Search Results - "P, Stemmer"

A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner by Stemmer, Willem P C, Schellenberger, Volker, Wang, Chia-wei, Geething, Nathan C, Spink, Benjamin J, Campbell, Andrew, To, Wayne, Scholle, Michael D, Yin, Yong, Yao, Yi, Bogin, Oren, Cleland, Jeffrey L, Silverman, Joshua

“…Increasing the in vivo residence times of protein therapeutics could decrease their dosing frequencies. We show that genetic fusion of an unstructured…”
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Neighborhoods, Racism, Stress, and Preterm Birth Among African American Women: A Review by C, Giurgescu, D P, Misra, J C, Slaughter-Acey, S L, Gillespie, A L, Nowak, E, Dove-Medows, C G, Engeland, S N, Zenk, T A, Lydic, S, Sealy-Jefferson, J, Ford, S, Drury, P, Stemmer

“…African American women are more likely to experience preterm birth (<37 completed weeks gestation) compared with White women. African American women are also…”
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Mercury intoxication disrupts tonic signaling in B cells, and may promote autoimmunity due to abnormal phosphorylation of STIM-1 and other autoimmunity risk associated phosphoproteins involved in BCR signaling by Carruthers, N.J., Guo, C., Gill, R., Stemmer, P.M., Rosenspire, A.J.

“…Epidemiological studies link exposure to mercury with autoimmune disease. Unfortunately, in spite of considerable effort, no generally accepted mechanistic…”
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DNA shuffling of a family of genes from diverse species accelerates directed evolution by Stemmer, Willem P. C, Crameri, Andreas, Raillard, Sun-Ai, Bermudez, Ericka

“…DNA shuffling is a powerful process for directed evolution, which generates diversity by recombination,, combining useful mutations from individual genes…”
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GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's disease model by Alters, Susan E, McLaughlin, Bryant, Spink, Benjamin, Lachinyan, Tigran, Wang, Chia-wei, Podust, Vladimir, Schellenberger, Volker, Stemmer, Willem P C

“…Glucagon-like peptide 2 (GLP2) is an intestinal growth factor that has been shown to stimulate intestinal growth and reduce disease severity in preclinical…”
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Petroleum coke exposure leads to altered secretome profiles in human lung models by Caruso, J A, Stemmer, P M

“…Petroleum coke (PC) is a coal-like product that is produced during the refinement of crude oil and bituminous sand. Fugitive dust from open storage of PC in…”
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The role of process temperature and rotational speed in the microstructure evolution of Ti-6Al-4V friction surfacing coatings by Fitseva, V., Hanke, S., Santos, J.F. dos, Stemmer, P., Gleising, B.

“…Friction surfacing is a solid state technique for depositing metallic coatings. Coating materials are thermo-mechanically processed at high temperatures during…”
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A novel long-acting human growth hormone fusion protein (VRS-317): enhanced in vivo potency and half-life by Cleland, Jeffrey L, Geething, Nathan C, Moore, Jerome A, Rogers, Brian C, Spink, Benjamin J, Wang, Chai-Wei, Alters, Susan E, Stemmer, Willem P C, Schellenberger, Volker

“…A novel recombinant human growth hormone (rhGH) fusion protein (VRS-317) was designed to minimize receptor-mediated clearance through a reduction in receptor…”
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DNA Shuffling by Random Fragmentation and Reassembly: In vitro Recombination for Molecular Evolution by Stemmer, W P

“…Computer simulations of the evolution of linear sequences have demonstrated the importance of recombination of blocks of sequence rather than point mutagenesis…”
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Rapid evolution of a protein in vitro by DNA shuffling by Stemmer, Willem P. C

“…DNA shuffling is a method for in vitro homologous recombination of pools of selected mutant genes by random fragmentation and polymerase chain reaction (PCR)…”
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Genome shuffling leads to rapid phenotypic improvement in bacteria by del Cardayré, Stephen B, Zhang, Ying-Xin, Perry, Kim, Vinci, Victor A, Powell, Keith, Stemmer, Willem P. C

“…For millennia, selective breeding, on the basis of biparental mating, has led to the successful improvement of plants and animals to meet societal needs. At a…”
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New insights into hard phases of CoCrMo metal-on-metal hip replacements by Liao, Y., Pourzal, R., Stemmer, P., Wimmer, M.A., Jacobs, J.J., Fischer, A., Marks, L.D.

“…The microstructural and mechanical properties of the hard phases in CoCrMo prosthetic alloys in both cast and wrought conditions were examined using…”
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Gcg-XTEN: an improved glucagon capable of preventing hypoglycemia without increasing baseline blood glucose by Geething, Nathan C, To, Wayne, Spink, Benjamin J, Scholle, Michael D, Wang, Chia-wei, Yin, Yong, Yao, Yi, Schellenberger, Volker, Cleland, Jeffrey L, Stemmer, Willem P C, Silverman, Joshua

“…While the majority of current diabetes treatments focus on reducing blood glucose levels, hypoglycemia represents a significant risk associated with insulin…”
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Genome shuffling of Lactobacillus for improved acid tolerance by del Cardayré, Stephen, Gavrilovic, Vesna, Ryan, Chris M, Patnaik, Ranjan, Louie, Susan, Stemmer, Willem P.C, Perry, Kim

“…Fermentation-based bioprocesses rely extensively on strain improvement for commercialization. Whole-cell biocatalysts are commonly limited by low tolerance of…”
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Predicting the emergence of antibiotic resistance by directed evolution and structural analysis by Stevens, Raymond C, Orencia, M. Cecilia, Yoon, Jun S, Ness, Jon E, Stemmer, Willem P. C

“…Directed evolution can be a powerful tool to predict antibiotic resistance. Resistance involves the accumulation of mutations beneficial to the pathogen while…”
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Directed Evolution of a Fucosidase from a Galactosidase by DNA Shuffling and Screening by Zhang, Ji-Hu, Dawes, Glenn, Willem P. C. Stemmer

“…An efficient β -fucosidase was evolved by DNA shuffling from the Escherichia coli lacZ β -galactosidase. Seven rounds of DNA shuffling and colony screening on…”
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Directed evolution of proteins by exon shuffling by Stemmer, Willem P.C, Kolkman, Joost A

“…Evolution of eukaryotes is mediated by sexual recombination of parental genomes. Crossovers occur in random, but homologous, positions at a frequency that…”
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Molecular architecture of the pancreatic zymogen granule-protein copy number determination by Skallos, P, Hubbs, G, Fang, J, Stemmer, P, Jena, B, Chen, X

“…[...]more importantly, whole ZG lysate was used in this study to avoid the need to isolate ZG membrane…”
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Improving the Catalytic Activity of a Thermophilic Enzyme at Low Temperatures by Merz, Astrid, Yee, Muh-ching, Szadkowski, Halina, Pappenberger, Günter, Crameri, Andreas, Stemmer, Willem P. C, Yanofsky, Charles, Kirschner, Kasper

“…Enzymes from thermophilic organisms often are barely active at low temperatures. To obtain a better understanding of this sluggishness, we used DNA shuffling…”
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Effect of interactive metronome training on children with ADHD by Shaffer, R J, Jacokes, L E, Cassily, J F, Greenspan, S I, Tuchman, R F, Stemmer, Jr, P J

“…The purpose of this study was to determine the effects of a specific intervention, the Interactive Metronome, on selected aspects of motor and cognitive skills…”
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