidelines, venous thromboembolism (VTE) prophylaxis is underused. Computerized programs to encourage physicians to apply thromboprophylaxis…”
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Synergistic Effect of Thrombin and CD40 Ligand on Endothelial Matrix Metalloproteinase-10 Expression and Microparticle Generation In Vitro and In Vivo by de Lizarrondo, Sara Martínez, Roncal, Carmen, Calvayrac, Olivier, Rodríguez, Cristina, Varo, Nerea, Purroy, Ana, Lorente, Leonardo, Rodríguez, José A, Doeuvre, Loïc, Hervás-Stubbs, Sandra, Angles-Cano, Eduardo, Páramo, José A, Martínez-González, José, Orbe, Josune

“…OBJECTIVE—Thrombin induces CD40 ligand (CD40L) and matrix metalloproteinases (MMPs) under inflammatory/prothrombotic conditions. Thrombin and CD40L could…”
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Tissue factor expressed by microparticles is associated with mortality but not with thrombosis in cancer patients by Hernández, C, Orbe, J, Roncal, C, Alvarez-Hernandez, M, Martinez de Lizarrondo, S, Alves, M T, García Mata, J, Páramo, J A

“…A prothrombotic state is one of the hallmarks of malignancy and a major contributor to morbidity and mortality in cancer patients.Tissue factor (TF) is often…”
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Persistently high circulating tissue inhibitor of matrix metalloproteinase-1 levels in non-survivor brain trauma injury patients by Lorente, Leonardo, Martín, María M., Ramos, Luis, Argueso, Mónica, Cáceres, Juan J., Solé-Violán, Jordi, Jiménez, Alejandro, Borreguero-León, Juan M., González-Rivero, Agustín F., Orbe, Josune, Rodríguez, José A., Páramo, José A.

“…Previously, higher circulating levels of matrix metalloproteinase (MMP)-9 and tissue inhibitor matrix metalloproteinases (TIMP)-1 were reported in the first…”
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Design, Synthesis, and Biological Evaluation of Novel Matrix Metalloproteinase Inhibitors As Potent Antihemorrhagic Agents: From Hit Identification to an Optimized Lead by Orbe, Josune, Sánchez-Arias, Juan A, Rabal, Obdulia, Rodríguez, José A, Salicio, Agustina, Ugarte, Ana, Belzunce, Miriam, Xu, Musheng, Wu, Wei, Tan, Haizhong, Ma, Hongyu, Páramo, José A, Oyarzabal, Julen

“…Growing evidence suggests that matrix metalloproteinases (MMP) are involved in thrombus dissolution; then, considering that new therapeutic strategies are…”
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Spanish Consensus Statement on alternatives to allogeneic blood transfusion: the 2013 update of the "Seville Document" by Leal-Noval, Santiago R, Muñoz, Manuel, Asuero, Marisol, Contreras, Enric, García-Erce, José A, Llau, Juan V, Moral, Victoria, Páramo, José A, Quintana, Manuel

“…Summary of recommendations on alternatives to reduce allogeneic blood transfusion (in descending order of strength)…”
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Screening for occult malignancy with FDG‐PET/CT in patients with unprovoked venous thromboembolism by Alfonso, Ana, Redondo, Margarita, Rubio, Tomás, Del Olmo, Beatriz, Rodríguez‐Wilhelmi, Pablo, García‐Velloso, María J., Richter, José A., Páramo, José A., Lecumberri, Ramón

“…Extensive screening strategies to detect occult cancer in patients with unprovoked venous thromboembolism (VTE) are complex and no benefit in terms of survival…”
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High incidence of venous thromboembolism despite electronic alerts for thromboprophylaxis in hospitalised cancer patients by Lecumberri, Ramón, Marqués, Margarita, Panizo, Elena, Alfonso, Ana, García-Mouriz, Alberto, Gil-Bazo, Ignacio, Hermida, José, Schulman, Sam, Páramo, José A

“…Many cancer patients are at high risk of venous thromboembolism (VTE) during hospitalisation; nevertheless, thromboprophylaxis is frequently underused…”
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Matrix Metalloproteinase-10 Is Upregulated by Thrombin in Endothelial Cells and Increased in Patients With Enhanced Thrombin Generation by Orbe, Josune, Rodríguez, José A, Calvayrac, Olivier, Rodríguez-Calvo, Ricardo, Rodríguez, Cristina, Roncal, Carmen, de Lizarrondo, Sara Martínez, Barrenetxe, Jaione, Reverter, Juan C, Martínez-González, José, Páramo, José A

“…OBJECTIVE—Thrombin is a multifunctional serine protease that promotes vascular proinflammatory responses whose effect on endothelial MMP-10 expression has not…”
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Association between serum tissue inhibitor of matrix metalloproteinase-1 levels and mortality in patients with severe brain trauma injury by Lorente, Leonardo, Martín, María M, López, Patricia, Ramos, Luis, Blanquer, José, Cáceres, Juan J, Solé-Violán, Jordi, Solera, Jorge, Cabrera, Judith, Argueso, Mónica, Ortiz, Raquel, Mora, María L, Lubillo, Santiago, Jiménez, Alejandro, Borreguero-León, Juan M, González, Agustín, Orbe, Josune, Rodríguez, José A, Páramo, José A

“…Matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) play a role in neuroinflammation after brain trauma injury (TBI)…”
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C-reactive protein induces matrix metalloproteinase-1 and -10 in human endothelial cells: implications for clinical and subclinical atherosclerosis by Montero, Ines, Orbe, Josune, Varo, Nerea, Beloqui, Oscar, Monreal, José I, Rodríguez, José A, Díez, Javier, Libby, Peter, Páramo, José A

“…We examined the effect of C-reactive protein (CRP) on matrix metalloproteinase (MMP) and inhibitor expression in endothelial cells and in patients with…”
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The Hemostatic System as a Modulator of Atherosclerosis by Páramo, José A

“…To the Editor: In their review article (May 5 issue), 1 Borisoff et al. describe the role of hemostatic mechanisms as potential modulators of atherosclerotic…”
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