Search Results - "Owens, Benjamin M.J."

The Intracellular Sensor NOD2 Induces MicroRNA-29 Expression in Human Dendritic Cells to Limit IL-23 Release by Brain, Oliver, Owens, Benjamin M.J., Pichulik, Tica, Allan, Philip, Khatamzas, Elham, Leslie, Alasdair, Steevels, Tessa, Sharma, Sameer, Mayer, Alice, Catuneanu, Ana Maria, Morton, Victoria, Sun, Mei-Yi, Jewell, Derek, Coccia, Margherita, Harrison, Oliver, Maloy, Kevin, Schönefeldt, Susann, Bornschein, Simon, Liston, Adrian, Simmons, Alison

“…NOD2 is an intracellular sensor that contributes to immune defense and inflammation. Here we investigated whether NOD2 mediates its effects through control of…”
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Inhibition of receptor tyrosine kinases restores immunocompetence and improves immune-dependent chemotherapy against experimental leishmaniasis in mice by Dalton, Jane E, Maroof, Asher, Owens, Benjamin M J, Narang, Priyanka, Johnson, Katherine, Brown, Najmeeyah, Rosenquist, Lovisa, Beattie, Lynette, Coles, Mark, Kaye, Paul M

“…Receptor tyrosine kinases are involved in multiple cellular processes, and drugs that inhibit their action are used in the clinic to treat several types of…”
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The alarmin IL-33 promotes regulatory T-cell function in the intestine by Schiering, Chris, Krausgruber, Thomas, Chomka, Agnieszka, Fröhlich, Anja, Adelmann, Krista, Wohlfert, Elizabeth A., Pott, Johanna, Griseri, Thibault, Bollrath, Julia, Hegazy, Ahmed N., Harrison, Oliver J., Owens, Benjamin M. J., Löhning, Max, Belkaid, Yasmine, Fallon, Padraic G., Powrie, Fiona

“…The alarmin interleukin-33 is constitutively expressed at barrier sites and released in response to tissue damage; here, the IL-33 receptor ST2 is shown to be…”
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Interferon Regulatory Factor 7 Contributes to the Control of Leishmania donovani in the Mouse Liver by Beattie, Lynette, Phillips, Rebecca, Brown, Najmeeyah, Owens, Benjamin M.J, Chauhan, Neal, Dalton, Jane E, Kaye, Paul M

“…Optimal hepatic resistance to Leishmania donovani in mice requires the coordinated effort of a variety of leukocyte populations that together induce activation…”
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Stromal cell induction of regulatory dendritic cells by Owens, Benjamin M J, Kaye, Paul M

“…Dendritic cells (DCs) are specialized antigen presenting cells of bone marrow origin that can exist in tissues in either an immature or mature state. DCs have…”
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Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease by West, Nathaniel R, Hegazy, Ahmed N, Owens, Benjamin M J, Bullers, Samuel J, Linggi, Bryan, Buonocore, Sofia, Coccia, Margherita, Görtz, Dieter, This, Sébastien, Stockenhuber, Krista, Pott, Johanna, Friedrich, Matthias, Ryzhakov, Grigory, Baribaud, Frédéric, Brodmerkel, Carrie, Cieluch, Constanze, Rahman, Nahid, Müller-Newen, Gerhard, Owens, Raymond J, Kühl, Anja A, Maloy, Kevin J, Plevy, Scott E, Keshav, Satish, Travis, Simon P L, Powrie, Fiona

“…The cytokine oncostatin M drives intestinal inflammation in mice, and its abundance in the intestine of patients with inflammatory bowel disease predicts…”
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Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation by Hegazy, Ahmed N., West, Nathaniel R., Stubbington, Michael J.T., Wendt, Emily, Suijker, Kim I.M., Datsi, Angeliki, This, Sebastien, Danne, Camille, Campion, Suzanne, Duncan, Sylvia H., Owens, Benjamin M.J., Uhlig, Holm H., McMichael, Andrew, Bergthaler, Andreas, Teichmann, Sarah A., Keshav, Satish, Powrie, Fiona

“…Interactions between commensal microbes and the immune system are tightly regulated and maintain intestinal homeostasis, but little is known about these…”
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The oncostatin M‐stromal cell axis in health and disease by West, Nathaniel R., Owens, Benjamin M. J., Hegazy, Ahmed N.

“…The field of stromal immunology has risen to prominence in the last decade, fuelled by accumulating evidence that nonhaematopoietic mesenchymal cells are not…”
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Siltuximab downregulates interleukin-8 and pentraxin 3 to improve ventilatory status and survival in severe COVID-19 by Gritti, Giuseppe, Raimondi, Federico, Bottazzi, Barbara, Ripamonti, Diego, Riva, Ivano, Landi, Francesco, Alborghetti, Leonardo, Frigeni, Marco, Damiani, Marianna, Micò, Caterina, Fagiuoli, Stefano, Lorini, Ferdinando Luca, Gandini, Lucia, Novelli, Luca, Morgan, Jonathan P., Owens, Benjamin M. J., Kanhai, Karan J. K., Reljanovic, Gordana Tonkovic, Rizzi, Marco, Di Marco, Fabiano, Mantovani, Alberto, Rambaldi, Alessandro

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Inflammation, Innate Immunity, and the Intestinal Stromal Cell Niche: Opportunities and Challenges by Owens, Benjamin M J

“…Stromal cells of multiple tissues contribute to immune-mediated protective responses and, conversely, the pathological tissue changes associated with chronic…”
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ADOPT: intrinsic protein disorder prediction through deep bidirectional transformers by Redl, Istvan, Fisicaro, Carlo, Dutton, Oliver, Hoffmann, Falk, Henderson, Louie, Owens, Benjamin M J, Heberling, Matthew, Paci, Emanuele, Tamiola, Kamil

“…Abstract Intrinsically disordered proteins (IDPs) are important for a broad range of biological functions and are involved in many diseases. An understanding…”
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IL-10-producing Th1 cells and disease progression are regulated by distinct CD11c⁺ cell populations during visceral leishmaniasis by Owens, Benjamin M J, Beattie, Lynette, Moore, John W J, Brown, Najmeeyah, Mann, Jason L, Dalton, Jane E, Maroof, Asher, Kaye, Paul M

“…IL-10 is a critical regulatory cytokine involved in the pathogenesis of visceral leishmaniasis caused by Leishmania donovani and clinical and experimental data…”
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Stromal cell regulation of homeostatic and inflammatory lymphoid organogenesis by Kain, Matthew J. W., Owens, Benjamin M. J.

“…Summary Secondary lymphoid organs function to increase the efficiency of interactions between rare, antigen‐specific lymphocytes and antigen presenting cells,…”
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CD4+ Recent Thymic Emigrants Are Recruited into Granulomas during Leishmania donovani Infection but Have Limited Capacity for Cytokine Production by Moore, John W J, Beattie, Lynette, Osman, Mohamed, Owens, Benjamin M J, Brown, Najmeeyah, Dalton, Jane E, Maroof, Asher, Kaye, Paul M

“…Recent thymic emigrants (RTEs) represent a source of antigen-naïve T cells that enter the periphery throughout life. However, whether RTEs contribute to the…”
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Antiviral activity of bone morphogenetic proteins and activins by Eddowes, Lucy A., Al-Hourani, Kinda, Ramamurthy, Narayan, Frankish, Jamie, Baddock, Hannah T, Sandor, Cynthia, Ryan, John D., Fusco, Dahlene N., Arezes, João, Giannoulatou, Eleni, Boninsegna, Sara, Chevaliez, Stephane, Owens, Benjamin M. J., Sun, Chia Chi, Fabris, Paolo, Giordani, Maria Teresa, Martines, Diego, Vukicevic, Slobodan, Crowe, John, Lin, Herbert Y., Rehwinkel, Jan, McHugh, Peter J., Binder, Marco, Babitt, Jodie L., Chung, Raymond T., Lawless, Matthew W., Armitage, Andrew E., Webber, Caleb, Klenerman, Paul, Drakesmith, Hal

“…Understanding the control of viral infections is of broad importance. Chronic hepatitis C virus (HCV) infection causes decreased expression of the iron hormone…”
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IRF7 regulates TLR2-mediated activation of splenic CD11c(hi) dendritic cells by Owens, Benjamin M J, Moore, John W J, Kaye, Paul M

“…Members of the Interferon Regulatory Factor (IRF) family of transcription factors play an essential role in the development and function of the immune system…”
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B cell: T cell interactions occur within hepatic granulomas during experimental visceral leishmaniasis by Moore, John W J, Beattie, Lynette, Dalton, Jane E, Owens, Benjamin M J, Maroof, Asher, Coles, Mark C, Kaye, Paul M

“…Hepatic resistance to Leishmania donovani infection in mice is associated with the development of granulomas, in which a variety of lymphoid and non-lymphoid…”
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CD90(+) Stromal Cells are Non-Professional Innate Immune Effectors of the Human Colonic Mucosa by Owens, Benjamin M J, Steevels, Tessa A M, Dudek, Michael, Walcott, David, Sun, Mei-Yi, Mayer, Alice, Allan, Philip, Simmons, Alison

“…Immune responses at the intestinal mucosa must allow for host protection whilst simultaneously avoiding inappropriate inflammation. Although much work has…”
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IL-10-producing Th1 cells and disease progression are regulated by distinct [CD11c.sup.+] cell populations during visceral leishmaniasis by Owens, Benjamin M.J, Beattie, Lynette, Moore, John W.J, Brown, Najmeeyah, Mann, Jason L, Dalton, Jane E, Maroof, Asher, Kaye, Paul M

“…IL-10 is a critical regulatory cytokine involved in the pathogenesis of visceral leishmaniasis caused by Leishmania donovani and clinical and experimental data…”
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Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate by de Souza, J Brian, Okomo, Uduak, Alexander, Neal D, Aziz, Naveed, Owens, Benjamin M J, Kaur, Harparkash, Jasseh, Momodou, Muangnoicharoen, Sant, Sumariwalla, Percy F, Warhurst, David C, Ward, Stephen A, Conway, David J, Ulloa, Luis, Tracey, Kevin J, Foxwell, Brian M J, Kaye, Paul M, Walther, Michael

“…Safe, cheap and effective adjunct therapies preventing the development of, or reducing the mortality from, severe malaria could have considerable and rapid…”
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