CROHN'S DISEASE AND SECONDARY AMYLOIDOSIS: EARLY COMPLICATION? A CASE REPORT AND REVIEW OF THE LITERATURE

SUMMARY Secondary amyloidosis is a rare but serious complication of inflammatory bowel disease (IBD), generally seen in Crohn's disease. At least 1% of patients with Crohn's disease develop amyloidosis. In the literature, the time lapse between the onset of Crohn's disease and the dia...

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Bibliographic Details
Published in:	Journal of renal care Vol. 35; no. 3; pp. 147 - 150
Main Authors:	Basturk, Taner, Ozagarı, Aysım, Ozturk, Tulım, Kusaslan, Ramazan, Unsal, Abdulkadır
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-09-2009
Subjects:	Adult Amyloidosis - blood Amyloidosis - diagnosis Amyloidosis - etiology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biopsy Colchicine - therapeutic use Crohn Disease - complications Crohn Disease - diagnosis Crohn Disease - drug therapy Crohn's disease Disease Progression Early Diagnosis Humans Hypertension - etiology Hypoalbuminemia - etiology Kidney Failure, Chronic - etiology Kidney Failure, Chronic - therapy Male Mesalamine - therapeutic use Nursing Proteinuria - etiology Rare Diseases Renal Dialysis Renal failure Risk Factors Secondary amyloidosis Time Factors
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Summary:	SUMMARY Secondary amyloidosis is a rare but serious complication of inflammatory bowel disease (IBD), generally seen in Crohn's disease. At least 1% of patients with Crohn's disease develop amyloidosis. In the literature, the time lapse between the onset of Crohn's disease and the diagnosis of amyloidosis has been reported to range from one to 21 years. In most patients, protein‐uria heralded the onset of renal involvement from amyloid and occurred from three to 15 years after Crohn's disease diagnosis. In this case, we estimate secondary amyloidosis occurred before Crohn's disease or early Crohn's disease complication, based on the fact that hypoalbuminaemia and proteinuria was detected approximately one year after the start of gastrointestinal complaints.
Bibliography:	istex:13242D6E18809AD05626A59B6B241C5944FFEDA2 ark:/67375/WNG-WT4M9G91-H ArticleID:JORC106 ObjectType-Case Study-3 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Review-1 ObjectType-Feature-5 ObjectType-Report-2 ObjectType-Article-4 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	1755-6678 1755-6686
DOI:	10.1111/j.1755-6686.2009.00106.x