Search Results - "Owens, Raymond J."

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

“…There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor…”
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A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19 by Huo, Jiandong, Mikolajek, Halina, Le Bas, Audrey, Clark, Jordan J., Sharma, Parul, Kipar, Anja, Dormon, Joshua, Norman, Chelsea, Weckener, Miriam, Clare, Daniel K., Harrison, Peter J., Tree, Julia A., Buttigieg, Karen R., Salguero, Francisco J., Watson, Robert, Knott, Daniel, Carnell, Oliver, Ngabo, Didier, Elmore, Michael J., Fotheringham, Susan, Harding, Adam, Moynié, Lucile, Ward, Philip N., Dumoux, Maud, Prince, Tessa, Hall, Yper, Hiscox, Julian A., Owen, Andrew, James, William, Carroll, Miles W., Stewart, James P., Naismith, James H., Owens, Raymond J.

“…SARS-CoV-2 remains a global threat to human health particularly as escape mutants emerge. There is an unmet need for effective treatments against COVID-19 for…”
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Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1 by Mycroft-West, Courtney J., Abdelkarim, Sahar, Duyvesteyn, Helen M. E., Gandhi, Neha S., Skidmore, Mark A., Owens, Raymond J., Wu, Liang

“…Heparan sulfate (HS) polysaccharides are major constituents of the extracellular matrix, which are involved in myriad structural and signaling processes…”
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Structural Biology of Nanobodies against the Spike Protein of SARS-CoV-2 by Tang, Qilong, Owens, Raymond J, Naismith, James H

“…Nanobodies are 130 amino acid single-domain antibodies (V H) derived from the unique heavy-chain-only subclass of Camelid immunogloblins. Their small molecular…”
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Molecular basis for GTP recognition by light‐activated guanylate cyclase RhGC by Butryn, Agata, Raza, Hadeeqa, Rada, Heather, Moraes, Isabel, Owens, Raymond J., Orville, Allen M.

“…Cyclic guanosine 3′,5′‐monophosphate (cGMP) is an intracellular signalling molecule involved in many sensory and developmental processes. Synthesis of cGMP…”
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Marine picocyanobacterial PhnD1 shows specificity for various phosphorus sources but likely represents a constitutive inorganic phosphate transporter by Shah, Bhumika S., Ford, Benjamin A., Varkey, Deepa, Mikolajek, Halina, Orr, Christian, Mykhaylyk, Vitaliy, Owens, Raymond J., Paulsen, Ian T.

“…Despite being fundamental to multiple biological processes, phosphorus (P) availability in marine environments is often growth-limiting, with generally low…”
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Screening of Membrane Protein Production by Comparison of Transient Expression in Insect and Mammalian Cells by Kaipa, Jagan Mohan, Krasnoselska, Ganna, Owens, Raymond J, van den Heuvel, Joop

“…Membrane proteins are difficult biomolecules to express and purify. In this paper, we compare the small-scale production of six selected eukaryotic integral…”
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Expression of recombinant glycoproteins in mammalian cells: towards an integrative approach to structural biology by Aricescu, A Radu, Owens, Raymond J

“…•Mammalian cell expression is an essential tool for integrative structural biology.•Se-Met, isotope and non-natural amino acid labeled glycoproteins can be…”
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Fragment library screening by X-ray crystallography and binding site analysis on thioredoxin glutathione reductase of Schistosoma mansoni by de Souza Neto, Lauro Ribeiro, Montoya, Bogar Omar, Brandão-Neto, José, Verma, Anil, Bowyer, Sebastian, Moreira-Filho, José Teófilo, Dantas, Rafael Ferreira, Neves, Bruno Junior, Andrade, Carolina Horta, von Delft, Frank, Owens, Raymond J., Furnham, Nicholas, Silva-Jr, Floriano Paes

“…Schistosomiasis is caused by parasites of the genus Schistosoma , which infect more than 200 million people. Praziquantel (PZQ) has been the main drug for…”
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Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation by Rödström, Karin E. J., Cloake, Alexander, Sörmann, Janina, Baronina, Agnese, Smith, Kathryn H. M., Pike, Ashley C. W., Ang, Jackie, Proks, Peter, Schewe, Marcus, Holland-Kaye, Ingelise, Bushell, Simon R., Elliott, Jenna, Pardon, Els, Baukrowitz, Thomas, Owens, Raymond J., Newstead, Simon, Steyaert, Jan, Carpenter, Elisabeth P., Tucker, Stephen J.

“…Potassium channels of the Two-Pore Domain (K2P) subfamily, KCNK1-KCNK18 , play crucial roles in controlling the electrical activity of many different cell…”
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Human DDX17 Unwinds Rift Valley Fever Virus Non-Coding RNAs by Nelson, Corey R, Mrozowich, Tyler, Park, Sean M, D'souza, Simmone, Henrickson, Amy, Vigar, Justin R J, Wieden, Hans-Joachim, Owens, Raymond J, Demeler, Borries, Patel, Trushar R

“…Rift Valley fever virus (RVFV) is a mosquito-transmitted virus from the family that causes high rates of mortality and morbidity in humans and ruminant…”
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Structure and functionality in flavivirus NS-proteins: Perspectives for drug design by Bollati, Michela, Alvarez, Karin, Assenberg, René, Baronti, Cécile, Canard, Bruno, Cook, Shelley, Coutard, Bruno, Decroly, Etienne, de Lamballerie, Xavier, Gould, Ernest A., Grard, Gilda, Grimes, Jonathan M., Hilgenfeld, Rolf, Jansson, Anna M., Malet, Hélène, Mancini, Erika J., Mastrangelo, Eloise, Mattevi, Andrea, Milani, Mario, Moureau, Grégory, Neyts, Johan, Owens, Raymond J., Ren, Jingshan, Selisko, Barbara, Speroni, Silvia, Steuber, Holger, Stuart, David I., Unge, Torsten, Bolognesi, Martino

“…Flaviviridae are small enveloped viruses hosting a positive-sense single-stranded RNA genome. Besides yellow fever virus, a landmark case in the history of…”
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The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif by Lukacik, Petra, Owen, C David, Harris, Gemma, Bolla, Jani Reddy, Picaud, Sarah, Alibay, Irfan, Nettleship, Joanne E, Bird, Louise E, Owens, Raymond J, Biggin, Philip C, Filippakopoulos, Panagis, Robinson, Carol V, Walsh, Martin A

“…Nontypeable Haemophilus influenzae (NTHi) is a significant pathogen in respiratory disease and otitis media. Important for NTHi survival, colonization and…”
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Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication by ASSENBERG, René, MASTRANGELO, Eloise, WALTER, Thomas S, VERMA, Anil, MILANI, Mario, OWENS, Raymond J, STUART, David I, GRIMES, Jonathan M, MANCINI, Erika J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Structural and functional insights of RANKL-RANK interaction and signaling by Liu, Changzhen, Walter, Thomas S, Huang, Peng, Zhang, Shiqian, Zhu, Xuekai, Wu, Ying, Wedderburn, Lucy R, Tang, Peifu, Owens, Raymond J, Stuart, David I, Ren, Jingshan, Gao, Bin

“…Bone remodeling involves bone resorption by osteoclasts and synthesis by osteoblasts and is tightly regulated by the receptor activator of the NF-kappaB ligand…”
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

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Recent advances in the production of proteins in insect and mammalian cells for structural biology by Nettleship, Joanne E., Assenberg, René, Diprose, Jonathan M., Rahman-Huq, Nahid, Owens, Raymond J.

“…The production of proteins in sufficient quantity and of appropriate quality is an essential pre-requisite for structural studies. Escherichia coli remains the…”
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Chemistry towards Biology-Instruct: Snapshot by Hricovíni, Miloš, Owens, Raymond J, Bak, Andrzej, Kozik, Violetta, Musiał, Witold, Pierattelli, Roberta, Májeková, Magdaléna, Rodríguez, Yoel, Musioł, Robert, Slodek, Aneta, Štarha, Pavel, Piętak, Karina, Słota, Dagmara, Florkiewicz, Wioletta, Sobczak-Kupiec, Agnieszka, Jampílek, Josef

“…The knowledge of interactions between different molecules is undoubtedly the driving force of all contemporary biomedical and biological sciences. Chemical…”
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Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport by Beale, John H., Parker, Joanne L., Samsudin, Firdaus, Barrett, Anne L., Senan, Anish, Bird, Louise E., Scott, David, Owens, Raymond J., Sansom, Mark S.P., Tucker, Stephen J., Meredith, David, Fowler, Philip W., Newstead, Simon

“…Mammals obtain nitrogen via the uptake of di- and tri-peptides in the gastrointestinal tract through the action of PepT1 and PepT2, which are members of the…”
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Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals by Parker, Joanne L, Deme, Justin C, Wu, Zhiyi, Kuteyi, Gabriel, Huo, Jiandong, Owens, Raymond J, Biggin, Philip C, Lea, Susan M, Newstead, Simon

“…The SLC15 family of proton-coupled solute carriers PepT1 and PepT2 play a central role in human physiology as the principal route for acquiring and retaining…”
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