Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

High-titer convalescent plasma was compared with placebo in older adult patients within the first 3 days after the onset of symptoms of Covid-19 and documented SARS-CoV-2 infection. Disease progression was approximately half as common in patients who received convalescent plasma (16%) as in those wh...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 384; no. 7; pp. 610 - 618
Main Authors:	Libster, Romina, Pérez Marc, Gonzalo, Wappner, Diego, Coviello, Silvina, Bianchi, Alejandra, Braem, Virginia, Esteban, Ignacio, Caballero, Mauricio T, Wood, Cristian, Berrueta, Mabel, Rondan, Aníbal, Lescano, Gabriela, Cruz, Pablo, Ritou, Yvonne, Fernández Viña, Valeria, Álvarez Paggi, Damián, Esperante, Sebastián, Ferreti, Adrián, Ofman, Gastón, Ciganda, Álvaro, Rodriguez, Rocío, Lantos, Jorge, Valentini, Ricardo, Itcovici, Nicolás, Hintze, Alejandra, Oyarvide, M. Laura, Etchegaray, Candela, Neira, Alejandra, Name, Ivonne, Alfonso, Julieta, López Castelo, Rocío, Caruso, Gisela, Rapelius, Sofía, Alvez, Fernando, Etchenique, Federico, Dimase, Federico, Alvarez, Darío, Aranda, Sofía S, Sánchez Yanotti, Clara, De Luca, Julián, Jares Baglivo, Sofía, Laudanno, Sofía, Nowogrodzki, Florencia, Larrea, Ramiro, Silveyra, María, Leberzstein, Gabriel, Debonis, Alejandra, Molinos, Juan, González, Miguel, Perez, Eduardo, Kreplak, Nicolás, Pastor Argüello, Susana, Gibbons, Luz, Althabe, Fernando, Bergel, Eduardo, Polack, Fernando P
Format:	Journal Article
Language:	English
Published:	United States Massachusetts Medical Society 18-02-2021
Subjects:	Adverse events Age Aged Aged, 80 and over Antibodies Blood Component Transfusion Cardiovascular disease Chronic obstructive pulmonary disease Consent Coronaviridae Coronaviruses COVID-19 COVID-19 - complications COVID-19 - therapy Diabetes Disease Progression Double-Blind Method Female Geriatrics Humans Hypertension Illnesses Immunization, Passive Immunoglobulin G Immunoglobulin G - blood Intention to Treat Analysis Kaplan-Meier Estimate Male Older people Original Pandemics Patients Placebos Plasma Respiration Respiratory diseases Respiratory Insufficiency - etiology Respiratory Insufficiency - prevention & control SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Argentina
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Summary:	High-titer convalescent plasma was compared with placebo in older adult patients within the first 3 days after the onset of symptoms of Covid-19 and documented SARS-CoV-2 infection. Disease progression was approximately half as common in patients who received convalescent plasma (16%) as in those who received placebo (31%).
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3 The Fundación INFANT–COVID-19 Group members are listed in the Supplementary Appendix, available with the full text of this article at NEJM.org. Drs. Libster and Pérez Marc contributed equally to this article.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2033700