Search Results - "PÅHLMAN, S"

The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V by Agarwal, S, Kazi, J U, Mohlin, S, Påhlman, S, Rönnstrand, L

“…Oncogenic c-Kit mutations have been shown to display ligand-independent receptor activation and cell proliferation. A substitution of aspartate to valine at…”
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The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner by Sun, J, Mohlin, S, Lundby, A, Kazi, J U, Hellman, U, Påhlman, S, Olsen, J V, Rönnstrand, L

“…PI3-kinase has a crucial role in transformation mediated by the oncogenic c-Kit mutant D816V. In this study, we demonstrate that the c-Kit/D816V-mediated cell…”
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High levels of HIF-2α highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche by Pietras, A, Gisselsson, D, Øra, I, Noguera, R, Beckman, S, Navarro, S, Påhlman, S

“…High HIF-2α protein levels in the sympathetic nervous system-derived childhood tumour neuroblastoma as well as immature phenotype correlate to unfavourable…”
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TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival by Chavali, P L, Saini, R K R, Zhai, Q, Vizlin-Hodzic, D, Venkatabalasubramanian, S, Hayashi, A, Johansson, E, Zeng, Z-j, Mohlin, S, Påhlman, S, Hansford, L, Kaplan, D R, Funa, K

“…Nuclear orphan receptor TLX ( Drosophila tailless homolog) is essential for the maintenance of neural stem/progenitor cell self-renewal, but its role in…”
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Hypoxia Alters Gene Expression in Human Neuroblastoma Cells toward an Immature and Neural Crest-like Phenotype by Jögi, Annika, Øra, Ingrid, Nilsson, Helén, Lindeheim, Åsa, Makino, Yuichi, Poellinger, Lorenz, Axelson, Håkan, Påhlman, Sven

“…Insufficient oxygen and nutrient supply often restrain solid tumor growth, and the hypoxia-inducible factors (HIF) 1α and HIF-2α are key transcription…”
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Induction of ID2 expression by hypoxia-inducible factor-1: a role in dedifferentiation of hypoxic neuroblastoma cells by Löfstedt, Tobias, Jögi, Annika, Sigvardsson, Mikael, Gradin, Katarina, Poellinger, Lorenz, Påhlman, Sven, Axelson, Håkan

“…ID (inhibitor of differentiation/DNA binding) proteins, frequently deregulated in advanced human malignancies, can participate in multiple fundamental traits…”
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From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia by Hoogewijs, D., Terwilliger, N. B., Webster, K. A., Powell-Coffman, J. A., Tokishita, S., Yamagata, H., Hankeln, T., Burmester, T., Rytkönen, K. T., Nikinmaa, M., Abele, D., Heise, K., Lucassen, M., Fandrey, J., Maxwell, P. H., Påhlman, S., Gorr, T. A.

“…The objective of this symposium at the First International Congress of Respiratory Biology (ICRB) was to enhance communication between comparative biologists…”
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HIF-2α expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia by Nilsson, Helén, Jögi, Annika, Beckman, Siv, Harris, Adrian L., Poellinger, Lorenz, Påhlman, Sven

“…Solid tumors are frequently necrotic and hypoxic due to poor vascularization. Tumor cells adapt to hypoxia by modulating their phenotype. Key players in this…”
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Induced neuroblastoma cell differentiation, associated with transient HES‐1 activity and reduced HASH‐1 expression, is inhibited by Notch1 by Grynfeld, Anna, Påhlman, Sven, Axelson, Håkan

“…Neuroblastoma is a childhood tumor that originates from the sympathetic nervous system. The tumor cells have embryonic features, presumably as a consequence of…”
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HASH-1 and E2-2 Are Expressed in Human Neuroblastoma Cells and Form a Functional Complex by Persson, Paula, Jögi, Annika, Grynfeld, Anna, Påhlman, Sven, Axelson, Håkan

“…The basic helix-loop-helix (bHLH) transcription factor mammalian achaete-scute homolog-1 (MASH-1 in mouse and HASH-1 in human) is essential for proper…”
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Localization of neurotrophins and their high-affinity receptors during human enteric nervous system development by Hoehner, JC, Wester, T, Pahlman, S, Olsen, L

“…BACKGROUND & AIMS: Interactions of neurotrophins with the appropriate trk receptors result in growth and maturational alterations in nervous system cells…”
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A developmental model of neuroblastoma: differentiating stroma-poor tumors' progress along an extra-adrenal chromaffin lineage by Hoehner, J C, Gestblom, C, Hedborg, F, Sandstedt, B, Olsen, L, Påhlman, S

“…The prognosis of children with neuroblastoma (NB) is dependent upon the patient's age at diagnosis, the location of the primary tumor, and histologic tumor…”
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Association of neurotrophin receptor expression and differentiation in human neuroblastoma by Hoehner, JC, Olsen, L, Sandstedt, B, Kaplan, DR, Pahlman, S

“…Interactions of the trk family of tyrosine kinase receptors with neurotrophins result in growth and maturational changes in neuronal cells. The continued…”
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Novel and classical protein kinase C isoforms have different functions in proliferation, survival and differentiation of neuroblastoma cells by Zeidman, Ruth, Pettersson, Linda, Sailaja, P. Ranga, Truedsson, Emma, Fagerström, Sofia, Påhlman, Sven, Larsson, Christer

“…To elucidate the possibility of utilizing protein kinase C (PKC) isoforms as target genes in neuroblastoma therapy, 5 neuroblastoma cell lines and…”
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The angiogenesis inhibitor TNP-470 reduces the growth rate of human neuroblastoma in nude rats by WASSBERG, E, PAHLMAN, S, WESTLIN, J.-E, CHRISTOFFERSON, R

“…A new animal experimental model of human neuroblastoma is described. The model involves xenotransplantation of a poorly differentiated human neuroblastoma cell…”
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Interferon‐γ cooperates with retinoic acid and phorbol ester to induce differentiation and growth inhibition of human neuroblastoma cells by Guzhova, Irina, Hultquist, Anne, Cetinkaya, Cihan, Nilsson, Kenneth, Påhlman, Sven, Larsson, Lars‐Gunnar

“…The prognosis of patients with advanced stages of neuroblastoma with N‐myc amplification remains poor despite escalated therapy, a situation that has called…”
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Spatial association of apoptosis-related gene expression and cellular death in clinical neuroblastoma by HOEHNER, J. C, GESTBLOM, C, OLSEN, L, PAHLMAN, S

“…Several unique features of neuroblastoma (NB), including the capacity for spontaneous regression and maturation to benign pathology, suggest that genes that…”
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The basic helix-loop-helix transcription factor dHAND, a marker gene for the developing human sympathetic nervous system, is expressed in both high- and low-stage neuroblastomas by Gestblom, C, Grynfeld, A, Ora, I, Ortoft, E, Larsson, C, Axelson, H, Sandstedt, B, Cserjesi, P, Olson, E N, Påhlman, S

“…Neuroblastoma is derived from the sympathetic nervous system and might arise as a result of impaired differentiation, retaining the neuroblastic tumor cells in…”
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In vivo spontaneous neuronal to neuroendocrine lineage conversion in a subset of neuroblastomas by Gestblom, C, Hoehner, JC, Hedborg, F, Sandstedt, B, Pahlman, S

“…Neuroblastoma is an embryonal tumor derived from the sympathetic nervous system. Although all neuroblastomas have a neuronal character, a subset of tumors also…”
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Human Achaete-Scute Homologue 1 (HASH-1) Is Downregulated in Differentiating Neuroblastoma Cells by Söderholm, Helena, Örtoft, Eva, Johansson, Irja, Ljungberg, June, Larsson, Christer, Axelson, Håkan, Påhlman, Sven

“…The mammalian achaete-scute homologue,MASH-1,is crucial for early development of the sympathetic nervous system and is transiently expressed in sympathetic…”
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