Search Results - "Ozcan, Umut"

Visco-hyperelastic material modeling using nested linkage mechanisms by Umut Ozcan, M, Yilmaz, Cetin, Sonmez, Fazil O.

“…•A mechanism-based model is developed to simulate visco-hyperelastic material response.•Material nonlinearity is simulated by geometric nonlinearity of the…”
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Potential for therapeutic manipulation of the UPR in disease by Park, Sang Won, Ozcan, Umut

“…Increased endoplasmic reticulum (ER) stress and the activated unfolded protein response (UPR) signaling associated with it play key roles in physiological…”
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IL1R1 is required for celastrol’s leptin-sensitization and antiobesity effects by Feng, Xudong, Guan, Dongxian, Auen, Thomas, Choi, Jae Won, Salazar Hernández, Mario Andrés, Lee, Jaemin, Chun, Hyonho, Faruk, Farhana, Kaplun, Esther, Herbert, Zachary, Copps, Kyle D., Ozcan, Umut

“…Celastrol, a pentacyclic triterpene, is the most potent antiobesity agent that has been reported thus far 1 . The mechanism of celastrol’s leptin-sensitizing…”
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Sarco(endo)plasmic reticulum Ca²⁺-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity by Park, Sang Won, Zhou, Yingjiang, Lee, Jaemin, Lee, Justin, Ozcan, Umut, Karin, Michael

“…Increased endoplasmic reticulum (ER) stress is one of the central mechanisms that lead to dysregulated metabolic homeostasis in obesity. It is thus crucial to…”
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Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance by Ozcan, Lale, Ergin, Ayse Seda, Lu, Allen, Chung, Jason, Sarkar, Sumit, Nie, Duyu, Myers, Martin G., Ozcan, Umut

“…Leptin has not evolved as a therapeutic modality for the treatment of obesity due to the prevalence of leptin resistance in a majority of the obese population…”
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Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis by Ozcan, Umut, Ozcan, Lale, Yilmaz, Erkan, Düvel, Katrin, Sahin, Mustafa, Manning, Brendan D., Hotamisligil, Gökhan S.

“…Mammalian target of rapamycin, mTOR, is a major sensor of nutrient and energy availability in the cell and regulates a variety of cellular processes, including…”
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Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction by Ozcan, Umut, Zhou, Yingjiang, Lee, Justin, Reno, Candace M, Sun, Cheng, Park, Sang Won, Chung, Jason, Lee, Jaemin, Fisher, Simon J, White, Morris F, Biddinger, Sudha B

“…Insulin dials down endogenous hepatic glucose production after a meal by deactivating the transcription factor FoxO1. In a mouse model of insulin resistance,…”
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PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism by Lee, Jaemin, Salazar Hernández, Mario Andrés, Auen, Thomas, Mucka, Patrick, Lee, Justin, Ozcan, Umut

“…Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) promotes hepatic gluconeogenesis by activating HNF4α and FoxO1. PGC-1α expression…”
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Characterization of frequency-dependent material properties of human liver and its pathologies using an impact hammer by Umut Ozcan, M., Ocal, Sina, Basdogan, Cagatay, Dogusoy, Gulen, Tokat, Yaman

“…[Display omitted] ► Frequency-dependent dynamic material properties of human liver and pathologies are characterized by an impact hammer. ► The results of the…”
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Unfolded protein response signaling and metabolic diseases by Lee, Jaemin, Ozcan, Umut

“…The endoplasmic reticulum (ER) is a central organelle for protein biosynthesis, folding, and traffic. Perturbations in ER homeostasis create a condition termed…”
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Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes by Özcan, Umut, Yilmaz, Erkan, Özcan, Lale, Furuhashi, Masato, Vaillancourt, Eric, Smith, Ross O, Görgün, Cem Z, Hotamisligil, Gökhan S

“…Endoplasmic reticulum (ER) stress is a key link between obesity, insulin resistance, and type 2 diabetes. Here, we provide evidence that this mechanistic link…”
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Targeted Elimination of Peroxisome Proliferator-Activated Receptor γ in β Cells Leads to Abnormalities in Islet Mass without Compromising Glucose Homeostasis by Rosen, Evan D., Kulkarni, Rohit N., Sarraf, Pasha, Ozcan, Umut, Okada, Terumasa, Hsu, Chung-Hsin, Eisenman, Daniel, Magnuson, Mark A., Gonzalez, Frank J., Kahn, C. Ronald, Spiegelman, Bruce M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Melanin Concentrating Hormone Is a Novel Regulator of Islet Function and Growth by PISSIOS, Pavlos, OZCAN, Umut, KURPAD, Amarnath J, KENNEDY, Robert T, MARATOS-FLIER, Eleftheria, KULKARNI, Rohit N, KOKKOTOU, Efi, OKADA, Terumasa, CHONG WEE LIEW, SIMING LIU, PETERS, Jennifer N, DAHLGREN, Gabriella, KARAMCHANDANI, Jason, KUDVA, Yogish C

“…Melanin Concentrating Hormone Is a Novel Regulator of Islet Function and Growth Pavlos Pissios 1 , Umut Ozcan 2 , Efi Kokkotou 3 , Terumasa Okada 2 , Chong Wee…”
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Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes by Özcan, Umut, Cao, Qiong, Yilmaz, Erkan, Lee, Ann-Hwee, Iwakoshi, Neal N., Özdelen, Esra, Tuncman, Gürol, Görgün, Cem, Glimcher, Laurie H., Hotamisligil, Gökhan S.

“…Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and mouse models, we show…”
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Mitofusins: Mighty Regulators of Metabolism by Ozcan, Umut

“…Mitochondria are central regulators of cellular metabolism but how their function in a subset of cells affects whole-body energy balance is less understood…”
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Treatment of Obesity with Celastrol by Liu, Junli, Lee, Jaemin, Salazar Hernandez, Mario Andres, Mazitschek, Ralph, Ozcan, Umut

“…Despite all modern advances in medicine, an effective drug treatment of obesity has not been found yet. Discovery of leptin two decades ago created hopes for…”
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Effect of preservation period on the viscoelastic material properties of soft tissues with implications for liver transplantation by Ocal, Sina, Ozcan, M Umut, Basdogan, Ipek, Basdogan, Cagatay

“…The liver harvested from a donor must be preserved and transported to a suitable recipient immediately for a successful liver transplantation. In this process,…”
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Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice by Lee, Jaemin, Liu, Junli, Feng, Xudong, Salazar Hernández, Mario Andrés, Mucka, Patrick, Ibi, Dorina, Choi, Jae Won, Ozcan, Umut

“…Withaferin A is a naturally occurring compound that has potent antidiabetic and anti-obesity properties in mice. The increasing global prevalence of obesity…”
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Mom’s Milk Molds Neural Wiring for Metabolism by Cakir, Isin, Ozcan, Umut

“…Vogt et al. demonstrate that, in mice, maternal high-fat feeding during lactation is sufficient to program the offspring for impaired energy and glucose…”
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The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation by Ueki, Kohjiro, Ozcan, Umut, Park, Sang Won, Zhou, Yingjiang, Lee, Justin, Lu, Allen, Sun, Cheng, Chung, Jason

“…Insulin can signal through phosphotidylinositol 3-kinase (PI3K) to increase cellular growth, which often results in increased protein translation and stress of…”
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