Search Results - "Owen, Maurice C."

Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes by Marks, Edward C A, Wilkinson, Tom M, Frampton, Chris M, Skelton, Lorraine, Pilbrow, Anna P, Yandle, Tim G, Pemberton, Chris J, Doughty, Robert N, Whalley, Gillian A, Ellis, Chris J, Troughton, Richard W, Owen, Maurice C, Pattinson, Neil R, Cameron, Vicky A, Richards, A Mark, Gieseg, Steven P, Palmer, Barry R

“…Development of collateral circulation in coronary artery disease is cardio-protective. A key process in forming new blood vessels is attraction to occluded…”
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Molecular basis of a redox switch: molecular dynamics simulations and surface plasmon resonance provide insight into reduced and oxidised angiotensinogen by Crowther, Jennifer M, Gilmour, Letitia H, Porebski, Benjamin T, Heath, Sarah G, Pattinson, Neil R, Owen, Maurice C, Fredericks, Rayleen, Buckle, Ashley M, Fee, Conan J, Göbl, Christoph, Dobson, Renwick C J

“…Angiotensinogen fine-tunes the tightly controlled activity of the renin-angiotensin system by modulating the release of angiotensin peptides that control blood…”
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Novel haemoglobin mutation (α127Lys→Glu) increases oxygen affinity and has a minor effect on haptoglobin binding by Brennan, Stephen O., Pullon, Beverley, Owen, Maurice C., Brittain, Thomas

“…To determine if a new haemoglobin (Hb) variant was the underlying cause of erythrocytosis in a subject with a high apparent HbA1c. Haemolysate was analysed by…”
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Novel hemoglobin α chain elongation resulting from a 15-residue insertion and tandem duplication of the F helix by Brennan, Stephen O, Owen, Maurice C, Chan, Tim, Ruskova, Anna

“…To determine the cause of an unusual hemoglobin pattern with two novel components eluting after HbA2 on cation exchange HPLC. This variant was detected during…”
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Convenient high-resolution isoelectric focusing (IEF) method for the separation of alpha1-proteinase inhibitor (A1PI) isoforms in A1PI concentrates by Weber, Alfred, Engelmaier, Andrea, Owen, Maurice C., Schwarz, Hans-Peter, Turecek, Peter L.

“…Currently, high-resolution separation of A1PI is done in highly specialized laboratories using gels made in-house. This paper presents a high-resolution method…”
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Plakalbumin, α1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis by CARRELL, R. W, OWEN, M. C

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Structure and variation of human α1–antitrypsin by Carrell, Robin W., Jeppsson, Jan-Olof, Laurell, Carl-Bertil, Brennan, Stephen O., Owen, Maurice C., Vaughan, Lloyd, Boswell, D. Ross

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Conformational lability of vitronectin: induction of an antigenic change by alpha-thrombin-serpin complexes and by proteolytically modified thrombin by Tomasini, Bianca R, Mosher, Deane F, Owen, Maurice C, Fenton, John W

“…We previously showed that the alpha-thrombin-antithrombin III complex causes antigenic change in vitronectin as monitored by the monoclonal anti-vitronectin…”
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Plakalbumin, α 1 -antitrypsin, antithrombin and the mechanism of inflammatory thrombosis by Carrell, Robin W, Owen, Maurice C

“…An old puzzle in protein biochemistry concerns the ready conversion of ovalbumin, by proteolysis, to the much more stable derivative, plakalbumin. Ovalbumin is…”
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Structure and variation of human α 1 -antitrypsin by Carrell, Robin W, Jeppsson, Jan-Olof, Laurell, Carl-Bertil, Brennan, Stephen O, Owen, Maurice C, Vaughan, Lloyd, Boswell, D. Ross

“…The sequence of alpha 1-antitrypsin is in keeping with its role as a tissue scavenger of leukocyte elastase. Two abnormal variants commonly present in…”
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Antithrombin Glasgow, 393 arg to his: A P 1 reactive site variant with increased heparin affinity but no thrombin inhibitory activity by Owen, Maurice C., Beresford, Charles H., Carrell, Robin W.

“…Antithrombin Glasgow is a hereditary abnormal antithrombin that has lost thrombin inhibitory activity. It was isolated from the plasma of a 41-year-old male…”
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P1 variant antithrombins Glasgow (393 Arg to His) and Pescara (393 Arg to Pro) have increased heparin affinity and are resistant to catalytic cleavage by elastase Implications for the heparin activation mechanism by Owen, Maurice C., George, Peter M., Lane, David A., Boswell, D.Ross

“…The heparin affinity of normal and two P1 variants of antithrombin-III (AT) was studied by gradient elution with NaCl in Tris buffer on heparin-Sepharose. At…”
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Antithrombin Glasgow, 393 arg to his: A P1 reactive site variant with increased heparin affinity but no thrombin inhibitory activity by Owen, Maurice C., Beresford, Charles H., Carrell, Robin W.

“…Antithrombin Glasgow is a hereditary abnormal antithrombin that has lost thrombin inhibitory activity. It was isolated from the plasma of a 41‐year‐old male…”
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A competitive ELISA for lipoprotein(a) by Yeo, K H, Walmsley, T A, Owen, M C, George, P M

“…A competitive ELISA for lipoprotein(a) (Lp(a)) is described. The method uses a commercially available polyclonal anti-Lp(a) antibody and an IgG…”
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Circulating proalbumin associated with a variant proteinase inhibitor by Brennan, S O, Owen, M C, Boswell, D R, Lewis, J H, Carrell, R W

“…The unique finding of normal proalbumin in human plasma provides an insight into the mechanism of propeptide cleavage. Proalbumin, present as 1-5% of the total…”
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Immunoadsorbent purification of antithrombin: active form and inactive variants by Molloy, C, Owen, M C, Boswell, D R

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α-1-Antitrypsin: Sequence of the Z variant tryptic peptide by Owen, Maurice C., Carrell, Robin W.

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α-1-Antitrypsin: Structural relationships of the substitutions of the S and Z variants by Owen, Maurice C., Lorier, Michel, Carrell, Robin W.

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Antithrombin III by Beresford, C H, Owen, M C

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Active site of alpha 1-antitrypsin: homologous site in antithrombin-III by Carrell, R W, Boswell, D R, Brennan, S O, Owen, M C

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