Search Results - "Pákai, Eszter"
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Macrophage migration inhibitory factor as a diagnostic and predictive biomarker in sepsis: meta-analysis of clinical trials
Published in Scientific reports (13-04-2021)“…The hunt for useful sepsis biomarkers is ongoing. Macrophage migration inhibitory factor (MIF) was implicated as a biomarker in sepsis, but its diagnostic and…”
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Distinct patterns of serum and urine macrophage migration inhibitory factor kinetics predict death in sepsis: a prospective, observational clinical study
Published in Scientific reports (11-01-2023)“…Macrophage migration inhibitory factor (MIF) has been considered as a biomarker in sepsis, however the predictive value of the pattern of its kinetics in the…”
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3
Predictive value of tachycardia for mortality in trauma-related haemorrhagic shock: a systematic review and meta-regression
Published in BMJ open (19-10-2022)“…ObjectivesHeart rate (HR) is one of the physiological variables in the early assessment of trauma-related haemorrhagic shock, according to Advanced Trauma Life…”
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Systemic antibiotic prophylaxis does not affect infectious complications in pediatric burn injury: A meta-analysis
Published in PloS one (25-09-2019)“…In pediatric burns the use of systemic antibiotic prophylaxis is a standard procedure in some burn centers, though its beneficial effect on the infectious…”
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Synthesis and evaluation of a new class of MIF-inhibitors in activated macrophage cells and in experimental septic shock in mice
Published in European journal of medicinal chemistry (05-02-2023)“…Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with enzymatic activities. Anti-inflammatory effects of MIF enzyme inhibitors…”
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Contributions of Different Modes of TRPV1 Activation to TRPV1 Antagonist-Induced Hyperthermia
Published in The Journal of neuroscience (27-01-2010)“…Transient receptor potential vanilloid-1 (TRPV1) antagonists are widely viewed as next-generation pain therapeutics. However, these compounds cause…”
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Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents
Published in Anesthesiology (Philadelphia) (01-11-2017)“…BACKGROUND:Intraoperative hypothermia and postoperative pain control are two important clinical challenges in anesthesiology. Transient receptor potential…”
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8
Stereolithography 3D Printing of a Heat Exchanger for Advanced Temperature Control in Wire Myography
Published in Polymers (25-01-2022)“…We report the additive manufacturing of a heat-exchange device that can be used as a cooling accessory in a wire myograph. Wire myography is used for measuring…”
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The Hypothermic Effect of Hydrogen Sulfide Is Mediated by the Transient Receptor Potential Ankyrin-1 Channel in Mice
Published in Pharmaceuticals (Basel, Switzerland) (29-09-2021)“…Hydrogen sulfide (H S) has been shown in previous studies to cause hypothermia and hypometabolism in mice, and its thermoregulatory effects were subsequently…”
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The Neurokinin-1 Receptor Contributes to the Early Phase of Lipopolysaccharide-Induced Fever via Stimulation of Peripheral Cyclooxygenase-2 Protein Expression in Mice
Published in Frontiers in immunology (05-02-2018)“…Neurokinin (NK) signaling is involved in various inflammatory processes. A common manifestation of systemic inflammation is fever, which is usually induced in…”
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Aging reverses the role of the transient receptor potential vanilloid-1 channel in systemic inflammation from anti-inflammatory to proinflammatory
Published in Cell cycle (Georgetown, Tex.) (15-01-2012)“…Studies in young rodents have shown that the transient receptor potential vanilloid-1 (TRPV1) channel plays a suppressive role in the systemic inflammatory…”
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Characterization of the Thermoregulatory Response to Pituitary Adenylate Cyclase-Activating Polypeptide in Rodents
Published in Journal of molecular neuroscience (01-11-2014)“…Administration of the long form (38 amino acids) of pituitary adenylate cyclase-activating polypeptide (PACAP38) into the central nervous system causes…”
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13
Investigation of the Receptorial and Molecular Mediators of Systemic Inflammation in Different Animal Models
Published 01-01-2020“…1) We showed that hyperbilirubinemia in J/J Gunn rats was associated with a marked exaggeration of the early hypothermic response to the high dose of LPS,…”
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Dissertation -
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Ammonium chloride-induced hypothermia is attenuated by transient receptor potential channel vanilloid-1, but augmented by ankyrin-1 in rodents
Published in Life sciences (1973) (01-06-2024)“…Systemic administration of ammonium chloride (NH4Cl), an acidifying agent used in human patients and experimental conditions, causes hypothermia in mice,…”
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15
Effectiveness of four topical treatment methods in a rat model of superficial partial-thickness burn injury: the advantages of combining zinc-hyaluronan gel with silver foam dressing
Published in Injury (01-12-2022)“…•A new rat model for superficial partial-thickness burns was developed.•Comparative testing of four different treatment protocols was performed.•Burn wound…”
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Dietary supplementation of transient receptor potential vanilloid-1 channel agonists reduces serum total cholesterol level: a meta-analysis of controlled human trials
Published in Critical reviews in food science and nutrition (01-09-2022)“…Abnormal cholesterol level is a major risk factor in the development of atherosclerosis, which is a fundamental derangement in cardiovascular diseases. Any…”
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POLAR Study Revisited: Therapeutic Hypothermia in Severe Brain Trauma Should Not Be Abandoned
Published in Journal of neurotrauma (01-10-2021)“…The benefits of therapeutic hypothermia (TH) in severe traumatic brain injury (sTBI) have been long debated. In 2018, the POLAR study, a high-quality…”
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18
The hyperthermic effect of central cholecystokinin is mediated by the cyclooxygenase-2 pathway
Published in American journal of physiology: endocrinology and metabolism (01-01-2022)“…Cholecystokinin (CCK) increases core body temperature via CCK receptors when administered intracerebroventricularly (icv). The mechanisms of CCK-induced…”
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Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis
Published in The Journal of neuroscience (02-02-2011)“…This study aimed at determining the thermoregulatory phenotype of mice lacking transient receptor potential vanilloid-1 (TRPV1) channels. We used Trpv1…”
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Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents
Published in The Journal of neuroscience (26-03-2014)“…The rodent transient receptor potential ankyrin-1 (TRPA1) channel has been hypothesized to serve as a temperature sensor for thermoregulation in the cold. We…”
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