Search Results - "Ozdian, Tomas"

CFTR Correctors and Antioxidants Partially Normalize Lipid Imbalance but not Abnormal Basal Inflammatory Cytokine Profile in CF Bronchial Epithelial Cells by Veltman, Mieke, De Sanctis, Juan B, Stolarczyk, Marta, Klymiuk, Nikolai, Bähr, Andrea, Brouwer, Rutger W, Oole, Edwin, Shah, Juhi, Ozdian, Tomas, Liao, Jie, Martini, Carolina, Radzioch, Danuta, Hanrahan, John W, Scholte, Bob J

“…A deficiency in cystic fibrosis transmembrane conductance regulator (CFTR) function in CF leads to chronic lung disease. CF is associated with abnormalities in…”
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Treatment With LAU-7b Complements CFTR Modulator Therapy by Improving Lung Physiology and Normalizing Lipid Imbalance Associated With CF Lung Disease by Centorame, Amanda, Dumut, Daciana Catalina, Youssef, Mina, Ondra, Martin, Kianicka, Irenej, Shah, Juhi, Paun, Radu Alexandru, Ozdian, Tomas, Hanrahan, John W, Gusev, Ekaterina, Petrof, Basil, Hajduch, Marian, Pislariu, Radu, De Sanctis, Juan Bautista, Radzioch, Danuta

“…Cystic fibrosis (CF) is the most common autosomal recessive genetic disease in Caucasians, affecting more than 100,000 individuals worldwide. It is caused by…”
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The dual role of asporin in breast cancer progression by Simkova, Dana, Kharaishvili, Gvantsa, Korinkova, Gabriela, Ozdian, Tomas, Suchánková-Kleplová, Tereza, Soukup, Tomas, Krupka, Michal, Galandakova, Adela, Dzubak, Petr, Janikova, Maria, Navratil, Jiri, Kahounova, Zuzana, Soucek, Karel, Bouchal, Jan

“…Asporin has been reported as a tumor suppressor in breast cancer, while asporin-activated invasion has been described in gastric cancer. According to our in…”
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Affinity-based methods in drug-target discovery by Rylova, Gabriela, Ozdian, Tomas, Varanasi, Lakshman, Soural, Miroslav, Hlavac, Jan, Holub, Dusan, Dzubak, Petr, Hajduch, Marian

“…Target discovery using the molecular approach, as opposed to the more traditional systems approach requires the study of the cellular or biological process…”
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Identification of N-glycosylation in prolyl endoprotease from Aspergillus niger and evaluation of the enzyme for its possible application in proteomics by Šebela, Marek, Řehulka, Pavel, Kábrt, Jaromír, Řehulková, Helena, Oždian, Tomáš, Raus, Martin, Franc, Vojtěch, Chmelík, Josef

“…An acidic prolyl endoprotease from Aspergillus niger was isolated from the commercial product Brewers Clarex[trade mark sign] to evaluate its possible…”
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Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4 by Skrott, Zdenek, Mistrik, Martin, Andersen, Klaus Kaae, Friis, Søren, Majera, Dusana, Gursky, Jan, Ozdian, Tomas, Bartkova, Jirina, Turi, Zsofia, Moudry, Pavel, Kraus, Marianne, Michalova, Martina, Vaclavkova, Jana, Dzubak, Petr, Vrobel, Ivo, Pouckova, Pavla, Sedlacek, Jindrich, Miklovicova, Andrea, Kutt, Anne, Li, Jing, Mattova, Jana, Driessen, Christoph, Dou, Q. Ping, Olsen, Jørgen, Hajduch, Marian, Cvek, Boris, Deshaies, Raymond J., Bartek, Jiri

“…Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need…”
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Proteomic profiling reveals DNA damage, nucleolar and ribosomal stress are the main responses to oxaliplatin treatment in cancer cells by Ozdian, Tomas, Holub, Dusan, Maceckova, Zuzana, Varanasi, Lakshman, Rylova, Gabriela, Rehulka, Jiri, Vaclavkova, Jana, Slavik, Hanus, Moudry, Pavel, Znojek, Pawel, Stankova, Jarmila, de Sanctis, Juan Bautista, Hajduch, Marian, Dzubak, Petr

“…Oxaliplatin is widely used to treat colorectal cancer in both palliative and adjuvant settings. It is also being tested for use in treating hematological,…”
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Abstract LB-264: Alcohol-aversion drug disulfiram targets cancer via p97 segregase adaptor NPL4 by Mistrik, Martin, Skrott, Zdenek, Hajduch, Marian, Friis, Søren, Dzubak, Petr, Gursky, Jan, Majera, Dusana, Ozdian, Tomas, Vaclavkova, Jana, Michalova, Martina, Pouckova, Pavla, Cvek, Boris, Andersen, Klaus Kaae, Bartek, Jiři

“…Abstract Cancer incidence is rising and this global challenge is further exacerbated by resistance of advanced tumors to standard-of-care and emerging…”
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Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7‑Deazapurine Ribonucleosides by Tichý, Michal, Smoleń, Sabina, Tloušt’ová, Eva, Pohl, Radek, Oždian, Tomáš, Hejtmánková, Klára, Lišková, Barbora, Gurská, Soňa, Džubák, Petr, Hajdúch, Marián, Hocek, Michal

“…Two isomeric series of new thieno-fused 7-deazapurine ribonucleosides (derived from 4-substituted thieno­[2′,3′:4,5]­pyrrolo­[2,3-d]­pyrimidines and…”
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Alcohol-abuse drug disulfiram targets cancer via p97 segregase adapter NPL4 by Skrott, Zdenek, Mistrik, Martin, Andersen, Klaus Kaae, Friis, Søren, Majera, Dusana, Gursky, Jan, Ozdian, Tomas, Bartkova, Jirina, Turi, Zsofia, Moudry, Pavel, Kraus, Marianne, Michalova, Martina, Vaclavkova, Jana, Dzubak, Petr, Vrobel, Ivo, Pouckova, Pavla, Sedlacek, Jindrich, Miklovicova, Andrea, Kutt, Anne, Li, Jing, Mattova, Jana, Driessen, Christoph, Dou, Q. Ping, Olsen, Jørgen, Hajduch, Marian, Cvek, Boris, Deshaies, Raymond J., Bartek, Jiri

“…Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to such unmet…”
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Abstract 4652: Proteomic profiling of platinum based anticancer drugs by Dzubak, Petr, Ozdian, Tomas, Holub, Dusan, Rylova, Gabriela, Rehulka, Jiri, kollareddy, Madhusudhan, Mlcuchova, Daniela, Hajduch, Marian

“…Abstract Carboplatin, cisplatin and oxaliplatin are structurally similar anticancer drugs and their mechanism of action is permanent coordination to DNA and…”
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Proteome Mapping of Cervical Mucus and Its Potential as a Source of Biomarkers in Female Tract Disorders by Oždian, Tomáš, Vodička, Jan, Dostál, Jiří, Holub, Dušan, Václavková, Jana, Ješeta, Michal, Hamerníková, Barbora, Kouřilová, Pavla, Malchar, Ondřej, Dvořák, Vladimír, Hejtmánek, Pavel, Sobková, Kateřina, Ventruba, Pavel, Pilka, Radovan, Džubák, Petr, Hajdúch, Marián

“…Cervical mucus (CM) is a viscous fluid that is produced by the cervical glands and functions as a uterine cervix plug. Its viscosity decreases during…”
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Abstract 4624: Molecular target identification of quinolinone based anticancer compounds by Rylova, Gabriela, Dzubak, Petr, Janostakova, Anna, Frydrych, Ivo, Konecny, Petr, Holub, Dusan, Ozdian, Tomas, Dolezal, Dalibor, Soural, Miroslav, Hlavac, Jan, Hajduch, Marian

“…Abstract Quinolinones, compounds derived from quinolone antibiotics, are well known for their antibacterial, antiprotozoal, cytotoxic and immunosuppressive…”
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Abstract 2641: Diversity of anticancer mechanisms of action of tritepenoids derived from betulinic acid by Dzubak, Petr, Rehulka, Jiri, Holub, Dusan, Ozdian, Tomas, Janostakova, Anna, Sarek, Jan, Vlk, Martin, Hajduch, Marian

“…Abstract Betulinic acid and its derivatives are cytotoxic compounds with the specific effect to the tumor cells. In our betulinic acid derivative chemical…”
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Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins by Ješeta, Michal, Pospíšilová, Anna, Mekiňová, Lenka, Franzová, Kateřina, Ventruba, Pavel, Lousová, Eva, Kempisty, Bartosz, Oždian, Tomáš, Žáková, Jana, Crha, Igor

“…The compounds of seminal plasma have great potential as biomarkers of male fertility and can be used as a diagnostic tool for types of azoospermia. Azoospermia…”
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Abstract 4748: Molecular targets of quinolinone derivatives with anticancer activity by Rylova, Gabriela, Dzubak, Petr, Janostakova, Anna, Frydrych, Ivo, Konecny, Petr, Holub, Dusan, Ozdian, Tomas, Dolezal, Dalibor, Soural, Miroslav, Hlavac, Jan, Hajduch, Marian

“…Abstract Currently, we are testing chemical libraries of quinolinone derivatives, compounds with high selective cytotoxic activity. These compounds, derived…”
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Directed Solid-Phase Synthesis of Trisubstituted Imidazo[4,5‑c]pyridines and Imidazo[4,5‑b]pyridines by Lemrová, Barbora, Smyslová, Petra, Popa, Igor, Oždian, Tomáš, Zajdel, Pawel, Soural, Miroslav

“…An efficient method is described for the solid-supported synthesis of imidazo­[4,5‑b]pyridines and imidazo­[4,5‑c]pyridines from 2,4-dichloro-3-nitro­pyridine…”
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Dr Jekyll and Mr Hyde: a strange case of 5-ethynyl-2′-deoxyuridine and 5-ethynyl-2′-deoxycytidine by Ligasová, Anna, Liboska, Radek, Friedecký, David, Mičová, Kateřina, Adam, Tomáš, Oždian, Tomáš, Rosenberg, Ivan, Koberna, Karel

“…5-Ethynyl-2′-deoxyuridine (EdU) and 5-ethynyl-2′-deoxycytidine (EdC) are mainly used as markers of cellular replicational activity. Although EdU is employed as…”
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Abstract 455: Cellular response to oxaliplatin treatment shows altered DNA damage, nucleolar and ribosomal stresses as main altered pathways by Oždian, Tomáš, Holub, Dušan, Macečková, Zuzana, Varanasi, Lakshman, Rylova, Gabriela, Rehulka, Jiří, Vaclavkova, Jana, Slavík, Hanuš, Moudry, Pavel, Znojek, Pawel, Stanková, Jarmila, Sanctis, Juan Bautista de, Hajduch, Marian, Džubák, Petr

“…Abstract Oxaliplatin is a platinum-based drug playing a critical role in the treatment of colorectal carcinoma and various Hodgkin and non-Hodgkin lymphomas…”
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Tissue expression analysis of cervical mucus proteome by Vodička, Jan, Dostál, Jiří, Holub, Dušan, Pilka, Radovan, Džubák, Petr, Hajdůch, Marián, Oždian, Tomáš

“…Cervical mucus is a viscous fluid functioning as a cervix plug. Products of the endometrial and cervical glands can be detected in the cervical mucus. Cervical…”
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