Combat Wound Initiative program

The Combat Wound Initiative (CWI) program is a collaborative, multidisciplinary, and interservice public-private partnership that provides personalized, state-of-the-art, and complex wound care via targeted clinical and translational research. The CWI uses a bench-to-bedside approach to translationa...

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Bibliographic Details
Published in:	Military medicine Vol. 175; no. 7 Suppl; pp. 18 - 24
Main Authors:	Stojadinovic, Alexander, Elster, Eric, Potter, Benjamin K, Davis, Thomas A, Tadaki, Doug K, Brown, Trevor S, Ahlers, Stephen, Attinger, Christopher E, Andersen, Romney C, Burris, David, Centeno, Jose, Champion, Hunter, Crumbley, David R, Denobile, John, Duga, Michael, Dunne, James R, Eberhardt, John, Ennis, William J, Forsberg, Jonathan A, Hawksworth, Jason, Helling, Thomas S, Lazarus, Gerald S, Milner, Stephen M, Mullick, Florabel G, Owner, Christopher R, Pasquina, Paul F, Patel, Chirag R, Peoples, George E, Nissan, Aviram, Ring, Michael, Sandberg, Glenn D, Schaden, Wolfgang, Schultz, Gregory S, Scofield, Tom, Shawen, Scott B, Sheppard, Forest R, Stannard, James P, Weina, Peter J, Zenilman, Jonathan M
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01-07-2010
Subjects:	Biomarkers Burns - therapy Clinical Trials as Topic High-Energy Shock Waves - therapeutic use Humans Military Personnel Neovascularization, Physiologic Public-Private Sector Partnerships Translational Medical Research United States Warfare Wound Healing Wounds and Injuries - therapy United States
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Summary:	The Combat Wound Initiative (CWI) program is a collaborative, multidisciplinary, and interservice public-private partnership that provides personalized, state-of-the-art, and complex wound care via targeted clinical and translational research. The CWI uses a bench-to-bedside approach to translational research, including the rapid development of a human extracorporeal shock wave therapy (ESWT) study in complex wounds after establishing the potential efficacy, biologic mechanisms, and safety of this treatment modality in a murine model. Additional clinical trials include the prospective use of clinical data, serum and wound biomarkers, and wound gene expression profiles to predict wound healing/failure and additional clinical patient outcomes following combat-related trauma. These clinical research data are analyzed using machine-based learning algorithms to develop predictive treatment models to guide clinical decision-making. Future CWI directions include additional clinical trials and study centers and the refinement and deployment of our genetically driven, personalized medicine initiative to provide patient-specific care across multiple medical disciplines, with an emphasis on combat casualty care.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0026-4075 1930-613X
DOI:	10.7205/MILMED-D-10-00156