Search Results - "Owens, Ashley"

Real-Time Cellular Thermal Shift Assay to Monitor Target Engagement by Sanchez, Tino W., Ronzetti, Michael H., Owens, Ashley E., Antony, Maria, Voss, Ty, Wallgren, Eric, Talley, Daniel, Balakrishnan, Krishna, Leyes Porello, Sebastian E., Rai, Ganesha, Marugan, Juan J., Michael, Samuel G., Baljinnyam, Bolormaa, Southall, Noel, Simeonov, Anton, Henderson, Mark J.

“…Determining a molecule’s mechanism of action is paramount during chemical probe development and drug discovery. The cellular thermal shift assay (CETSA) is a…”
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High-Throughput Cellular Thermal Shift Assay Using Acoustic Transfer of Protein Lysates by Owens, Ashley E, Iannotti, Michael J, Sanchez, Tino W, Voss, Ty, Kapoor, Abhijeet, Hall, Matthew D, Marugan, Juan J, Michael, Sam, Southall, Noel, Henderson, Mark J

“…Cellular thermal shift assay (CETSA) is a valuable method to confirm target engagement within a complex cellular environment, by detecting changes in a…”
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Sensory gating scales and premonitory urges in Tourette syndrome by Sutherland Owens, Ashley N, Miguel, Euripedes C, Swerdlow, Neal R

“…Sensory and sensorimotor gating deficits characterize both Tourette syndrome (TS) and schizophrenia. Premonitory urges (PU) in TS can be assessed with the…”
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Amphetamine effects on startle gating in normal women and female rats by Talledo, Jo A., Sutherland Owens, Ashley N., Schortinghuis, Tijmen, Swerdlow, Neal R.

“…Background Dopamine agonists disrupt prepulse inhibition (PPI) of startle in male rodents. In humans, this is observed only in some studies. We reported that…”
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Identifying Disease Signatures in the Spinocerebellar Ataxia Type 1 Mouse Cortex by Luttik, Kimberly, Olmos, Victor, Owens, Ashley, Khan, Aryaan, Yun, Joy, Driessen, Terri, Lim, Janghoo

“…The neurodegenerative disease spinocerebellar ataxia type 1 (SCA1) is known to lead to the progressive degeneration of specific neuronal populations, including…”
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Prophylactic treatment with the c-Abl inhibitor, neurotinib, diminishes neuronal damage and the convulsive state in pilocarpine-induced mice by Chandía-Cristi, América, Gutiérrez, Daniela A., Dulcey, Andrés E., Lara, Marcelo, Vargas, Lina, Lin, Yi-Han, Jimenez-Muñoz, Pablo, Larenas, Gabriela, Xu, Xin, Wang, Amy, Owens, Ashley, Dextras, Christopher, Chen, YuChi, Pinto, Claudio, Marín, Tamara, Almarza-Salazar, Hugo, Acevedo, Keryma, Cancino, Gonzalo I., Hu, Xin, Rojas, Patricio, Ferrer, Marc, Southall, Noel, Henderson, Mark J., Zanlungo, Silvana, Marugan, Juan J., Álvarez R, Alejandra

“…The molecular mechanisms underlying seizure generation remain elusive, yet they are crucial for developing effective treatments for epilepsy. The current study…”
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A Learning Trajectory in 6-Year-Olds' Thinking About Generalizing Functional Relationships by Blanton, Maria, Brizuela, Bárbara M, Gardiner, Angela Murphy, Sawrey, Katie, Newman-Owens, Ashley

“…The study of functions is a critical route into teaching and learning algebra in the elementary grades, yet important questions remain regarding the nature of…”
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Pramipexole effects on startle gating in rats and normal men by Swerdlow, Neal R., Lelham, Sophia A., Sutherland Owens, Ashley N., Chang, Wei-Li, Sassen, Sebastiaan D. T., Talledo, Jo A.

“…Background Dopamine D3 receptors regulate sensorimotor gating in rats, as evidenced by changes in prepulse inhibition (PPI) of startle after acute…”
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Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling by Chokshi, Varun, Gao, Ming, Grier, Bryce D., Owens, Ashley, Wang, Hui, Worley, Paul F., Lee, Hey-Kyoung

“…Effective sensory processing depends on sensory experience-dependent metaplasticity, which allows homeostatic maintenance of neural network activity and…”
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Motor, cognitive, and functional declines contribute to a single progressive factor in early HD by Schobel, Scott A, Palermo, Giuseppe, Auinger, Peggy, Long, Jeffrey D, Ma, Shiyang, Khwaja, Omar S, Trundell, Dylan, Cudkowicz, Merit, Hersch, Steven, Sampaio, Cristina, Dorsey, E Ray, Leavitt, Blair R, Kieburtz, Karl D, Sevigny, Jeffrey J, Langbehn, Douglas R, Tabrizi, Sarah J

“…OBJECTIVE:To identify an improved measure of clinical progression in early Huntington disease (HD) using data from prospective observational cohort studies and…”
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Safety and efficacy of pridopidine in patients with Huntington's disease (PRIDE-HD): a phase 2, randomised, placebo-controlled, multicentre, dose-ranging study by Reilmann, Ralf, Grachev, Igor D, Savola, Juha-Matti, Borowsky, Beth, Eyal, Eli, Gross, Nicholas, Langbehn, Douglas, Schubert, Robin, Wickenberg, Anna Teige, Papapetropoulos, Spyros, Squitieri, Ferdinando, Kieburtz, Karl, Landwehrmeyer, G Bernhard, Agarwal, Pinky, Anderson, Karen E, Aziz, Nasir A, Azulay, Jean-Phillippe, Bachoud-Levi, Anne C, Barker, Roger, Bebak, Agnieszka, Beuth, Markus, Biglan, Kevin, Blin, Stephanie, Bonelli, Raphael, Caldwell, Sue, Calvas, Fabienne, Carlos, Jonielyn, Chong, Terrence, Chua, Phyllis, Coleman, Allison, Corey-Bloom, Jody, Cousins, Rebecca, Craufurd, David, De Michele, Giuseppe, Dornhege, Laura, Feigin, Andrew, Gallehawk, Stephanie, Gauteul, Pascale, Gonzales, Carey, Griffith, Jane, Guttman, Mark, Heim, Beatrix, Heller, Hope, Hjermind, Lena, Ivanko, Larry, Jaynes, Jessica, Jenckes, Mollie, Kaminski, Barbara, Kampstra, Anne, Konkel, Agnieszka, Kopishinskaya, Svetlana, Krystkowiak, Pierre, Komati, Suresh K, Lakoning, Stefan, Latipova, Guzal, Leavitt, Blair, Loy, Clement, Madsen, Louise, Marder, Karen, Mason, Sarah, Mendis, Neila, Mendis, Tilak, Norris, Virginia, Olivier, Audrey, Orth, Michael, Owens, Ashley, Panegyres, Peter, Perlman, Susan, Preston, Joy, Puch, Alicja, Rialland, Amandine, Rickards, Hugh, Romoli, Anna M, Ross, Christopher, Rosser, Anne, Rudzinska, Monika, Russo, Cinzina V, Saft, Carsten, Segro, Victoria, Seppi, Klaus, Shannon, Barbara, Shprecher, David, Simonin, Clemence, Skitt, Zara, Soliveri, Paola, Squitieri, Ferdinando, Suski, Valarie, Stepniak, Iwona, Sungmee, Park, Temirbaeva, Sofia, Uhl, Stefanie, Vangsted-Hansen, Christina, Verny, Christophe, Wall, Paola, Walker, Francis, Wasserman, Paula, Witkowski, Grzegorz, Wright, Jan, Zalyalova, Zuleykha, Zielonka, Daniel

“…Previous trials have shown that pridopidine might reduce motor impairment in patients with Huntington's disease. The aim of this study was to ascertain whether…”
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Aging-dependent loss of functional connectivity in a mouse model of Alzheimer's disease and reversal by mGluR5 modulator by Mandino, Francesca, Shen, Xilin, Desrosiers-Grégoire, Gabriel, O'Connor, David, Mukherjee, Bandhan, Owens, Ashley, Qu, An, Onofrey, John, Papademetris, Xenophon, Chakravarty, M Mallar, Strittmatter, Stephen M, Lake, Evelyn M R

“…Amyloid accumulation in Alzheimer's disease (AD) is associated with synaptic damage and altered connectivity in brain networks. While measures of amyloid…”
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A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease by McGarry, Andrew, McDermott, Michael, Kieburtz, Karl, de Blieck, Elisabeth A., Beal, Flint, Marder, Karen, Ross, Christopher, Shoulson, Ira, Gilbert, Peter, Mallonee, William M., Guttman, Mark, Wojcieszek, Joanne, Kumar, Rajeev, LeDoux, Mark S., Jenkins, Mary, Rosas, H. Diana, Nance, Martha, Biglan, Kevin, Como, Peter, Dubinsky, Richard M., Shannon, Kathleen M., OʼSuilleabhain, Padraig, Chou, Kelvin, Walker, Francis, Martin, Wayne, Wheelock, Vicki L., McCusker, Elizabeth, Jankovic, Joseph, Singer, Carlos, Sanchez-Ramos, Juan, Scott, Burton, Suchowersky, Oksana, Factor, Stewart A., Higgins, Donald S., Molho, Eric, Revilla, Fredy, Caviness, John N., Friedman, Joseph H., Perlmutter, Joel S., Feigin, Andrew, Anderson, Karen, Rodriguez, Ramon, McFarland, Nikolaus R., Margolis, Russell L., Farbman, Eric S., Raymond, Lynn A., Suski, Valerie, Kostyk, Sandra, Colcher, Amy, Seeberger, Lauren, Epping, Eric, Esmail, Sherali, Diaz, Nancy, Fung, Wai Lun Alan, Diamond, Alan, Frank, Samuel, Hanna, Philip, Hermanowicz, Neal, Dure, Leon S., Cudkowicz, Merit

“…OBJECTIVE:To test the hypothesis that chronic treatment of early-stage Huntington disease (HD) with high-dose coenzyme Q10 (CoQ) will slow the progressive…”
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High-Throughput Detection of Ligand-Protein Binding Using a SplitLuc Cellular Thermal Shift Assay by Sanchez, Tino W, Owens, Ashley, Martinez, Natalia J, Wallgren, Eric, Simeonov, Anton, Henderson, Mark J

“…The confirmation of a small molecule binding to a protein target can be challenging when switching from biochemical assays to physiologically relevant cellular…”
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A progression in first-grade children's thinking about variable and variable notation in functional relationships by Blanton, Maria, Brizuela, Bárbara M., Gardiner, Angela Murphy, Sawrey, Katie, Newman-Owens, Ashley

“…Recent research suggests that children in elementary grades have some facility with variable and variable notation in ways that warrant closer attention. We…”
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MOTIVATION TO LEARN IN GENERAL EDUCATION PROGRAMS by Glynn, Shawn M., Aultman, Lori Price, Owens, Ashley M.

“…All members of the higher education community share the important goal of fostering college students' motivation to learn. Which contemporary constructs best…”
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A learning trajectory in Kindergarten and first grade students’ thinking of variable and use of variable notation to represent indeterminate quantities by Ventura, Ana Clara, Brizuela, Bárbara M., Blanton, Maria, Sawrey, Katharine, Gardiner, Angela Murphy, Newman-Owens, Ashley

“…•Representing indeterminate quantities is crucial for algebraic thinking.•No child used variable notation in the pre – interview of classroom teaching…”
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Compositional Dependence of Borate Glasses for White Light Emission Studies by Owens, Ashley B

“…Light emitting diodes are energy efficient lighting solutions for commercial and residential applications. They come in two main forms: a single diode with…”
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Children's Use of Variables and Variable Notation to Represent Their Algebraic Ideas by Brizuela, Bárbara M., Blanton, Maria, Sawrey, Katharine, Newman-Owens, Ashley, Murphy Gardiner, Angela

“…In this article, we analyze a first grade classroom episode and individual interviews with students who participated in that classroom event to provide…”
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Membrane microdomains and cAMP compartmentation by Agarwal, Shailesh, Caldwell, Kacie, Owens, Ashley, Singer, Cherie, Nikolaev, Viacheslav, Lohse, Martin, Harvey, Robert

“…Abstract only The role of different membrane domains in the compartmentation of cAMP signaling was investigated using the FRET‐based Epac2‐ camps biosensor…”
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