Search Results - "Ozoren, Nesrin"

Structural and Dynamics Aspects of ASC Speck Assembly by Sahillioglu, Ali Can, Sumbul, Fidan, Ozoren, Nesrin, Haliloglu, Turkan

“…Activation of the inflammasome is accompanied by rapid formation of a micrometer-sized perinuclear structure called the ASC speck, a platform for caspase-1…”
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NLRC3 protein inhibits inflammation by disrupting NALP3 inflammasome assembly via competition with the adaptor protein ASC for pro-caspase-1 binding by Eren, Elif, Berber, Mesut, Özören, Nesrin

“…Inflammasomes are multiprotein complexes that sense pathogen-associated and danger-associated molecular patterns and induce inflammation in cells. The NALP3…”
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The NLRP3 inflammasome: a new player in neurological diseases by Eren, Elif, Özören, Nesrin

“…Inflammasomes are supramolecular protein complexes implicated in the detection of pathogens or danger-associated molecules and are responsible for mounting the…”
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Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3 by Núñez, Gabriel, Kanneganti, Thirumala-Devi, Özören, Nesrin, Body-Malapel, Mathilde, Amer, Amal, Park, Jong-Hwan, Franchi, Luigi, Whitfield, Joel, Barchet, Winfried, Colonna, Marco, Vandenabeele, Peter, Bertin, John, Coyle, Anthony, Grant, Ethan P, Akira, Shizuo

“…Missense mutations in the CIAS1 gene cause three autoinflammatory disorders: familial cold autoinflammatory syndrome, Muckle-Wells syndrome and neonatal-onset…”
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Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages by Núñez, Gabriel, Franchi, Luigi, Amer, Amal, Body-Malapel, Mathilde, Kanneganti, Thirumala-Devi, Özören, Nesrin, Jagirdar, Rajesh, Inohara, Naohiro, Vandenabeele, Peter, Bertin, John, Coyle, Anthony, Grant, Ethan P

“…Gram-negative bacteria that replicate in the cytosol of mammalian macrophages can activate a signaling pathway leading to caspase-1 cleavage and secretion of…”
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Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf by Amer, Amal, Franchi, Luigi, Kanneganti, Thirumala-Devi, Body-Malapel, Mathilde, Özören, Nesrin, Brady, Graham, Meshinchi, Sasha, Jagirdar, Rajesh, Gewirtz, Andrew, Akira, Shizuo, Núñez, Gabriel

“…Legionella pneumophila is an intracellular bacterium that causes an acute form of pneumonia called Legionnaires' disease. After infection of human macrophages,…”
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NLRP7 plays a functional role in regulating BMP4 signaling during differentiation of patient-derived trophoblasts by Alici-Garipcan, Aybuke, Özçimen, Burcu, Süder, Ilke, Ülker, Volkan, Önder, Tamer T., Özören, Nesrin

“…Complete hydatidiform mole (HM) is a gestational trophoblastic disease resulting in hyperproliferation of trophoblast cells and absence of embryo development…”
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Modulation of mechanosensitive genes during embryonic aortic arch development by Siddiqui, Hummaira Banu, Golcez, Tansu, Çelik, Merve, Sevgin, Börteçine, Çoban, Mervenur, Süder, İlke, Kaya, Özen, Özören, Nesrin, Pekkan, Kerem

“…Early embryonic aortic arches (AA) are a dynamic vascular structures that are in the process of shaping into the great arteries of cardiovascular system…”
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Computational analysis of missense filamin-A variants, including the novel p.Arg484Gln variant of two brothers with periventricular nodular heterotopia by Gerlevik, Umut, Saygı, Ceren, Cangül, Hakan, Kutlu, Aslı, Çaralan, Erdal Fırat, Topçu, Yasemin, Özören, Nesrin, Sezerman, Osman Uğur

“…Periventricular nodular heterotopia (PNH) is a cell migration disorder associated with mutations in Filamin-A (FLNA) gene on chromosome X. Majority of the…”
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Computational analysis of missense filamin-A variants, including the novel p.Arg484Gln variant of two brothers with periventricular nodular heterotopia by Umut Gerlevik, Ceren Saygı, Hakan Cangül, Aslı Kutlu, Erdal Fırat Çaralan, Yasemin Topçu, Nesrin Özören, Osman Uğur Sezerman

“…Background Periventricular nodular heterotopia (PNH) is a cell migration disorder associated with mutations in Filamin-A (FLNA) gene on chromosome X. Majority…”
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Overexpressed NLRC3 Acts as an Anti-Inflammatory Cytosolic Protein by Gültekin, Yetiş, Eren, Elif, Özören, Nesrin

“…The novel nucleotide oligomerization domain (NOD)-like receptor (NLR) with a caspase activation and recruitment domain (CARD) 3 (NLRC3) protein belongs to the…”
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Artificial Loading of ASC Specks with Cytosolic Antigens by Sahillioğlu, Ali Can, Özören, Nesrin

“…Inflammasome complexes form upon interaction of Nod Like Receptor (NLR) proteins with pathogen associated molecular patterns (PAPMS) inside the cytosol…”
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Whole genome sequencing of Turkish genomes reveals functional private alleles and impact of genetic interactions with Europe, Asia and Africa by Alkan, Can, Kavak, Pinar, Somel, Mehmet, Gokcumen, Omer, Ugurlu, Serkan, Saygi, Ceren, Dal, Elif, Bugra, Kuyas, Güngör, Tunga, Sahinalp, S Cenk, Özören, Nesrin, Bekpen, Cemalettin

“…Turkey is a crossroads of major population movements throughout history and has been a hotspot of cultural interactions. Several studies have investigated the…”
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A possible founder mutation in FZD6 gene in a Turkish family with autosomal recessive nail dysplasia by Saygı, Ceren, Alanay, Yasemin, Sezerman, Uğur, Yenenler, Aslı, Özören, Nesrin

“…Autosomal recessive nail dysplasia is characterized by thick and hard nails with a very slow growth on the hands and feet. Mutations in FZD6 gene were found to…”
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Distinct Roles of TLR2 and the Adaptor ASC in IL-1β/IL-18 Secretion in Response to Listeria monocytogenes by Özören, Nesrin, Masumoto, Junya, Franchi, Luigi, Kanneganti, Thirumala-Devi, Body-Malapel, Mathilde, Ertürk, İlkim, Jagirdar, Rajesh, Zhu, Li, Inohara, Naohiro, Bertin, John, Coyle, Anthony, Grant, Ethan P., Núñez, Gabriel

“…Apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC) is an adaptor molecule that has recently been implicated in…”
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Caspase-1: Past and Future of this Major Player in Cell Death and Inflammation by Eren, Elif, Ozoren, Nesrin

“…Inflammation is a major physiological process required for the detection of pathogens and their elimination from an organism. It is triggered by the innate…”
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Application of scanning acoustic microscopy for evaluation of MMP activation in multiple cancer cell lines with a smart probe by Otaş, Hasan Ozan, Uluç, Nasire, Demirkan, İrem, Alkan, Aylin, Yilmazer, Açelya, Yaşa, Seda, Khalafkhany, Davod, Özören, Nesrin, Ünlü, Mehmet Burçin

“…Matrix metalloproteinases (MMPs) play an important role in the evaluation of many cancer types; however, the detection usually presents a challenge. Further…”
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Cell surface Death Receptor signaling in normal and cancer cells by Ozoren, N, El-Deiry, W S

“…The extrinsic cell death pathway is initiated upon ligand–receptor interactions at the cell surface including FAS ligand–FAS/APO1, TNF–TNF receptors, and…”
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Defining Characteristics of Types I and II Apoptotic Cells in Response to TRAIL by Özören, Nesrin, El-Deiry, Wafik S.

“…Type I cells have been defined to be independent of mitochondria for the induction of Fas death receptormediated apoptosis, whereas Type II cells are…”
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Novel NLRP3/cryopyrin mutations and pro-inflammatory cytokine profiles in Behçet's syndrome patients by Yüksel, Şahru, Eren, Elif, Hatemi, Gülen, Sahillioğlu, Ali Can, Gültekin, Yetiş, Demiröz, Duygu, Akdiş, Cezmi, Fresko, İzzet, Özören, Nesrin

“…Behçet's syndrome (BS) is a systemic inflammatory disorder with unknown etiology. Features of both innate and adaptive immunity have been claimed in the…”
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