In vitro cytotoxic effects of Brazilian plant extracts on squamous cell carcinoma of the oral cavity

Squamous cell carcinoma (SCC) is the most prevalent cancer of the oral cavity and the fifth most prevalent of all malignancies in males. Many researchers have attempted to develop new treatments that will improve the prognosis of SCC patients. Over 20% of the world's biodiversity is located wit...

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Bibliographic Details
Published in:	Brazilian oral research Vol. 25; no. 6; pp. 519 - 525
Main Authors:	Ozi, Joana Mattos, Suffredini, Ivana Barbosa, Paciencia, Mateus, Frana, Sergio Alexandre, Dib, Luciano Lauria
Format:	Journal Article
Language:	English
Published:	Brazil Sociedade Brasileira de Pesquisa Odontológica - SBPqO 01-12-2011 Sociedade Brasileira de Pesquisa Odontológica
Subjects:	Analysis of Variance Antineoplastic Agents, Phytogenic - therapeutic use Brazil Carcinoma, Squamous Cell Carcinoma, Squamous Cell - drug therapy Cell Count Cell Culture Techniques Cell Line, Tumor Dentistry DENTISTRY, ORAL SURGERY & MEDICINE Drug Screening Assays, Antitumor - methods Humans Magnoliopsida - chemistry Mouth Neoplasm Mouth Neoplasms - drug therapy Plant Extracts Plant Extracts - chemistry Plant Extracts - therapeutic use Plant Leaves - chemistry Plant Stems - chemistry Plants, Medicinal - chemistry Time Factors Carcinoma, Squamous Cell Plant Extracts Mouth Neoplasm
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Summary:	Squamous cell carcinoma (SCC) is the most prevalent cancer of the oral cavity and the fifth most prevalent of all malignancies in males. Many researchers have attempted to develop new treatments that will improve the prognosis of SCC patients. Over 20% of the world's biodiversity is located within the Brazilian forests, but little is known about the chemical and/or pharmacological potential of these plants. Certain extracts obtained from Amazon and Atlantic Forest plants have previously been shown to have cytotoxic activity against various cancers. The aim of this study was to screen these extracts for cytotoxic activity against oral SCC cells. The extracts were analyzed for activity against the KB-ADL#12 cell line at various concentrations up to a maximum dose of 100 µg/mL. Comparisons with a control group were performed using one-way ANOVA. Significant cytotoxicity was induced by the extracts obtained from the aerial parts of Picrolemma sprucei (Simaroubaceae), from the leaves and stems of Laetia suaveolens (Salicaceae), from the aerial parts of Abarema auriculata (Fabaceae-Mimosoideae) and from the stem of A. auriculata.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1806-8324 1807-3107 1807-3107 1806-8324
DOI:	10.1590/s1806-83242011000600008