Search Results - "Owen, Celeste"

V‐ATPases Containing a3 Subunit Play a Direct Role in Enamel Development in Mice by Johnson, Lisa, Ganss, Bernhard, Wang, Andrew, Zirngibl, Ralph A., Johnson, Danielle E., Owen, Celeste, Bradley, Grace, Voronov, Irina

“…ABSTRACT Vacuolar H+‐ATPases (V‐ATPases) are ubiquitous multisubunit proton pumps responsible for organellar pH maintenance. Mutations in the a3 subunit of…”
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Activity-independent targeting of mTOR to lysosomes in primary osteoclasts by Wang, Andrew, Carraro-Lacroix, Luciene R., Owen, Celeste, Gao, Bowen, Corey, Paul N., Tyrrell, Pascal, Brumell, John H., Voronov, Irina

“…Mammalian target of rapamycin (mTOR) is activated by numerous stimuli, including amino acids and growth factors. This kinase is part of the mTOR complex 1…”
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Lysosomal pH Plays a Key Role in Regulation of mTOR Activity in Osteoclasts by Hu, Yingwei, Carraro-Lacroix, Luciene R., Wang, Andrew, Owen, Celeste, Bajenova, Elena, Corey, Paul N., Brumell, John H., Voronov, Irina

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The R740S mutation in the V‐ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation, and decreases in vitro osteoclastogenesis by Voronov, Irina, Ochotny, Noelle, Jaumouillé, Valentin, Owen, Celeste, Manolson, Morris F, Aubin, Jane E

“…Vacuolar H+‐ATPase (V‐ATPase), a multisubunit enzyme located at the ruffled border and in lysosomes of osteoclasts, is necessary for bone resorption. We…”
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Longitudinal Analysis of Mesenchymal Progenitors and Bone Quality in the Stem Cell Antigen‐1–Null Osteoporotic Mouse by Holmes, Christina, Khan, Tayyab S, Owen, Celeste, Ciliberti, Nadia, Grynpas, Marc D, Stanford, William L

“…We performed a longitudinal analysis of bone quality in Sca‐1–null mice. A tight temporal, site‐specific association between Sca‐1–deficient BMD deficiency and…”
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Lysosomal pH Plays a Key Role in Regulation of mTOR Activity in Osteoclasts by Hu, Yingwei, Carraro‐Lacroix, Luciene R., Wang, Andrew, Owen, Celeste, Bajenova, Elena, Corey, Paul N., Brumell, John H., Voronov, Irina

“…ABSTRACT Mammalian target of rapamycin (mTOR) is a serine/threonine kinase involved in the regulation of cell growth. It has been shown to play an important…”
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The R740S mutation in the V-ATPase a3 subunit results in osteoclast apoptosis and defective early-stage autophagy by Ochotny, Noelle, Voronov, Irina, Owen, Celeste, Aubin, Jane E., Manolson, Morris F.

“…ABSTRACT Vacuolar‐type H+‐ATPases (V‐ATPases) are located in lysosomes and at the ruffled border in osteoclasts. We showed previously that the R740S mutation…”
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V‐ATPases Containing a 3 Subunit Play a Direct Role in Enamel Development in Mice by Johnson, Lisa, Ganss, Bernhard, Wang, Andrew, Zirngibl, Ralph A., Johnson, Danielle E., Owen, Celeste, Bradley, Grace, Voronov, Irina

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Lysosomal pH Plays a Key Role in Regulation of mTOR Activity in Osteoclasts: Lysosomal pH Plays a Key Role in Regulation by Hu, Yingwei, Carraro-Lacroix, Luciene R., Wang, Andrew, Owen, Celeste, Bajenova, Elena, Corey, Paul N., Brumell, John H., Voronov, Irina

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Genome-wide screening of mouse knockouts reveals novel genes required for normal integumentary and oculocutaneous structure and function by Moore, Bret A., Flenniken, Ann M., Clary, Dave, Moshiri, Ata S., Nutter, Lauryl M. J., Berberovic, Zorana, Owen, Celeste, Newbigging, Susan, Adissu, Hibret, Eskandarian, Mohammad, McKerlie, Colin, Thomasy, Sara M., Lloyd, K. C. Kent, Murphy, Christopher J., Moshiri, Ala

“…Oculocutaneous syndromes are often due to mutations in single genes. In some cases, mouse models for these diseases exist in spontaneously occurring mutations,…”
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The R740 S mutation in the V‐ ATP ase a3 subunit results in osteoclast apoptosis and defective early‐stage autophagy by Ochotny, Noelle, Voronov, Irina, Owen, Celeste, Aubin, Jane E., Manolson, Morris F.

“…Vacuolar-type H super(+)-ATPases (V-ATPases) are located in lysosomes and at the ruffled border in osteoclasts. We showed previously that the R740S mutation is…”
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A novel Phex mutation in a new mouse model of hypophosphatemic rickets by Owen, Celeste, Chen, Frieda, Flenniken, Ann M., Osborne, Lucy R., Ichikawa, Shoji, Adamson, S. Lee, Rossant, Janet, Aubin, Jane E.

“…X‐linked hypophosphatemic rickets (XLH) is a dominantly inherited disease characterized by renal phosphate wasting, aberrant vitamin D metabolism, and…”
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The V–ATPase a3 subunit mutation R740S is dominant negative and results in osteopetrosis in mice by Ochotny, Noelle, Flenniken, Ann M, Owen, Celeste, Voronov, Irina, Zirngibl, Ralph A, Osborne, Lucy R, Henderson, Janet E, Adamson, S Lee, Rossant, Janet, Manolson, Morris F, Aubin, Jane E

“…A mouse founder with high bone mineral density and an osteopetrotic phenotype was identified in an N‐ethyl‐N‐nitrosourea (ENU) screen. It was found to carry a…”
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Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts by Moore, Bret A, Leonard, Brian C, Sebbag, Lionel, Edwards, Sydney G, Cooper, Ann, Imai, Denise M, Straiton, Ewan, Santos, Luis, Reilly, Christopher, Griffey, Stephen M, Bower, Lynette, Clary, David, Mason, Jeremy, Roux, Michel J, Meziane, Hamid, Herault, Yann, McKerlie, Colin, Flenniken, Ann M, Nutter, Lauryl M J, Berberovic, Zorana, Owen, Celeste, Newbigging, Susan, Adissu, Hibret, Eskandarian, Mohammed, Hsu, Chih-Wei, Kalaga, Sowmya, Udensi, Uchechukwu, Asomugha, Chinwe, Bohat, Ritu, Gallegos, Juan J, Seavitt, John R, Heaney, Jason D, Beaudet, Arthur L, Dickinson, Mary E, Justice, Monica J, Philip, Vivek, Kumar, Vivek, Svenson, Karen L, Braun, Robert E, Wells, Sara, Cater, Heather, Stewart, Michelle, Clementson-Mobbs, Sharon, Joynson, Russell, Gao, Xiang, Suzuki, Tomohiro, Wakana, Shigeharu, Smedley, Damian, Seong, J K, Tocchini-Valentini, Glauco, Moore, Mark, Fletcher, Colin, Karp, Natasha, Ramirez-Solis, Ramiro, White, Jacqueline K, de Angelis, Martin Hrabe, Wurst, Wolfgang, Thomasy, Sara M, Flicek, Paul, Parkinson, Helen, Brown, Steve D M, Meehan, Terrence F, Nishina, Patsy M, Murray, Stephen A, Krebs, Mark P, Mallon, Ann-Marie, Kent Lloyd, K C, Murphy, Christopher J, Moshiri, Ala

“…[This corrects the article DOI: 10.1038/s42003-018-0226-0.]…”
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The Role of Gja1 Gap Junctions in the Bone Marrow Niche by Anderson, Nicole M., Zirngibi, Ralph, Chen, Frieda, Owen, Celeste, Zitano, Lia, Lau, Esther, Aubin, Jane, Stanford, William

“…The interplay between the stroma and hematopoietic progenitors within the bone marrow niche is critical for the homeostatic regulation of both mesenchymal and…”
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