Search Results - "Owens, Nick D.L."

Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions by Di Meglio, Paola, Duarte, João H., Ahlfors, Helena, Owens, Nick D.L., Li, Ying, Villanova, Federica, Tosi, Isabella, Hirota, Keiji, Nestle, Frank O., Mrowietz, Ulrich, Gilchrist, Michael J., Stockinger, Brigitta

“…Environmental stimuli are known to contribute to psoriasis pathogenesis and that of other autoimmune diseases, but the mechanisms are largely unknown. Here we…”
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Measuring Absolute RNA Copy Numbers at High Temporal Resolution Reveals Transcriptome Kinetics in Development by Owens, Nick D.L., Blitz, Ira L., Lane, Maura A., Patrushev, Ilya, Overton, John D., Gilchrist, Michael J., Cho, Ken W.Y., Khokha, Mustafa K.

“…Transcript regulation is essential for cell function, and misregulation can lead to disease. Despite technologies to survey the transcriptome, we lack a…”
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Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus by Gentsch, George E., Spruce, Thomas, Monteiro, Rita S., Owens, Nick D.L., Martin, Stephen R., Smith, James C.

“…Antisense morpholino oligomers (MOs) have been indispensable tools for developmental biologists to transiently knock down (KD) genes rather than to knock them…”
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Molecular asymmetry in the 8-cell stage Xenopus tropicalis embryo described by single blastomere transcript sequencing by De Domenico, Elena, Owens, Nick D.L., Grant, Ian M., Gomes-Faria, Rosa, Gilchrist, Michael J.

“…Correct development of the vertebrate body plan requires the early definition of two asymmetric, perpendicular axes. The first axis is established during…”
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In Vivo T-Box Transcription Factor Profiling Reveals Joint Regulation of Embryonic Neuromesodermal Bipotency by Gentsch, George E., Owens, Nick D.L., Martin, Stephen R., Piccinelli, Paul, Faial, Tiago, Trotter, Matthew W.B., Gilchrist, Michael J., Smith, James C.

“…The design of effective cell replacement therapies requires detailed knowledge of how embryonic stem cells form primary tissues, such as mesoderm or…”
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The Spatiotemporal Control of Zygotic Genome Activation by Gentsch, George E, Owens, Nick D L, Smith, James C

“…One of the earliest and most significant events in embryonic development is zygotic genome activation (ZGA). In several species, bulk transcription begins at…”
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Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals by Gentsch, George E., Spruce, Thomas, Owens, Nick D. L., Smith, James C.

“…Embryonic development yields many different cell types in response to just a few families of inductive signals. The property of signal-receiving cells that…”
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Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR by Sempou, Emily, Kostiuk, Valentyna, Zhu, Jie, Cecilia Guerra, M., Tyan, Leonid, Hwang, Woong, Camacho-Aguilar, Elena, Caplan, Michael J., Zenisek, David, Warmflash, Aryeh, Owens, Nick D. L., Khokha, Mustafa K.

“…Transitioning from pluripotency to differentiated cell fates is fundamental to both embryonic development and adult tissue homeostasis. Improving our…”
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Non-coding variants disrupting a tissue-specific regulatory element in HK1 cause congenital hyperinsulinism by Wakeling, Matthew N., Owens, Nick D. L., Hopkinson, Jessica R., Johnson, Matthew B., Houghton, Jayne A. L., Dastamani, Antonia, Flaxman, Christine S., Wyatt, Rebecca C., Hewat, Thomas I., Hopkins, Jasmin J., Laver, Thomas W., van Heugten, Rachel, Weedon, Michael N., De Franco, Elisa, Patel, Kashyap A., Ellard, Sian, Morgan, Noel G., Cheesman, Edmund, Banerjee, Indraneel, Hattersley, Andrew T., Dunne, Mark J., Richardson, Sarah J., Flanagan, Sarah E.

“…Gene expression is tightly regulated, with many genes exhibiting cell-specific silencing when their protein product would disrupt normal cellular function 1 …”
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High-resolution analysis of gene activity during the Xenopus mid-blastula transition by Collart, Clara, Owens, Nick D L, Bhaw-Rosun, Leena, Cooper, Brook, De Domenico, Elena, Patrushev, Ilya, Sesay, Abdul K, Smith, James N, Smith, James C, Gilchrist, Michael J

“…The Xenopus mid-blastula transition (MBT) marks the onset of large-scale zygotic transcription, as well as an increase in cell cycle length and a loss of…”
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Primate-specific ZNF808 is essential for pancreatic development in humans by De Franco, Elisa, Owens, Nick D. L., Montaser, Hossam, Wakeling, Matthew N., Saarimäki-Vire, Jonna, Triantou, Athina, Ibrahim, Hazem, Balboa, Diego, Caswell, Richard C., Jennings, Rachel E., Kvist, Jouni A., Johnson, Matthew B., Muralidharan, Sachin, Ellard, Sian, Wright, Caroline F., Maddirevula, Sateesh, Alkuraya, Fowzan S., Hanley, Neil A., Flanagan, Sarah E., Otonkoski, Timo, Hattersley, Andrew T., Imbeault, Michael

“…Identifying genes linked to extreme phenotypes in humans has the potential to highlight biological processes not shared with all other mammals. Here, we report…”
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Chromosome 20p11.2 deletions cause congenital hyperinsulinism via the loss of FOXA2 or its regulatory elements by Laver, Thomas W, Wakeling, Matthew N, Caswell, Richard C, Bunce, Benjamin, Yau, Daphne, Männistö, Jonna M E, Houghton, Jayne A L, Hopkins, Jasmin J, Weedon, Michael N, Saraff, Vrinda, Kershaw, Melanie, Honey, Engela M, Murphy, Nuala, Giri, Dinesh, Nath, Stuart, Tangari Saredo, Ana, Banerjee, Indraneel, Hussain, Khalid, Owens, Nick D L, Flanagan, Sarah E

“…Persistent congenital hyperinsulinism (HI) is a rare genetically heterogeneous condition characterised by dysregulated insulin secretion leading to…”
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Chromatin accessibility and transcription factor binding through the perspective of mitosis by Coux, Rémi-Xavier, Owens, Nick D.L., Navarro, Pablo

“…Chromatin accessibility is generally perceived as a common property of active regulatory elements where transcription factors are recruited via DNA-specific…”
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The Innate Immune Response of Frog Embryos to Antisense Morpholino Oligomers Depends on Developmental Stage, GC Content and Dose by Gentsch, George E., Spruce, Thomas, Owens, Nick D.L., Monteiro, Rita S., Smith, James C.

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Developmentally regulated long non-coding RNAs in Xenopus tropicalis by Forouzmand, Elmira, Owens, Nick D.L., Blitz, Ira L., Paraiso, Kitt D., Khokha, Mustafa K., Gilchrist, Michael J., Xie, Xiaohui, Cho, Ken W.Y.

“…Advances in RNA sequencing technologies have led to the surprising discovery that a vast number of transcripts emanate from regions of the genome that are not…”
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Expression of ribosomopathy genes during Xenopus tropicalis embryogenesis by Robson, Andrew, Owens, Nick D L, Baserga, Susan J, Khokha, Mustafa K, Griffin, John N

“…Because ribosomes are ubiquitously required for protein production, it was long assumed that any inherited defect in ribosome manufacture would be…”
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The Receptor Density Algorithm by Owens, Nick D.L., Greensted, Andrew, Timmis, Jon, Tyrrell, Andy

“…This paper describes the biological and theoretical foundations of a new Artificial Immune System the Receptor Density Algorithm. The algorithm is developed…”
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Efficient high-throughput sequencing of a laser microdissected chromosome arm by Seifertova, Eva, Zimmerman, Lyle B, Gilchrist, Michael J, Macha, Jaroslav, Kubickova, Svatava, Cernohorska, Halina, Zarsky, Vojtech, Owens, Nick D L, Sesay, Abdul K, Tlapakova, Tereza, Krylov, Vladimir

“…Genomic sequence assemblies are key tools for a broad range of gene function and evolutionary studies. The diploid amphibian Xenopus tropicalis plays a pivotal…”
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A large pseudoautosomal region on the sex chromosomes of the frog Silurana tropicalis by Bewick, Adam J, Chain, Frédéric J J, Zimmerman, Lyle B, Sesay, Abdul, Gilchrist, Michael J, Owens, Nick D L, Seifertova, Eva, Krylov, Vladimir, Macha, Jaroslav, Tlapakova, Tereza, Kubickova, Svatava, Cernohorska, Halina, Zarsky, Vojtech, Evans, Ben J

“…Sex chromosome divergence has been documented across phylogenetically diverse species, with amphibians typically having cytologically nondiverged…”
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Chemical Detection Using the Receptor Density Algorithm by Hilder, J. A., Owens, N. D. L., Neal, M. J., Hickey, P. J., Cairns, S. N., Kilgour, D. P. A., Timmis, J., Tyrrell, A. M.

“…This paper describes the application of the receptor density algorithm, an artificial immune system, as used to detect chemicals from data provided by various…”
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