Cytotoxicity and DNA interactions of some platinum(II) complexes with substituted benzimidazole ligands

Cytotoxicity and DNA interactions of some platinum(II) complexes with substituted benzimidazole ligands

In the present study, four Pt(II) complexes with 2-ethyl (1)/or benzyl (2)/or p-chlorobenzyl (3)/or 2-phenoxymethyl (4) benzimidazole carrier ligands were evaluated for their in vitro cytotoxic activities against the human HeLa cervix, oestrogen receptor-positive MCF-7 breast, and oestrogen receptor...

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Bibliographic Details
Published in:Journal of enzyme inhibition and medicinal chemistry Vol. 27; no. 3; p. 413
Main Authors: Ozçelik, Azime Berna, Utku, Semra, Gümüş, Fatma, Keskin, Ayten Çelebi, Açık, Leyla, Yılmaz, Sükran, Ozgüngör, Adeviye
Format: Journal Article
Language:English
Published: England 01-06-2012
Subjects:
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Benzimidazoles - chemistry
Cell Line, Tumor
Cell Proliferation - drug effects
Deoxyribonuclease BamHI - antagonists & inhibitors
Deoxyribonuclease BamHI - metabolism
DNA - drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Ligands
Organoplatinum Compounds - chemical synthesis
Organoplatinum Compounds - chemistry
Organoplatinum Compounds - toxicity
Plasmids
Structure-Activity Relationship
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Summary:In the present study, four Pt(II) complexes with 2-ethyl (1)/or benzyl (2)/or p-chlorobenzyl (3)/or 2-phenoxymethyl (4) benzimidazole carrier ligands were evaluated for their in vitro cytotoxic activities against the human HeLa cervix, oestrogen receptor-positive MCF-7 breast, and oestrogen receptor-negative MDA-MB 231 breast cancer cell lines. The plasmid DNA interactions and inhibition of the BamHI restriction enzyme activities of the complexes were also studied. Complex 3 was found to be more active than carboplatin for all examined cell lines and comparable with cisplatin, except for the HeLa cell line.
ISSN:1475-6374
DOI:10.3109/14756366.2011.594046