Search Results - "Owen, Ryan"

Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials by Gevaert, Philippe, Omachi, Theodore A., Corren, Jonathan, Mullol, Joaquim, Han, Joseph, Lee, Stella E., Kaufman, Derrick, Ligueros-Saylan, Monica, Howard, Monet, Zhu, Rui, Owen, Ryan, Wong, Kit, Islam, Lutaf, Bachert, Claus

“…Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by IgE hyperproduction and eosinophilic inflammation. The anti-IgE antibody, omalizumab, has…”
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The Prevalence of Y-chromosome Microdeletions in Oligozoospermic Men: A Systematic Review and Meta-analysis of European and North American Studies by Kohn, Taylor P., Kohn, Jaden R., Owen, Ryan C., Coward, R. Matthew

“…European and North American guidelines recommend Y-chromosome microdeletion (YCM) screening in azoospermic and oligozoospermic men with sperm concentrations of…”
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Multiplex engineering of industrial yeast genomes using CRISPRm by Ryan, Owen W, Cate, Jamie H D

“…Global demand has driven the use of industrial strains of the yeast Saccharomyces cerevisiae for large-scale production of biofuels and renewable chemicals…”
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Genotype to Phenotype: A Complex Problem by Dowell, Robin D, Ryan, Owen, Jansen, An, Cheung, Doris, Agarwala, Sudeep, Danford, Timothy, Bernstein, Douglas A, Rolfe, P. Alexander, Heisler, Lawrence E, Chin, Brian, Nislow, Corey, Giaever, Guri, Phillips, Patrick C, Fink, Gerald R, Gifford, David K, Boone, Charles

“…We generated a high-resolution whole-genome sequence and individually deleted 5100 genes in Σ1278b, a Saccharomyces cerevisiae strain closely related to…”
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Selection of chromosomal DNA libraries using a multiplex CRISPR system by Ryan, Owen W, Skerker, Jeffrey M, Maurer, Matthew J, Li, Xin, Tsai, Jordan C, Poddar, Snigdha, Lee, Michael E, DeLoache, Will, Dueber, John E, Arkin, Adam P, Cate, Jamie H D

“…The directed evolution of biomolecules to improve or change their activity is central to many engineering and synthetic biology efforts. However, selecting…”
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The global response to HIV in men who have sex with men by Beyrer, Chris, Prof, Baral, Stefan D, MD, Collins, Chris, MPP, Richardson, Eugene T, MD, Sullivan, Patrick S, Prof, Sanchez, Jorge, MD, Trapence, Gift, BA, Katabira, Elly, MD, Kazatchkine, Michel, Prof, Ryan, Owen, MPH, Wirtz, Andrea L, PhD, Mayer, Kenneth H, Prof

“…Summary Gay, bisexual, and other men who have sex with men (MSM) continue to have disproportionately high burdens of HIV infection in countries of low, middle,…”
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Global Gene Deletion Analysis Exploring Yeast Filamentous Growth by Ryan, Owen, Shapiro, Rebecca S., Kurat, Christoph F., Mayhew, David, Baryshnikova, Anastasia, Chin, Brian, Lin, Zhen-Yuan, Cox, Michael J., Vizeacoumar, Frederick, Cheung, Doris, Bahr, Sondra, Tsui, Kyle, Tebbji, Faiza, Sellam, Adnane, Istel, Fabian, Schwarzmüller, Tobias, Reynolds, Todd B., Kuchler, Karl, Gifford, David K., Whiteway, Malcolm, Giaever, Guri, Nislow, Corey, Costanzo, Michael, Gingras, Anne-Claude, Mitra, Robi David, Andrews, Brenda, Fink, Gerald R., Cowan, Leah E., Boone, Charles

“…The dimorphic switch from a single-cell budding yeast to a filamentous form enables Saccharomyces cerevisiae to forage for nutrients and the opportunistic…”
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Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action by Shu, Yan, Sheardown, Steven A, Brown, Chaline, Owen, Ryan P, Zhang, Shuzhong, Castro, Richard A, Ianculescu, Alexandra G, Yue, Lin, Lo, Joan C, Burchard, Esteban G, Brett, Claire M, Giacomini, Kathleen M

“…Metformin is among the most widely prescribed drugs for the treatment of type 2 diabetes. Organic cation transporter 1 (OCT1) plays a role in the hepatic…”
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Management and counseling of the male with advanced paternal age by Jennings, Michael O., M.D, Owen, Ryan C., M.D, Keefe, David, M.D, Kim, Edward D., M.D

“…Increasing percentages of children are being born to older fathers. This has resulted in concerns about the potential adverse effects of advanced paternal age…”
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The significance of clinical practice guidelines on adult varicocele detection and management by Shridharani, Anand, Owen, Ryan C, Elkelany, Osama O, Kim, Edward D

“…Varicoceles are the most common correctable etiology of male factor infertility. However, the detection and management of varicoceles have not been…”
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CRISPR-Cas9 Genome Engineering in Saccharomyces cerevisiae Cells by Ryan, Owen W, Poddar, Snigdha, Cate, Jamie H D

“…This protocol describes a method for CRISPR-Cas9-mediated genome editing that results in scarless and marker-free integrations of DNA into Saccharomyces…”
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Inhaled JAK inhibitor GDC-0214 reduces exhaled nitric oxide in patients with mild asthma: A randomized, controlled, proof-of-activity trial by Braithwaite, Irene E., Cai, Fang, Tom, Jennifer A., Galanter, Joshua M., Owen, Ryan P., Zhu, Rui, Williams, Mathew, McGregor, Anna G., Eliahu, Avi, Durk, Matthew R., Dengler, Hart S., Zak, Mark, Kenny, Jane R., Wilson, Maria E., Beasley, Richard, Chen, Hubert

“…The Janus kinase (JAK) pathway mediates the activity of many asthma-relevant cytokines, including IL-4 and IL-13. GDC-0214 is a potent, inhaled, small-molecule…”
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Engineering Kluyveromyces marxianus as a Robust Synthetic Biology Platform Host by Cernak, Paul, Estrela, Raissa, Poddar, Snigdha, Skerker, Jeffrey M, Cheng, Ya-Fang, Carlson, Annika K, Chen, Berling, Glynn, Victoria M, Furlan, Monique, Ryan, Owen W, Donnelly, Marie K, Arkin, Adam P, Taylor, John W, Cate, Jamie H D

“…Throughout history, the yeast has played a central role in human society due to its use in food production and more recently as a major industrial and model…”
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The International AIDS Society—Lancet Commission on the future of the HIV response and global health by Beyrer, Chris, Das, Pamela, Horton, Richard, Ryan, Owen, Bekker, Linda-Gail

“…The Commission will address epidemic scenarios as diverse as the expanding epidemics among people who inject drugs in Russia and Ukraine,5 the high burden…”
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A nontraditional presentation and treatment for emphysematous cystitis by Becker, Benjamin, George, Asher, Owen, Ryan

“…Emphysematous cystitis (EC) is a bladder pathology typically resulting from gas-producing bacterial infections. Risk factors include female gender, age greater…”
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Reply to Alberto Ferlin’s Letter to the Editor, re: Taylor P. Kohn, Jaden R. Kohn, Ryan C. Owen, R. Matthew Coward. The Prevalence of Y-chromosome Microdeletions in Oligozoospermic Men: A Systematic Review, Meta-analysis of European, North American Studies. Eur Urol 2019, 76:626–36. Indication for Y Chromosome Microdeletion Analysis in Infertile Men Should Not be, Based Merely on Sperm Concentration: Shared Decision-Making and Reconsideration of Thresholds for Genetic Testing of Men with Severe by Kohn, Taylor P., Kohn, Jaden R., Owen, Ryan C., Matthew Coward, R.

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VKORC1 Pharmacogenomics Summary by Owen, Ryan P, Gong, Li, Sagreiya, Hersh, Klein, Teri E, Altman, Russ B

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The Paf1 Complex Is Required for Histone H3 Methylation by COMPASS and Dot1p: Linking Transcriptional Elongation to Histone Methylation by Krogan, Nevan J., Dover, Jim, Wood, Adam, Schneider, Jessica, Heidt, Jonathan, Boateng, Marry Ann, Dean, Kimberly, Ryan, Owen W., Golshani, Ashkan, Johnston, Mark, Greenblatt, Jack F., Shilatifard, Ali

“…Methylation of histone proteins is one of their many modifications that affect chromatin structure and regulate gene expression. Methylation of histone H3 on…”
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Best practice in the diagnosis and treatment of varicocele in children and adolescents by Macey, Matthew R., Owen, Ryan C., Ross, Sherry S., Coward, R. Matthew

“…A varicocele is an abnormal dilation of the pampiniform plexus of veins in the scrotum which begins at puberty in approximately 15% of males. Although common…”
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First-in-human phase 1 trial evaluating safety, pharmacokinetics, and pharmacodynamics of NLRP3 inflammasome inhibitor, GDC-2394, in healthy volunteers by Tang, Fei, Kunder, Rebecca, Chu, Tom, Hains, Avis, Nguyen, Allen, McBride, Jacqueline M, Zhong, Yu, Santagostino, Sara, Wilson, Maria, Trenchak, Abigail, Chen, Liuxi, Ly, Justin, Moein, Anita, Lewin-Koh, Nicholas, Raghavan, Vibha, Osaghae, Uyi, Wynne, Chris, Owen, Ryan, Place, David

“…Inappropriate and chronic activation of the cytosolic NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) inflammasome, a key component of innate immunity,…”
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