Search Results - "Ozer, Bugra"

An experimentally validated approach to automated biological evidence generation in drug discovery using knowledge graphs by Sudhahar, Saatviga, Ozer, Bugra, Chang, Jiakang, Chadwick, Wayne, O’Donovan, Daniel, Campbell, Aoife, Tulip, Emma, Thompson, Neil, Roberts, Ian

“…Explaining predictions for drug repositioning with biological knowledge graphs is a challenging problem. Graph completion methods using symbolic reasoning…”
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An integrative study on the impact of highly differentially methylated genes on expression and cancer etiology by Ozer, Bugra, Sezerman, Ugur

“…DNA methylation is an important epigenetic phenomenon that plays a key role in the regulation of expression. Most of the studies on the topic of methylation's…”
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Hereditary spastic paraplegia with recessive trait caused by mutation in KLC4 gene by Bayrakli, Fatih, Poyrazoglu, Hatice Gamze, Yuksel, Sirin, Yakicier, Cengiz, Erguner, Bekir, Sagiroglu, Mahmut Samil, Yuceturk, Betul, Ozer, Bugra, Doganay, Selim, Tanrikulu, Bahattin, Seker, Askin, Akbulut, Fatih, Ozen, Ali, Per, Huseyin, Kumandas, Sefer, Altuner Torun, Yasemin, Bayri, Yasar, Sakar, Mustafa, Dagcinar, Adnan, Ziyal, Ibrahim

“…We report an association between a new causative gene and spastic paraplegia, which is a genetically heterogeneous disorder. Clinical phenotyping of one…”
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Commonalities and Differences Between Max Weber and Michael Foucault on the Theme of “Rationalization of the Body”(“Bedenin Ussallaşması” Teması Üzerinde Max Weber ve Michael Foucault Arasındaki Yakınsamalar ve Farklılıklar) by Buğra ÖZER

“…The main objective of this paper is to elucidate the very nature of ‘the rationalization of the body’ in regard to the convergence and divergences as…”
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Analysis of the interplay between methylation and expression reveals its potential role in cancer aetiology by Ozer, Bugra, Sezerman, Ugur

“…With ongoing developments in technology, changes in DNA methylation levels have become prevalent to study cancer biology. Previous studies report that DNA…”
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canSAR: update to the cancer translational research and drug discovery knowledgebase by Mitsopoulos, Costas, Di Micco, Patrizio, Fernandez, Eloy Villasclaras, Dolciami, Daniela, Holt, Esty, Mica, Ioan L, Coker, Elizabeth A, Tym, Joseph E, Campbell, James, Che, Ka Hing, Ozer, Bugra, Kannas, Christos, Antolin, Albert A, Workman, Paul, Al-Lazikani, Bissan

“…Abstract canSAR (http://cansar.icr.ac.uk) is the largest, public, freely available, integrative translational research and drug discovery knowledgebase for…”
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Effect of SGLT2 Inhibitors on Fibroblast Activation by Lighthouse, Janet, John, Lauren St, Bill, Alicia, Kiflom-Halldow, Eden, Ozer, Bugra, Henry, Nicole

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Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766) by Chessum, Nicola E. A, Sharp, Swee Y, Caldwell, John J, Pasqua, A. Elisa, Wilding, Birgit, Colombano, Giampiero, Collins, Ian, Ozer, Bugra, Richards, Meirion, Rowlands, Martin, Stubbs, Mark, Burke, Rosemary, McAndrew, P. Craig, Clarke, Paul A, Workman, Paul, Cheeseman, Matthew D, Jones, Keith

“…Demonstrating intracellular protein target engagement is an essential step in the development and progression of new chemical probes and potential small…”
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canSAR: update to the cancer translational research and drug discovery knowledgebase by Coker, Elizabeth A, Mitsopoulos, Costas, Tym, Joesph E, Komianou, Angeliki, Kannas, Christos, Di Micco, Patrizio, Villasclaras Fernandez, Eloy, Ozer, Bugra, Antolin, Albert A, Workman, Paul, Al-Lazikani, Bissan

“…Abstract canSAR (http://cansar.icr.ac.uk) is a public, freely available, integrative translational research and drug discovery knowlegebase. canSAR informs…”
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Privacy preserving processing of genomic data: A survey by Akgün, Mete, Bayrak, A. Osman, Ozer, Bugra, Sağıroğlu, M. Şamil

“…[Display omitted] •We categorized pre-existing problems and corresponding solutions.•We make our classifications in more understandable and convenient way.•We…”
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Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence-Enabled Studies of Acute Phosphoproteomic Changes by Coker, Elizabeth A, Stewart, Adam, Ozer, Bugra, Minchom, Anna, Pickard, Lisa, Ruddle, Ruth, Carreira, Suzanne, Popat, Sanjay, O'Brien, Mary, Raynaud, Florence, de Bono, Johann, Al-Lazikani, Bissan, Banerji, Udai

“…We hypothesize that the study of acute protein perturbation in signal transduction by targeted anticancer drugs can predict drug sensitivity of these agents…”
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Revealing the functions of novel mutations in RAB3GAP1 in Martsolf and Warburg micro syndromes by Koparir, Asuman, Karatas, Omer Faruk, Yilmaz, Seda Salman, Suer, Ilknur, Ozer, Bugra, Yuceturk, Betul, Ozen, Mustafa

“…Purpose: Martsolf (MS) and Warburg micro syndromes (WARBM) are rare autosomal recessive inherited allelic disorders, which share similar clinical features…”
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Native Size-Exclusion Chromatography–Based Mass Spectrometry Reveals New Components of the Early Heat Shock Protein 90 Inhibition Response Among Limited Global Changes by Samant, Rahul S., Batista, Silvia, Larance, Mark, Ozer, Bugra, Milton, Christopher I., Bludau, Isabell, Wu, Estelle, Biggins, Laura, Andrews, Simon, Hervieu, Alexia, Johnston, Harvey E., Al-Lazikhani, Bissan, Lamond, Angus I., Clarke, Paul A., Workman, Paul

“…The molecular chaperone heat shock protein 90 (HSP90) works in concert with co-chaperones to stabilize its client proteins, which include multiple drivers of…”
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GeneCOST: a novel scoring-based prioritization framework for identifying disease causing genes by Ozer, Bugra, Sağıroğlu, Mahmut, Demirci, Hüseyin

“…Due to the big data produced by next-generation sequencing studies, there is an evident need for methods to extract the valuable information gathered from…”
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A novel analysis strategy for integrating methylation and expression data reveals core pathways for thyroid cancer aetiology by Ozer, Bugra, Sezerman, Osman Uğur

“…Recently, a wide range of diseases have been associated with changes in DNA methylation levels, which play a vital role in gene expression regulation. With…”
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Abstract 2976: Confirmation of in-cell target engagement using the proteolysis targeting chimeras (PROTACs) against pirin by Sharp, Swee Y., Chessum, Nicola E., Caldwell, John J., Powers, Marissa V., Pasqua, A Elisa, Wilding, Birgit, Collins, Ian, Ozer, Bugra, Rowlands, Martin, Stubbs, Mark, Burke, Rosemary, Montfort, Rob L. van, Cheeseman, Matthew D., Clarke, Paul A., Workman, Paul, Jones, Keith

“…Abstract We recently reported the identification of the original bisamide lead compound CCT251236 as an inhibitor of the HSF1 stress pathway with a high…”
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Expanding the phenotype of phospholipid remodelling disease due to MBOAT7 gene defect by Yalnızoǧlu, Dilek, Özgül, R. Köksal, Oǧuz, Kader K., Özer, Buǧra, Yücel‐Yılmaz, Didem, Gürbüz, Berrak, Serdaroǧlu, Esra, Erol, İlknur, Topçu, Meral, Dursun, Ali

“…MBOAT7 gene codes O‐acyltransferase domain containing seven proteins which is one of four enzymes involved in remodeling of phosphoinositol phosphate (PIP) in…”
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Transhumanism in The Context of Contemporary Art by OZER, Riza Tan Bugra, NUKTE DINCER, Melike

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Image based integrated attitude determination by Ozer, Y. Bugra, Ozkazanc, Yakup

“…Determination of the satellite attitude is one of the critical functions from the moment of launch to the end of the mission. In this study, it has been shown…”
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Multiple sequence alignment based on structural properties by Ozer, Bugra, Gezici, Gizem, Meydan, Cem, Sezerman, Ugur

“…A multiple sequence alignment (MSA) is a sequence alignment of three or more biological sequences. Main idea behind multiple sequence alignment is to see the…”
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