Search Results - "Ozgür, Aykut"

Investigation of anticancer activities of STA-9090 (ganetespib) as a second generation HSP90 inhibitor in Saos-2 osteosarcoma cells by Özgür, Aykut

“…Osteosarcoma is common childhood tumour type of the bone. Chemotherapy is the most important step in treatment of osteosarcoma. Despite advanced diagnosis…”
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Molecular mechanism of anticancer effect of heat shock protein 90 inhibitor BIIB021 in human bladder cancer cell line by Asdemir, Aydemir, Özgür, Aykut

“…Bladder cancer is a type of urologic malignancy that exhibits significant morbidity, mortality, and treatment costs. Inhibition of heat shock protein 90…”
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Small molecule heat shock protein 27 inhibitor J2 decreases ovarian cancer cell proliferation via induction of apoptotic pathways by Karademir, Dilay, Özgür, Aykut

“…Heat shock protein 27 (Hsp27) is an important member of the chaperone protein family and its overexpression promotes cancer cell survival. Here, we…”
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The effects of STA-9090 (Ganetespib) and venetoclax (ABT-199) combination on apoptotic pathways in human cervical cancer cells by Karademir, Dilay, Özgür, Aykut

“…Combined chemotherapy is recommended strategy as a first-line treatment method in patients with cervical cancer. Ganetespib (STA-9090) is a second-generation…”
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Combination of navitoclax (Bcl-2 and Bcl-xL inhibitor) and Debio-0932 (Hsp90 inhibitor) suppresses the viability of prostate cancer cells via induction of apoptotic signaling pathway by Asdemir, Aydemir, Özgür, Aykut

“…Prostate cancer is one of the most common cancers in men. Given the diverse nature of prostate cancer and its tendency to respond differently to various…”
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Synthesis and anticancer activity of acyl thioureas bearing pyrazole moiety by Koca, İrfan, Özgür, Aykut, Coşkun, Kübra Açikalin, Tutar, Yusuf

“…In this work novel organic based compounds, acyl thiourea derivatives were synthesized and their anticancer activities were investigated. A new series of acyl…”
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Heat Shock Protein 90 Inhibition in Cancer Drug Discovery: From Chemistry to Futural Clinical Applications by Özgür, Aykut, Tutar, Yusuf

“…Heat shock protein 90 (Hsp90) is an important member of the chaperone protein family and it is involved in stabilization, regulation, and maintenance of…”
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Computational Analysis of Drug Resistance Network in Lung Adenocarcinoma by Kara, Altan, Özgür, Aykut, Tekin, Şaban, Tutar, Yusuf

“…Lung cancer is a significant health problem and accounts for one-third of the deaths worldwide. A great majority of these deaths are caused by Non-Small Cell…”
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Effect of dexpanthenol on cyclophosphamide-induced ovarian toxicity: a histological and molecular study in rats by Ekici, Mehmet, Ateş, Mehmet Burak, Baş-Ekici, Hacer, Özgür, Aykut

“…Does dexpanthenol work as an effective therapeutic agent against cyclophosphamide (CYC)-induced premature ovarian failure (POF) in rats? A total of 28 female…”
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DNA repair pathways and their roles in drug resistance for lung adenocarcinoma by Kara, Altan, Özgür, Aykut, Nalbantoğlu, Sinem, Karadağ, Abdullah

“…Lung cancer is the leading cancer type of death rate. The lung adenocarcinoma subtype is responsible for almost half of the total lung cancer deaths. Despite…”
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Therapeutic Targeting of microRNAs in Cancer: Future Perspectives by Tutar, Lütfi, Tutar, Esen, Özgür, Aykut, Tutar, Yusuf

“…ABSTRACT Preclinical Research The discovery of microRNAs (miRNAs) and their link with cancer has opened a new era in cancer therapeutics. Approximately, 18 −…”
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Efficacy of the greenly synthesized silver, copper, and nickel nanoparticles using Allium tuncelianum extract against Acanthamoeba castellanii by Aykur, Mehmet, Göksen Tosun, Nazan, Kaplan, Özlem, Özgür, Aykut

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Genomic analysis to screen potential genes and mutations in children with non-syndromic early onset severe obesity: a multicentre study in Turkey by Akinci, Aysehan, Kara, Altan, Özgür, Aykut, Turkkahraman, Doga, Aksu, Soner

“…Background Obesity is a complex genetic-based pediatric disorder which triggers life-threatening conditions. Therefore, the understanding the molecular…”
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Microwave-assisted green synthesis of silver nanoparticles using crude extracts of Boletus edulis and Coriolus versicolor: Characterization, anticancer, antimicrobial and wound healing activities by Kaplan, Özlem, Gökşen Tosun, Nazan, Özgür, Aykut, Erden Tayhan, Seçil, Bilgin, Sema, Türkekul, İbrahim, Gökce, İsa

“…The green synthesis of metal nanoparticles has been promising approach in the field of nanomedicine due to its low-cost, non-toxic, biocompatible and…”
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Debio-0932, a second generation oral Hsp90 inhibitor, induces apoptosis in MCF-7 and MDA-MB-231 cell lines by Özgür, Aykut, Kara, Altan, Gökşen Tosun, Nazan, Tekin, Şaban, Gökçe, İsa

“…Heat shock protein 90 (Hsp90) is a key chaperone that is abnormally expressed in cancer cells, and therefore, designing novel compounds to inhibit chaperone…”
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Apoptosis Induced by Tarantula cubensis Crude Venom (Theranekron® D6) in Cancer Cells by Tosun, Nazan Göksen, Kaplan, Özlem, Özgür, Aykut

“…Natural compounds from venomous animals have a big potent in cancer drug discovery. This study aimed to investigate the apoptotic potential of Theranekron D6,…”
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Regulation of oncogenic genes by MicroRNAs and pseudogenes in human lung cancer by Tutar, Yusuf, Özgür, Aykut, Tutar, Esen, Tutar, Lütfi, Pulliero, Alessandra, Izzotti, Alberto

“…Abstract Lung cancer is one of the most common mortal cancer types both for men and women. Several different biomarkers have been analyzed to reveal lung…”
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Biosynthesis and characterization of silver nanoparticles from Tricholoma ustale and Agaricus arvensis extracts and investigation of their antimicrobial, cytotoxic, and apoptotic potentials by Kaplan, Özlem, Gökşen Tosun, Nazan, İmamoğlu, Rizvan, Türkekul, İbrahim, Gökçe, İsa, Özgür, Aykut

“…In this study, silver nanoparticles (AgNPs) were synthesized using Tricholoma ustale and Agaricus arvensis extracts by the microwave-assisted method. The…”
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Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis by Koca, İrfan, Özgür, Aykut, Er, Muhammet, Gümüş, Mehmet, Açikalin Coşkun, Kübra, Tutar, Yusuf

“…Invasive ductal carcinoma is the most common breast malignancies tumors and has tendency to bone metastases. Many oncogenic client proteins involved in…”
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The effect of hesperidin added to quail diets on blood gas, serum biochemistry and Hsp70 in heat stress by Özbilgin, Abdullah, Özgür, Aykut, Başbuğ, Onur

“…Abstract The aim of this study was to determine the effects of flavonoid, which is a product of citrus production, on blood parameters and HSP 70 concentration…”
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