Pregabalin for the Treatment of Neuropathic Pain: A Systematic Review of Patient-Reported Outcomes

Pregabalin for the Treatment of Neuropathic Pain: A Systematic Review of Patient-Reported Outcomes

Neuropathic pain (NeP) arises from pathologies of the nervous system, significantly impacting patient functionality and quality of life. Pregabalin is a first-line treatment for NeP, but there has been limited focus on patient-reported outcomes (PROs). This systematic review synthesizes PROs from cl...

Full description

Saved in:
Bibliographic Details
Published in:Curēus (Palo Alto, CA) Vol. 16; no. 9; p. e70443
Main Authors: Wang, Zhihui, Naeem, Iffat, Oyenola, Tinu, Khan, Ahmad Raza, Dennis, Amanda, Obamiyi, Samuel, Toews, Emilie, Singh, Shilpa, Zhu, Gebin
Format: Journal Article
Language:English
Published: United States Cureus 29-09-2024
Subjects:
Neurology
Pain Management
Psychology
patient-reported outcomes
pregabalin
neuropathic pain
sleep disturbance
quality of life
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neuropathic pain (NeP) arises from pathologies of the nervous system, significantly impacting patient functionality and quality of life. Pregabalin is a first-line treatment for NeP, but there has been limited focus on patient-reported outcomes (PROs). This systematic review synthesizes PROs from clinical studies assessing pregabalin's efficacy in treating NeP, with a focus on sleep disturbance, mental health, and health-related quality of life (HRQOL). Following Cochrane Collaboration guidelines, we conducted a systematic search of randomized controlled trials and epidemiological studies reporting PROs associated with pregabalin treatment for NeP. Sixteen studies met the inclusion criteria and were narratively synthesized. The findings indicate that pregabalin significantly improved sleep interference and HRQOL across multiple studies, particularly at doses of 300 mg/day or higher. However, improvements in mental health outcomes, such as anxiety and depression, were inconsistent across studies. No meta-analysis was conducted due to the heterogeneity of outcomes. In conclusion, while pregabalin shows robust efficacy in reducing NeP-related sleep disturbances, its effects on mental health and HRQOL are less consistent. These findings highlight the need for a more holistic approach to NeP treatment, incorporating both clinical outcomes and PROs.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.70443