Search Results - "Ozark, Patrick A."

Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy by Liang, Kaiwei, Smith, Edwin R., Aoi, Yuki, Stoltz, Kristen L., Katagi, Hiroaki, Woodfin, Ashley R., Rendleman, Emily J., Marshall, Stacy A., Murray, David C., Wang, Lu, Ozark, Patrick A., Mishra, Rama K., Hashizume, Rintaro, Schiltz, Gary E., Shilatifard, Ali

“…The super elongation complex (SEC) is required for robust and productive transcription through release of RNA polymerase II (Pol II) with its P-TEFb module and…”
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Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy by Wang, Lu, Zhao, Zibo, Ozark, Patrick A., Fantini, Damiano, Marshall, Stacy A., Rendleman, Emily J., Cozzolino, Kira A., Louis, Nundia, He, Xingyao, Morgan, Marc A., Takahashi, Yoh-hei, Collings, Clayton K., Smith, Edwin R., Ntziachristos, Panagiotis, Savas, Jeffrey N., Zou, Lihua, Hashizume, Rintaro, Meeks, Joshua J., Shilatifard, Ali

“…The lysine methyltransferase KMT2C (also known as MLL3), a subunit of the COMPASS complex, implements monomethylation of Lys4 on histone H3 (H3K4) at gene…”
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PAF1 regulation of promoter-proximal pause release via enhancer activation by Chen, Fei Xavier, Xie, Peng, Collings, Clayton K., Cao, Kaixiang, Aoi, Yuki, Marshall, Stacy A., Rendleman, Emily J., Ugarenko, Michal, Ozark, Patrick A., Zhang, Anda, Shiekhattar, Ramin, Smith, Edwin R., Zhang, Michael Q., Shilatifard, Ali

“…Gene expression in metazoans is regulated by RNA polymerase II (Pol II) promoter-proximal pausing and its release. Previously,we showed that Pol II–associated…”
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Histone H3K4 methylation-dependent and -independent functions of Set1A/COMPASS in embryonic stem cell self-renewal and differentiation by Sze, Christie C, Cao, Kaixiang, Collings, Clayton K, Marshall, Stacy A, Rendleman, Emily J, Ozark, Patrick A, Chen, Fei Xavier, Morgan, Marc A, Wang, Lu, Shilatifard, Ali

“…Of the six members of the COMPASS (complex of proteins associated with Set1) family of histone H3 Lys4 (H3K4) methyltransferases identified in mammals, Set1A…”
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High-fat high-sugar diet induces polycystic ovary syndrome in a rodent model by Roberts, Jacob S, Perets, Ron A, Sarfert, Kathryn S, Bowman, John J, Ozark, Patrick A, Whitworth, Gregg B, Blythe, Sarah N, Toporikova, Natalia

“…Obesity has been linked with a host of metabolic and reproductive disorders including polycystic ovary syndrome (PCOS). While a clear association exists…”
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TET2 coactivates gene expression through demethylation of enhancers by Wang, Lu, Ozark, Patrick A, Smith, Edwin R, Zhao, Zibo, Marshall, Stacy A, Rendleman, Emily J, Piunti, Andrea, Ryan, Caila, Whelan, Anna L, Helmin, Kathryn A, Morgan, Marc Alard, Zou, Lihua, Singer, Benjamin D, Shilatifard, Ali

“…The tet methylcytosine dioxygenase 2 (TET2) enzyme catalyzes the conversion of the modified DNA base 5-methylcytosine to 5-hydroxymethylcytosine. TET2 is…”
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Coordinated regulation of cellular identity-associated H3K4me3 breadth by the COMPASS family by Sze, Christie C, Ozark, Patrick A, Cao, Kaixiang, Ugarenko, Michal, Das, Siddhartha, Wang, Lu, Marshall, Stacy A, Rendleman, Emily J, Ryan, Caila A, Zha, Didi, Douillet, Delphine, Chen, Fei Xavier, Shilatifard, Ali

“…Set1A and Set1B, two members of the COMPASS family of methyltransferases that methylate the histone H3 lysine 4 (H3K4) residue, have been accredited as primary…”
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An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cells by Cao, Kaixiang, Collings, Clayton K, Morgan, Marc A, Marshall, Stacy A, Rendleman, Emily J, Ozark, Patrick A, Smith, Edwin R, Shilatifard, Ali

“…Chromatin regulators control cellular differentiation by orchestrating dynamic developmental gene expression programs, and hence, malfunctions in the…”
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DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation by Cao, Kaixiang, Ugarenko, Michal, Ozark, Patrick A., Wang, Juan, Marshall, Stacy A., Rendleman, Emily J., Liang, Kaiwei, Wang, Lu, Zou, Lihua, Smith, Edwin R., Yue, Feng, Shilatifard, Ali

“…Actively transcribed genes in mammals are decorated by H3K79 methylation, which is correlated with transcription levels and is catalyzed by the histone…”
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A small UTX stabilization domain of Trr is conserved within mammalian MLL3-4/COMPASS and is sufficient to rescue loss of viability in null animals by Rickels, Ryan, Wang, Lu, Iwanaszko, Marta, Ozark, Patrick A, Morgan, Marc A, Piunti, Andrea, Khalatyan, Natalia, Soliman, Shimaa H A, Rendleman, Emily J, Savas, Jeffrey N, Smith, Edwin R, Shilatifard, Ali

“…Catalytic-inactivating mutations within the enhancer H3K4 mono-methyltransferase Trr and its mammalian homologs, MLL3/4, cause only minor changes in gene…”
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IFN-γ-inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5 by Saleiro, Diana, Blyth, Gavin T, Kosciuczuk, Ewa M, Ozark, Patrick A, Majchrzak-Kita, Beata, Arslan, Ahmet D, Fischietti, Mariafausta, Reddy, Neha K, Horvath, Curt M, Davis, Roger J, Fish, Eleanor N, Platanias, Leonidas C

“…It is well established that activation of the transcription factor signal transducer and activator of transcription 1 (STAT1) is required for the interferon-γ…”
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Effects of Diet‐induced Obesity and Estrogen on the Female Rat Fecal Microbiome by Ozark, Patrick A., Blythe, Sarah N., Toporikova, Natalia, Whitworth, Gregg B.

“…Abstract only…”
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PDTM-39. HISTONE H3 MUTATION EFFECTS ON CHROMATIN STRUCTURE AND REGULATION OF GENE TRANSCRIPTION IN PEDIATRIC GLIOMA by Saratsis, Amanda, Huang, Tina, Piunti, Andrea, A. Ozark, Patrick, Bartom, Elizabeth, Marshall, Stacy, Hashizume, Rintaro, David James, C, Shilatifard, Ali

“…Abstract INTRODUCTION Pediatric high-grade glioma (HGG), including H3K27M diffuse midline glioma, has the highest mortality of pediatric solid tumors…”
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PDTM-42. TARGETED INHIBITION OF BET BROMODOMAIN AND JMJD3 PROTEINS FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA by Katagi, Hiroaki, Zhang, Ali, T. Blyth, Gavin, D. Eckerdt, Frank, A. Ozark, Patrick, Zou, Lihua, He, Xingyao, E. Loughlin, Kathryn, Sasaki, Takahiro, Horbinski, Craig, R. Lulla, Rishi, M. Saratsis, Amanda, Goldman, Stewart, David James, C, Shilatifard, Ali, Hashizume, Rintaro

“…Abstract Recent discovery of somatic histone gene mutations, resulting in replacement of lysine 27 by methionine (K27M) in the encoded histone H3.3 proteins,…”
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PDTM-05. RADIATION DNA DAMAGE REPAIR INHIBITION BY GSK-J4 INDUCED CHROMATIN COMPACTION IN DIPG by Louis, Nundia, Zou, Lihua, Unruh, Dusten, A. Ozark, Patrick, Piunti, Andrea, Gorbunova, Vera, He, Xingyao, Katagi, Hiroaki, Gryzlo, Daniel, Zhang, Ali, M. Saratsis, Amanda, Laurie, Kathryn, Lulla, Rishi, Fangusaro, Jason, Horbinski, Craig, Goldman, Stewart, James, C David, Shilatifard, Ali, Hashizume, Rintaro

“…Abstract INTRODUCTION Focal radiation therapy has long been and remains the only treatment option for diffuse intrinsic pontine glioma (DIPG). However, all…”
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PDTM-39. HISTONE H3 MUTATION EFFECTS ON CHROMATIN STRUCTURE AND REGULATION OF GENE TRANSCRIPTION IN PEDIATRIC GLIOMA by Saratsis, Amanda, Huang, Tina, Piunti, Andrea, A. Ozark, Patrick, Bartom, Elizabeth, Marshall, Stacy, Hashizume, Rintaro, David James, C, Shilatifard, Ali

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