Search Results - "Ozaita, Andres"

Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams–Beuren syndrome by Navarro-Romero, Alba, Galera-López, Lorena, Ortiz-Romero, Paula, Llorente-Ovejero, Alberto, de los Reyes-Ramírez, Lucía, Bengoetxea de Tena, Iker, Garcia-Elias, Anna, Mas-Stachurska, Aleksandra, Reixachs-Solé, Marina, Pastor, Antoni, de la Torre, Rafael, Maldonado, Rafael, Benito, Begoña, Eyras, Eduardo, Rodríguez-Puertas, Rafael, Campuzano, Victoria, Ozaita, Andres

“…Williams–Beuren syndrome (WBS) is a rare genetic multisystemic disorder characterized by mild-to-moderate intellectual disability and hypersocial phenotype,…”
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Distribution of Kv3.3 potassium channel subunits in distinct neuronal populations of mouse brain by Chang, Su Ying, Zagha, Edward, Kwon, Elaine S., Ozaita, Andres, Bobik, Marketta, Martone, Maryann E., Ellisman, Mark H., Heintz, Nathaniel, Rudy, Bernardo

“…Kv3.3 proteins are pore‐forming subunits of voltage‐dependent potassium channels, and mutations in the gene encoding for Kv3.3 have recently been linked to…”
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Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling by Ozaita, Andrés, Maldonado, Rafael, Puighermanal, Emma, Marsicano, Giovanni, Busquets-Garcia, Arnau, Lutz, Beat

“…Cannabis can impair memory function. This study shows that, in mice, the active component of cannabis, via CB1 receptors on GABA interneurons and a mechanism…”
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Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain by Ozaita, Andrés, Puighermanal, Emma, Maldonado, Rafael

“…Delta9-tetrahydrocannabinol (THC), the main psychoactive component in Cannabis sativa preparations, exerts its central effects mainly through the G-protein…”
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Targeting the endocannabinoid system in the treatment of fragile X syndrome by Busquets-Garcia, Arnau, Gomis-González, Maria, Guegan, Thomas, Agustín-Pavón, Carmen, Pastor, Antoni, Mato, Susana, Pérez-Samartín, Alberto, Matute, Carlos, de la Torre, Rafael, Dierssen, Mara, Maldonado, Rafael, Ozaita, Andrés

“…Fragile X syndrome is a type of mental retardation caused by mutations in the Fmr1 gene. Now Andres Ozaita and colleagues show that blocking cannabinoid…”
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Differential Role of Anandamide and 2-Arachidonoylglycerol in Memory and Anxiety-like Responses by Busquets-Garcia, Arnau, Puighermanal, Emma, Pastor, Antoni, de la Torre, Rafael, Maldonado, Rafael, Ozaita, Andrés

“…Background Cannabinoid agonists are potential therapeutic agents because of their antinociceptive and anxiolytic-like effects, although an important caveat to…”
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Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids by Puighermanal, Emma, Busquets-Garcia, Arnau, Maldonado, Rafael, Ozaita, Andrés

“…Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the modulation of endogenous cannabinoids, affect cognitive function through the…”
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Microglial activation underlies cerebellar deficits produced by repeated cannabis exposure by Cutando, Laura, Busquets-Garcia, Arnau, Puighermanal, Emma, Gomis-González, Maria, Delgado-García, José María, Gruart, Agnès, Maldonado, Rafael, Ozaita, Andrés

“…Chronic cannabis exposure can lead to cerebellar dysfunction in humans, but the neurobiological mechanisms involved remain incompletely understood. Here, we…”
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Dissociation of the Pharmacological Effects of THC by mTOR Blockade by PUIGHERMANAL, Emma, BUSQUETS-GARCIA, Arnau, GOMIS-GONZALEZ, Maria, MARSICANO, Giovanni, MALDONADO, Rafael, OZAITA, Andres

“…The potential therapeutic benefits of cannabinoid compounds have raised interest in understanding the molecular mechanisms that underlie cannabinoid-mediated…”
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The cannabis paradox: when age matters by Ozaita, Andrés, Aso, Ester

“…New evidence in mouse models reveals that exposure to Δ 9 -tetrahydrocannabinol (THC), the main psychoactive component in Cannabis sativa , might improve…”
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Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation by Busquets-Garcia, Arnau, Gomis-González, Maria, Srivastava, Raj Kamal, Cutando, Laura, Ortega-Alvaro, Antonio, Ruehle, Sabine, Remmers, Floortje, Bindila, Laura, Bellocchio, Luigi, Marsicano, Giovanni, Lutz, Beat, Maldonado, Rafael, Ozaita, Andrés

“…Stressful events can generate emotional memories linked to the traumatic incident, but they also can impair the formation of nonemotional memories. Although…”
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Protein Kinase C-Gamma Knockout Mice Show Impaired Hippocampal Short-Term Memory While Preserved Long-Term Memory by Gomis-González, Maria, Galera-López, Lorena, Ten-Blanco, Marc, Busquets-Garcia, Arnau, Cox, Thomas, Maldonado, Rafael, Ozaita, Andrés

“…The brain encodes, stores, and retrieves relevant information in the form of memories that are classified as short-term (STM) and long-term memories (LTM)…”
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Auricular transcutaneous vagus nerve stimulation improves memory persistence in naïve mice and in an intellectual disability mouse model by Vázquez-Oliver, Anna, Brambilla-Pisoni, Cecilia, Domingo-Gainza, Mikel, Maldonado, Rafael, Ivorra, Antoni, Ozaita, Andrés

“…Vagus nerve stimulation (VNS) using non-invasive approaches have attracted great attention due to their anti-epileptic, anti-depressive and pro-cognitive…”
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Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2 by Martínez-Torres, Sara, Cutando, Laura, Pastor, Antoni, Kato, Ako, Sakimura, Kenji, de la Torre, Rafael, Valjent, Emmanuel, Maldonado, Rafael, Kano, Masanobu, Ozaita, Andrés

“…•Monoacylglycerol lipase (MAGL) inactivation increases microglial perimeter in the cerebellum.•Cerebellar microglia activation concurs with COX-2…”
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Hippocampal Protein Kinase C Signaling Mediates the Short-Term Memory Impairment Induced by Delta9-Tetrahydrocannabinol by Busquets-Garcia, Arnau, Gomis-González, Maria, Salgado-Mendialdúa, Victòria, Galera-López, Lorena, Puighermanal, Emma, Martín-García, Elena, Maldonado, Rafael, Ozaita, Andrés

“…Cannabis affects cognitive performance through the activation of the endocannabinoid system, and the molecular mechanisms involved in this process are poorly…”
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Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome by Navarro-Romero, Alba, Vázquez-Oliver, Anna, Gomis-González, Maria, Garzón-Montesinos, Carlos, Falcón-Moya, Rafael, Pastor, Antoni, Martín-García, Elena, Pizarro, Nieves, Busquets-Garcia, Arnau, Revest, Jean-Michel, Piazza, Pier-Vincenzo, Bosch, Fátima, Dierssen, Mara, de la Torre, Rafael, Rodríguez-Moreno, Antonio, Maldonado, Rafael, Ozaita, Andrés

“…Intellectual disability is the most limiting hallmark of Down syndrome, for which there is no gold-standard clinical treatment yet. The endocannabinoid system…”
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Serotonergic mechanisms involved in antidepressant-like responses evoked by GLT-1 blockade in rat infralimbic cortex by Gasull-Camós, Júlia, Martínez-Torres, Sara, Tarrés-Gatius, Mireia, Ozaita, Andrés, Artigas, Francesc, Castañé, Anna

“…Novel fast-acting antidepressant strategies, such as ketamine and deep brain stimulation, enhance glutamatergic neurotransmission in medial prefrontal cortex…”
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Auricular Transcutaneous Vagus Nerve Stimulation Acutely Modulates Brain Connectivity in Mice by Brambilla-Pisoni, Cecilia, Muñoz-Moreno, Emma, Gallego-Amaro, Ianire, Maldonado, Rafael, Ivorra, Antoni, Soria, Guadalupe, Ozaita, Andrés

“…Brain electrical stimulation techniques take advantage of the intrinsic plasticity of the nervous system, opening a wide range of therapeutic applications…”
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New insights into the molecular pathophysiology of fragile X syndrome and therapeutic perspectives from the animal model by Busquets-Garcia, Arnau, Maldonado, Rafael, Ozaita, Andrés

“…Fragile X syndrome is the most common monogenetic form of intellectual disability and is a leading cause of autism. This syndrome is produced by the reduced…”
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Sex-dependent psychoneuroendocrine effects of THC and MDMA in an animal model of adolescent drug consumption by Llorente-Berzal, Alvaro, Puighermanal, Emma, Burokas, Aurelijus, Ozaita, Andrés, Maldonado, Rafael, Marco, Eva M, Viveros, Maria-Paz

“…Ecstasy is a drug that is usually consumed by young people at the weekends and frequently, in combination with cannabis. In the present study we have…”
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