IgM in human immunity to Plasmodium falciparum malaria

Most studies on human immunity to malaria have focused on the roles of immunoglobulin G (IgG), whereas the roles of IgM remain undefined. Analyzing multiple human cohorts to assess the dynamics of malaria-specific IgM during experimentally induced and naturally acquired malaria, we identified IgM ac...

Full description

Saved in:

Bibliographic Details
Published in:	Science advances Vol. 5; no. 9; p. eaax4489
Main Authors:	Boyle, M J, Chan, J A, Handayuni, I, Reiling, L, Feng, G, Hilton, A, Kurtovic, L, Oyong, D, Piera, K A, Barber, B E, William, T, Eisen, D P, Minigo, G, Langer, C, Drew, D R, de Labastida Rivera, F, Amante, F H, Williams, T N, Kinyanjui, S, Marsh, K, Doolan, D L, Engwerda, C, Fowkes, F J I, Grigg, M J, Mueller, I, McCarthy, J S, Anstey, N M, Beeson, J G
Format:	Journal Article
Language:	English
Published:	United States American Association for the Advancement of Science 01-09-2019
Subjects:	Adolescent Adult Antibodies, Protozoan - immunology Antibody Formation - immunology Antibody Specificity - immunology Antigens, Protozoan - immunology Female Host-Parasite Interactions - immunology Humans Immunity Immunoglobulin G - immunology Immunoglobulin M - immunology Immunology Malaria, Falciparum - immunology Malaria, Falciparum - parasitology Male Microbiology Middle Aged Plasmodium falciparum - immunology SciAdv r-articles Young Adult
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Most studies on human immunity to malaria have focused on the roles of immunoglobulin G (IgG), whereas the roles of IgM remain undefined. Analyzing multiple human cohorts to assess the dynamics of malaria-specific IgM during experimentally induced and naturally acquired malaria, we identified IgM activity against blood-stage parasites. We found that merozoite-specific IgM appears rapidly in infection and is prominent during malaria in children and adults with lifetime exposure, together with IgG. Unexpectedly, IgM persisted for extended periods of time; we found no difference in decay of merozoite-specific IgM over time compared to that of IgG. IgM blocked merozoite invasion of red blood cells in a complement-dependent manner. IgM was also associated with significantly reduced risk of clinical malaria in a longitudinal cohort of children. These findings suggest that merozoite-specific IgM is an important functional and long-lived antibody response targeting blood-stage malaria parasites that contributes to malaria immunity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Present address: QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia.
ISSN:	2375-2548 2375-2548
DOI:	10.1126/sciadv.aax4489