Search Results - "Owens, T."

Decorin-evoked paternally expressed gene 3 (PEG3) is an upstream regulator of the transcription factor EB (TFEB) in endothelial cell autophagy by Neill, Thomas, Sharpe, Catherine, Owens, Rick T., Iozzo, Renato V.

“…Macroautophagy is a fundamental and evolutionarily conserved catabolic process that eradicates damaged and aging macromolecules and organelles in eukaryotic…”
Get full text

Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes by Shah, Parisha P., Lv, Wenjian, Rhoades, Joshua H., Poleshko, Andrey, Abbey, Deepti, Caporizzo, Matthew A., Linares-Saldana, Ricardo, Heffler, Julie G., Sayed, Nazish, Thomas, Dilip, Wang, Qiaohong, Stanton, Liam J., Bedi, Kenneth, Morley, Michael P., Cappola, Thomas P., Owens, Anjali T., Margulies, Kenneth B., Frank, David B., Wu, Joseph C., Rader, Daniel J., Yang, Wenli, Prosser, Benjamin L., Musunuru, Kiran, Jain, Rajan

“…Pathogenic mutations in LAMIN A/C (LMNA) cause abnormal nuclear structure and laminopathies. These diseases have myriad tissue-specific phenotypes, including…”
Get full text

Decorin causes autophagy in endothelial cells via Peg3 by Buraschi, Simone, Neill, Thomas, Goyal, Atul, Poluzzi, Chiara, Smythies, James, Owens, Rick T, Schaefer, Liliana, Torres, Annabel, Iozzo, Renato V

“…Soluble decorin affects the biology of several receptor tyrosine kinases by triggering receptor internalization and degradation. We found that decorin induced…”
Get full text

Ultra-high-field imaging distinguishes MS lesions from asymptomatic white matter lesions by TALLANTYRE, E. C, DIXON, J. E, DONALDSON, I, OWENS, T, MORGAN, P. S, MORRIS, P. G, EVANGELOU, N

“…To investigate whether multiple sclerosis (MS) and non-MS white matter brain lesions can be distinguished by their appearance on 7 T T2*-weighted MRI. This was…”
Get full text

Modeling the Effects of Stress, Anxiety, and Depression on Rumination, Sleep, and Fatigue in a Nonclinical Sample by Thorsteinsson, Einar B, Brown, Rhonda F, Owens, Michelle T

“…ABSTRACTStress and affective distress have previously been shown to predict sleep quality, and all the factors have been shown to predict fatigue severity…”
Get full text

Sound propagation and force chains in granular materials by Owens, E. T, Daniels, K. E

“…Granular materials are inherently heterogeneous, leading to challenges in formulating accurate models of sound propagation. In order to quantify acoustic…”
Get full text

Frequency, Penetrance, and Variable Expressivity of Dilated Cardiomyopathy–Associated Putative Pathogenic Gene Variants in UK Biobank Participants by Shah, Ravi A., Asatryan, Babken, Sharaf Dabbagh, Ghaith, Aung, Nay, Khanji, Mohammed Y., Lopes, Luis R., van Duijvenboden, Stefan, Holmes, Anthony, Muser, Daniele, Landstrom, Andrew P., Lee, Aaron Mark, Arora, Pankaj, Semsarian, Christopher, Somers, Virend K., Owens, Anjali T., Munroe, Patricia B., Petersen, Steffen E., Chahal, C. Anwar A.

“…There is a paucity of data regarding the phenotype of dilated cardiomyopathy (DCM) gene variants in the general population. We aimed to determine the frequency…”
Get full text

Ransomware Classification Using Hardware Performance Counters on a Non-Virtualized System by Hill, Jennie E., Owens Walker, T., Blanco, Justin A., Ives, Robert W., Rakvic, Ryan, Jacob, Bruce

“…Ransomware is a type of malicious software designed to encrypt a user's important data for the purpose of extortion, with a global annual impact of billions of…”
Get full text

Coronavirus disease 2019 in heart transplant recipients: Risk factors, immunosuppression, and outcomes by Genuardi, Michael V., Moss, Noah, Najjar, Samer S., Houston, Brian A., Shore, Supriya, Vorovich, Esther, Atluri, Pavan, Molina, Maria, Chambers, Susan, Sharkoski, Tiffany, Hsich, Eileen, Estep, Jerry D., Owens, Anjali T., Alexander, Kevin M., Chaudhry, Sunit-Preet, Garcia-Cortes, Rafael, Molina, Ezequiel, Rodrigo, Maria, Wald, MDc Joyce, Margulies, Kenneth B., Hanff, Thomas C., Zimmer, Ross, Kilic, Arman, Mclean, Rhondalyn, Vidula, Himabindu, Dodd, Katherine, Blumberg, Emily A., Mazurek, Jeremy A., Goldberg, Lee R., Alvarez-Garcia, Jesus, Mancini, Donna, Teuteberg, Jeffrey J., Tedford, Ryan J., Birati, Edo Y.

“…COVID-19 continues to inflict significant morbidity and mortality, particularly on patients with preexisting health conditions. The clinical course, outcomes,…”
Get full text

Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model by Buraschi, Simone, Neill, Thomas, Owens, Rick T, Iniguez, Leonardo A, Purkins, George, Vadigepalli, Rajanikanth, Evans, Barry, Schaefer, Liliana, Peiper, Stephen C, Wang, Zi-Xuan, Iozzo, Renato V

“…Decorin, a member of the small leucine-rich proteoglycan gene family, exists and functions wholly within the tumor microenvironment to suppress tumorigenesis…”
Get full text

Modulation of canonical Wnt signaling by the extracellular matrix component biglycan by Berendsen, Agnes D, Fisher, Larry W, Kilts, Tina M, Owens, Rick T, Robey, Pamela G, Gutkind, J. Silvio, Young, Marian F

“…Although extracellular control of canonical Wnt signaling is crucial for tissue homeostasis, the role of the extracellular microenvironment in modulating this…”
Get full text

Decorin is a novel antagonistic ligand of the Met receptor by Goldoni, Silvia, Humphries, Ashley, Nyström, Alexander, Sattar, Sampurna, Owens, Rick T, McQuillan, David J, Ireton, Keith, Iozzo, Renato V

“…Decorin, a member of the small leucine-rich proteoglycan gene family, impedes tumor cell growth by down-regulating the epidermal growth factor receptor…”
Get full text

Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells by Goyal, Atul, Neill, Thomas, Owens, Rick T., Schaefer, Liliana, Iozzo, Renato V.

“…The highly conserved eukaryotic process of macroautophagy (autophagy) is a non-specific bulk-degradation program critical for maintaining proper cellular…”
Get full text

Clinical Interpretations of Patient Experience in a Trial of Psilocybin-Assisted Psychotherapy for Alcohol Use Disorder by Bogenschutz, Michael P, Podrebarac, Samantha K, Duane, Jessie H, Amegadzie, Sean S, Malone, Tara C, Owens, Lindsey T, Ross, Stephen, Mennenga, Sarah E

“…After a hiatus of some 40 years, clinical research has resumed on the use of classic hallucinogens to treat addiction. Following completion of a small…”
Get full text

Retinal Input Instructs Alignment of Visual Topographic Maps by Triplett, Jason W., Owens, Melinda T., Yamada, Jena, Lemke, Greg, Cang, Jianhua, Stryker, Michael P., Feldheim, David A.

“…Sensory information is represented in the brain in the form of topographic maps, in which neighboring neurons respond to adjacent external stimuli. In the…”
Get full text

Stochastic Interaction between Neural Activity and Molecular Cues in the Formation of Topographic Maps by Owens, Melinda T., Feldheim, David A., Stryker, Michael P., Triplett, Jason W.

“…Topographic maps in visual processing areas maintain the spatial order of the visual world. Molecular cues and neuronal activity both play critical roles in…”
Get full text

Regional variations in the extent and pattern of grey matter demyelination in multiple sclerosis: a comparison between the cerebral cortex, cerebellar cortex, deep grey matter nuclei and the spinal cord by Gilmore, C P, Donaldson, I, Bö, L, Owens, T, Lowe, J, Evangelou, N

“…Background:Substantial grey matter (GM) demyelination occurs in both the cerebral cortex and spinal cord in multiple sclerosis (MS). GM demyelination also…”
Get full text

Genetic Evidence for the Coordinated Regulation of Collagen Fibrillogenesis in the Cornea by Decorin and Biglycan by Zhang, Guiyun, Chen, Shoujun, Goldoni, Silvia, Calder, Bennett W., Simpson, Holly C., Owens, Rick T., McQuillan, David J., Young, Marian F., Iozzo, Renato V., Birk, David E.

“…Decorin and biglycan are class I small leucine-rich proteoglycans (SLRPs) involved in regulation of collagen fibril and matrix assembly. We hypothesize that…”
Get full text

Mavacamten for Obstructive Hypertrophic Cardiomyopathy: Rationale for Clinically Guided Dose Titration to Optimize Individual Response by Owens, Anjali T, Desai, Milind, Wheeler, Matthew T, Rodonski, Anna, Merali, Samira, Sehnert, Amy J, Saberi, Sara

“…Mavacamten is the first and only cardiac myosin inhibitor approved in 5 continents for the treatment of adults with symptomatic New York Heart Association…”
Get full text

Individual Experiences in Four Cancer Patients Following Psilocybin-Assisted Psychotherapy by Malone, Tara C, Mennenga, Sarah E, Guss, Jeffrey, Podrebarac, Samantha K, Owens, Lindsey T, Bossis, Anthony P, Belser, Alexander B, Agin-Liebes, Gabrielle, Bogenschutz, Michael P, Ross, Stephen

“…A growing body of evidence shows that existential and spiritual well-being in cancer patients is associated with better medical outcomes, improved quality of…”
Get full text