Mutation in Bovine β-Carotene Oxygenase 2 Affects Milk Color

Mutation in Bovine β-Carotene Oxygenase 2 Affects Milk Color

beta-Carotene biochemistry is a fundamental process in mammalian biology. Aberrations either through malnutrition or potentially through genetic variation may lead to vitamin A deficiency, which is a substantial public health burden. In addition, understanding the genetic regulation of this process...

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Published in:Genetics (Austin) Vol. 182; no. 3; pp. 923 - 926
Main Authors: Berry, S.D, Davis, S.R, Beattie, E.M, Thomas, N.L, Burrett, A.K, Ward, H.E, Stanfield, A.M, Biswas, M, Andersmit-Udy, A.E, Oxley, P.E, Barnett, J.L, Pearson, J.F, Does, Y. van der, MacGibbon, A.H.K, Spelman, R.J
Format: Journal Article
Language:English
Published: United States Genetics Society of America 01-07-2009
Subjects:
Amino Acid Sequence
Animals
Base Sequence
beta Carotene - blood
beta Carotene - metabolism
beta-carotene
beta-carotene oxygenase
biosynthesis
Cattle
Chromosomes, Mammalian - genetics
Color
Crosses, Genetic
dairy cows
DNA Mutational Analysis
Female
genes
Genotype
Male
milk
Milk - chemistry
Milk - metabolism
Mutation
oxygenases
Oxygenases - genetics
Oxygenases - metabolism
Polymorphism, Single Nucleotide
quantitative trait loci
Quantitative Trait Loci - genetics
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Summary:beta-Carotene biochemistry is a fundamental process in mammalian biology. Aberrations either through malnutrition or potentially through genetic variation may lead to vitamin A deficiency, which is a substantial public health burden. In addition, understanding the genetic regulation of this process may enable bovine improvement. While many bovine QTL have been reported, few of the causative genes and mutations have been identified. We discovered a QTL for milk beta-carotene and subsequently identified a premature stop codon in bovine beta-carotene oxygenase 2 (BCO2), which also affects serum beta-carotene content. The BCO2 enzyme is thereby identified as a key regulator of beta-carotene metabolism.
Bibliography:http://www.genetics.org/
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Communicating editor: A. P. Long
Corresponding author: ViaLactia Biosciences, P.O. Box 109-185, Newmarket, Auckland 1149, New Zealand. E-mail: russell.snell@vialactia.com
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1534/genetics.109.101741