Immunolabelling of SCF and c-KIT in canine perianal gland tumours

Immunolabelling of SCF and c-KIT in canine perianal gland tumours

c-KIT and its ligand stem cell factor (SCF) play a direct role in the oncogenesis of various cancers by regulating the cell fate. Recent evidence indicates that an increased expression of c-KIT/SCF, driven by hormonal imbalances, is an important step in the development of hormone-dependent cancers....

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Bibliographic Details
Published in:Journal of comparative pathology Vol. 200; pp. 51 - 58
Main Authors: Ipek, Emrah, Epikmen, Erkmen T, Yildirim, Funda, Ozsoy, Sule Y, Tunca, Recai
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-01-2023
Subjects:
Adenoma - veterinary
Anal Gland Neoplasms - pathology
Animals
c-KIT
canine
Carcinoma - veterinary
Dog Diseases - metabolism
Dogs
perianal gland tumour
Proto-Oncogene Proteins c-kit - metabolism
SCF
Stem Cell Factor - metabolism
canine
c-KIT
perianal gland tumour
SCF
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Summary:c-KIT and its ligand stem cell factor (SCF) play a direct role in the oncogenesis of various cancers by regulating the cell fate. Recent evidence indicates that an increased expression of c-KIT/SCF, driven by hormonal imbalances, is an important step in the development of hormone-dependent cancers. We investigated the possible role of the c-KIT/SCF system in the carcinogenesis in 44 perianal gland tumours (16 adenomas, 15 epitheliomas and 13 carcinomas) and 10 normal perianal gland tissues by assessing the percentage and type of cells that expressed c-KIT and SCF as well as the cellular localization of immunoreactivity. No differences in immunolabelling of SCF were found between normal glands and neoplastic cells of any histotype. The highest expression of c-KIT was seen in carcinomas and a positive correlation was found between c-KIT labelling score and mitotic index (R = 0.876; P <0.01). c-KIT labelling patterns in hepatoid cells varied among the tumour histotypes with adenomas having only membranous labelling. Three labelling patterns (membranous only, membranous and cytosolic, and cytosolic only) were seen in the other tumour histotypes. Cytosolic labelling was statistically more frequent in carcinomas than in adenomas (P <0.001). These findings suggest that c-KIT expression and its cellular localization may play a role in the development and progression of perianal gland tumours by influencing cell proliferation.
ISSN:0021-9975
1532-3129
DOI:10.1016/j.jcpa.2022.11.007