Search Results - "Ozawa, Akihiko"

Chemogenetics drives paradigm change in the investigation of behavioral circuits and neural mechanisms underlying drug action by Ozawa, Akihiko, Arakawa, Hiroyuki

“…•A next-step advent of psychopharmacology will be precipitated by chemogenetics.•Chemogenetics obtains a better spatiotemporal control of neural circuits than…”
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NOP-Related Mechanisms in Pain and Analgesia by Toll, Lawrence, Ozawa, Akihiko, Cippitelli, Andrea

“…Since the discovery of the NOP receptor and N/OFQ as the endogenous ligand, evidence has appeared demonstrating the involvement of this receptor system in…”
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Analysis of the distribution of spinal NOP receptors in a chronic pain model using NOP‐eGFP knock‐in mice by Ozawa, Akihiko, Brunori, Gloria, Cippitelli, Andrea, Toll, Nicholas, Schoch, Jennifer, Kieffer, Brigitte L, Toll, Lawrence

“…Background and Purpose The nociceptin/orphanin FQ opioid peptide (NOP) receptor system plays a significant role in the regulation of pain. This system…”
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Managing Weather Risks: The Case of J. League Soccer Teams in Japan by Ito, Haruyoshi, Ai, Jing, Ozawa, Akihiko

“…Weather-related risks present significant concerns for businesses worldwide. This article studies the impact weather conditions have on the financial…”
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Genome-wide biochemical analysis of Arabidopsis protein phosphatase using a wheat cell-free system by Takahashi, Hirotaka, Ozawa, Akihiko, Nemoto, Keiichirou, Nozawa, Akira, Seki, Motoaki, Shinozaki, Kazuo, Takeda, Hiroyuki, Endo, Yaeta, Sawasaki, Tatsuya

“…► We analyzed the activity of 82 recombinant Arabidopsis PPases with Mg2+ or Mn2+ dependency. ► Twenty-two Ser/Thr and one Tyr-PPase activities were…”
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Dynamic Modulation of Prohormone Convertase 2 (PC2)-mediated Precursor Processing by 7B2 Protein by Helwig, Michael, Lee, Sang-Nam, Hwang, Jae Ryoung, Ozawa, Akihiko, Medrano, Juan F., Lindberg, Iris

“…The small neuroendocrine protein 7B2 is required for the production of active prohormone convertase 2 (PC2), an enzyme involved in the synthesis of peptide…”
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Enzymatic characterization of a human acyltransferase activity by Ozawa, Akihiko, Speaker, 3rd, Richard B, Lindberg, Iris

“…Non-histone protein acylation is increasingly recognized as an important posttranslational modification, but little is known as to the biochemical properties…”
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Synthetic small-molecule prohormone convertase 2 inhibitors by Kowalska, Dorota, Liu, Jin, Appel, Jon R, Ozawa, Akihiko, Nefzi, Adel, Mackin, Robert B, Houghten, Richard A, Lindberg, Iris

“…The proprotein convertases are believed to be responsible for the proteolytic maturation of a large number of peptide hormone precursors. Although potent furin…”
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The NOP Receptor System in Neurological and Psychiatric Disorders: Discrepancies, Peculiarities and Clinical Progress in Developing Targeted Therapies by Toll, Lawrence, Cippitelli, Andrea, Ozawa, Akihiko

“…The nociceptin opioid peptide (NOP) receptor and its endogenous ligand nociceptin/orphanin FQ (N/OFQ) are the fourth members of the opioid receptor and opioid…”
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new class of enzyme acting on damaged ribosomes: ribosomal RNA apurinic site specific lyase found in wheat germ by Ogasawara, T, Sawasaki, T, Morishita, R, Ozawa, A, Madin, K, Endo, Y

“…A new enzyme, which we named ribosomal RNA apurinic site specific lyase (RALyase), is described. The protein was found in wheat embryos and has a molecular…”
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Functional and anatomical analyses of active spinal circuits in a mouse model of chronic pain by Targowska-Duda, Katarzyna M, Peters, Darian, Marcus, Jason L, Zribi, Gilles, Toll, Lawrence, Ozawa, Akihiko

“…Decades of efforts in elucidating pain mechanisms, including pharmacological, neuroanatomical, and physiological studies have provided insights into how…”
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OsRALyase1, a putative F-box protein identified in rice, Oryza sativa, with enzyme activity identical to that of wheat RALyase by Ito, Y. (National Food Research Inst., Tsukuba, Ibaraki (Japan)), Ozawa, A, Sawasaki, T, Endo, Y, Ochi, K, Tozawa, Y

“…A rice gene, OsRALyase1, encoding a product similar to wheat ribosomal RNA apurinic site specific lyase (RALyase), was isolated and expressed in vitro. An open…”
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The influence of neuropathic pain on nAChR plasticity and behavioral responses to nicotine in rats by Brunori, Gloria, Schoch, Jennifer, Mercatelli, Daniela, Ozawa, Akihiko, Toll, Lawrence, Cippitelli, Andrea

“…Tobacco smoking is particularly evident in individuals experiencing chronic pain. This complex relationship is poorly understood at both molecular and…”
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Influence of neuropathic pain on nicotinic acetylcholine receptor plasticity and behavioral responses to nicotine in rats by Brunori, Gloria, Schoch, Jennifer, Mercatelli, Daniela, Ozawa, Akihiko, Toll, Lawrence, Cippitelli, Andrea

“…Tobacco smoking is particularly evident in individuals experiencing chronic pain. This complex relationship is poorly understood at both molecular and…”
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Identification of 5,6-dihydroimidazo[2,1-b]thiazoles as a new class of antimicrobial agents by Li, Yangmei, Bionda, Nina, Fleeman, Renee, Wang, Hongjie, Ozawa, Akihiko, Houghten, Richard A., Shaw, Lindsey

“…[Display omitted] In an effort to develop novel antimicrobial agents against drug-resistant bacterial infections, 5,6-dihydroimidazo[2,1-b]thiazole compounds…”
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Processing of Proaugurin Is Required to Suppress Proliferation of Tumor Cell Lines by Ozawa, Akihiko, Lick, Adam N, Lindberg, Iris

“…Cleavage of proaugurin is required for suppression of tumor cell proliferation. Augurin is a secretory molecule produced in pituitary, thyroid, and esophagus…”
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NOP receptor agonist attenuates nitroglycerin-induced migraine-like symptoms in mice by Targowska-Duda, Katarzyna M., Ozawa, Akihiko, Bertels, Zachariah, Cippitelli, Andrea, Marcus, Jason L., Mielke-Maday, Hanna K., Zribi, Gilles, Rainey, Amanda N., Kieffer, Brigitte L., Pradhan, Amynah A., Toll, Lawrence

“…Migraine is an extraordinarily prevalent and disabling headache disorder that affects one billion people worldwide. Throbbing pain is one of several migraine…”
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Knock-In Mice with NOP-eGFP Receptors Identify Receptor Cellular and Regional Localization by Ozawa, Akihiko, Brunori, Gloria, Mercatelli, Daniela, Wu, Jinhua, Cippitelli, Andrea, Zou, Bende, Xie, Xinmin Simon, Williams, Melissa, Zaveri, Nurulain T, Low, Sarah, Scherrer, Grégory, Kieffer, Brigitte L, Toll, Lawrence

“…The nociceptin/orphanin FQ (NOP) receptor, the fourth member of the opioid receptor family, is involved in many processes common to the opioid receptors…”
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Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception by Toll, Lawrence, Khroyan, Taline V., Sonmez, Kemal, Ozawa, Akihiko, Lindberg, Iris, McLaughlin, Jay P., Eans, Shainnel O., Shahienand, Amir A., Kapusta, Daniel R.

“…ABSTRACT Computational methods have led two groups to predict the endogenous presence of a highly conserved, amidated, 14‐aa neuropeptide called either spexin…”
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Highly Selective and Potent α4β2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats by Wu, Jinhua, Cippitelli, Andrea, Zhang, Yaohong, Debevec, Ginamarie, Schoch, Jennifer, Ozawa, Akihiko, Yu, Yongping, Liu, Huan, Chen, Wenteng, Houghten, Richard A, Welmaker, Gregory S, Giulianotti, Marc A, Toll, Lawrence

“…The α4β2 nAChR is the most predominant subtype in the brain and is a well-known culprit for nicotine addiction. Previously we presented a series of α4β2 nAChR…”
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