Search Results - "Oweida, Ayman J"

Overcoming Resistance to Combination Radiation-Immunotherapy: A Focus on Contributing Pathways Within the Tumor Microenvironment by Darragh, Laurel B, Oweida, Ayman J, Karam, Sana D

“…Radiation therapy has been used for many years to treat tumors based on its DNA-damage-mediated ability to kill cells. More recently, RT has been shown to…”
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Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2 by Hatmal, Ma'mon M, Alshaer, Walhan, Al-Hatamleh, Mohammad A I, Hatmal, Malik, Smadi, Othman, Taha, Mutasem O, Oweida, Ayman J, Boer, Jennifer C, Mohamud, Rohimah, Plebanski, Magdalena

“…The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has recently emerged in China and caused a disease called coronavirus disease 2019 (COVID-19)…”
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Toll-Like Receptors and the Response to Radiotherapy in Solid Tumors: Challenges and Opportunities by Haroun, Ryma, Naasri, Sahar, Oweida, Ayman J

“…Toll-like receptors (TLRs) are indispensable for the activation, maintenance and halting of immune responses. TLRs can mediate inflammation by recognizing…”
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Gingerol acts as a potent radiosensitizer in head and neck squamous cell carcinoma by Rutihinda, Cleopatra, Haroun, Ryma, Ordonez, Juan Pablo, Mohssine, Saad, Oweida, Huda, Sharma, Muskaan, Fares, Mohamed, Ruiz-Dominguez, Nancy, Pacheco, Maria Fernanda Meza, Naasri, Sahar, Saidi, Nour Elhouda, Oweida, Ayman J.

“…Treatment options for advanced head and neck squamous cell carcinoma (HNSCC) are limited and often cause severe toxicity and debilitating long-term impacts…”
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Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis by Knitz, Michael W, Bickett, Thomas E, Darragh, Laurel B, Oweida, Ayman J, Bhatia, Shilpa, Van Court, Benjamin, Bhuvane, Shiv, Piper, Miles, Gadwa, Jacob, Mueller, Adam C, Nguyen, Diemmy, Nangia, Varuna, Osborne, Douglas G, Bai, Xiyuan, Ferrara, Sarah E, Boss, Mary-Keara, Goodspeed, Andrew, Burchill, Matthew A, Tamburini, Beth A Jirón, Chan, Edward D, Pickering, Curtis R, Clambey, Eric T, Karam, Sana D

“…BackgroundNumerous trials combining radiation therapy (RT) and immunotherapy in head and neck squamous cell carcinoma (HNSCC) are failing. Using preclinical…”
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STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer by Oweida, Ayman J, Darragh, Laurel, Phan, Andy, Binder, David, Bhatia, Shilpa, Mueller, Adam, Court, Benjamin Van, Milner, Dallin, Raben, David, Woessner, Richard, Heasley, Lynn, Nemenoff, Raphael, Clambey, Eric, Karam, Sana D

“…Abstract Background Radioresistance represents a major problem in the treatment of head and neck cancer (HNC) patients. To improve response, understanding…”
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Inhibition of the CCR6-CCL20 axis prevents regulatory T cell recruitment and sensitizes head and neck squamous cell carcinoma to radiation therapy by Rutihinda, Cleopatra, Haroun, Ryma, Saidi, Nour Elhouda, Ordoñez, Juan Pablo, Naasri, Sahar, Lévesque, Dominique, Boisvert, François-Michel, Fortier, Pierre-Hugues, Belzile, Mathieu, Fradet, Laurent, Hubert-Tremblay, Vincent, Turgeon, Guy Anne, Wang, Chang Shu, Delage, Patrick, Rousseau, Étienne, Paquette, Benoît, Oweida, Ayman J.

“…Background  Radioresistance of HNSCCs remains a major challenge for effective tumor control. Combined radiotherapy (RT) and immunotherapy (IT) treatment…”
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PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models by Hernandez, Ariel L, Young, Christian D, Bian, Li, Weigel, Kelsey, Nolan, Kyle, Frederick, Barbara, Han, Gangwen, He, Guanting, Devon Trahan, G, Rudolph, Michael C, Jones, Kenneth L, Oweida, Ayman J, Karam, Sana D, Raben, David, Wang, Xiao-Jing

“…loss causes genomic instability and the initiation/progression of head and neck squamous cell carcinoma (HNSCC). Here, we study whether loss sensitizes HNSCCs…”
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Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer by Mueller, Adam C, Piper, Miles, Goodspeed, Andrew, Bhuvane, Shiv, Williams, Jason S, Bhatia, Shilpa, Phan, Andy V, Van Court, Benjamin, Zolman, Kathryn L, Peña, Brisa, Oweida, Ayman J, Zakem, Sara, Meguid, Cheryl, Knitz, Michael W, Darragh, Laurel, Bickett, Thomas E, Gadwa, Jacob, Mestroni, Luisa, Taylor, Matthew R G, Jordan, Kimberly R, Dempsey, Peter, Lucia, M Scott, McCarter, Martin D, Del Chiaro, Marco, Messersmith, Wells A, Schulick, Richard D, Goodman, Karyn A, Gough, Michael J, Greene, Casey S, Costello, James C, Neto, Antonio Galveo, Lagares, David, Hansen, Kirk C, Van Bokhoven, Adrie, Karam, Sana D

“…Stromal fibrosis activates prosurvival and proepithelial-to-mesenchymal transition (EMT) pathways in pancreatic ductal adenocarcinoma (PDAC). In patient tumors…”
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Response to radiotherapy in pancreatic ductal adenocarcinoma is enhanced by inhibition of myeloid-derived suppressor cells using STAT3 anti-sense oligonucleotide by Oweida, Ayman J., Mueller, Adam C., Piper, Miles, Milner, Dallin, Van Court, Benjamin, Bhatia, Shilpa, Phan, Andy, Bickett, Thomas, Jordan, Kimberly, Proia, Theresa, Schulick, Richard, Messersmith, Wells A., Del Chiaro, Marco, Clambey, Eric, Gough, Michael J., Williams, Jason, Hansen, Kirk, Goodman, Karyn, Karam, Sana D.

“…Pancreatic ductal adenocarcinoma (PDAC) has a heterogeneous tumor microenvironment (TME) comprised of myeloid-derived suppressor cells (MDSCs),…”
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865 Combining radiotherapy with novel TLR-based immunotherapy for improved tumor control in lung cancer by Haroun, Ryma, Ordoñez, Juan Pablo, Oweida, Ayman J

“…BackgroundMost advanced non-small cell lung cancer (NSCLC) patients will receive radiotherapy (RT) during the course of their treatment. However, response to…”
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A comparison of overall survival for patients with T4 larynx cancer treated with surgical versus organ‐preservation approaches: A National Cancer Data Base analysis by Stokes, William A., Jones, Bernard L., Bhatia, Shilpa, Oweida, Ayman J., Bowles, Daniel W., Raben, David, Goddard, Julie A., McDermott, Jessica D., Karam, Sana D.

“…BACKGROUND Although laryngectomy is the treatment of choice for patients with T4 larynx cancer, many patients are unable or unwilling to undergo laryngectomy…”
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Dichotomous effects of cellular expression of STAT3 on tumor growth of HNSCC by Bickett, Thomas E., Knitz, Michael W., Piper, Miles, Oweida, Ayman J., Gadwa, Jacob, Darragh, Laurel B., Nguyen, Diemmy, Bhatia, Shilpa, Bhuvane, Shiv, Phan, Andy V., Van Court, Benjamin, Corbo, Sophia, Pham, Tiffany, Dent, Alexander L., Lenz, Laurel, Karam, Sana D.

“…STAT3 signaling has been shown to regulate cellular function and cytokine production in the tumor microenvironment (TME). Within the head and neck squamous…”
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Impact of immunotherapy among patients with melanoma brain metastases managed with radiotherapy by Stokes, William A., Binder, David C., Jones, Bernard L., Oweida, Ayman J., Liu, Arthur K., Rusthoven, Chad G., Karam, Sana D.

“…Patients with melanoma brain metastases (MBM) have been excluded from trials evaluating immunotherapy in melanoma. As such, immunotherapy's role in MBM is…”
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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment by Oweida, Ayman J, Bhatia, Shilpa, Van Court, Benjamin, Darragh, Laurel, Serkova, Natalie, Karam, Sana D

“…Head and neck squamous cell carcinoma (HNSCC) is a debilitating and deadly disease with a high prevalence of recurrence and treatment failure. To develop…”
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Iron-oxide labeling of hematogenous macrophages in a model of experimental autoimmune encephalomyelitis and the contribution to signal loss in fast imaging employing steady state acquisition (FIESTA) images by Oweida, Ayman J., Dunn, Elizabeth A., Karlik, Stephen J., Dekaban, Gregory A., Foster, Paula J.

“…Purpose To determine the contribution of blood‐derived macrophages to the signal loss observed in MR images of inflammatory lesions in experimental autoimmune…”
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Cellular imaging at 1.5 T: detecting cells in neuroinflammation using active labeling with superparamagnetic iron oxide by Oweida, Ayman J, Dunn, Elizabeth A, Foster, Paula J

“…The ability to visualize cell infiltration in experimental auto-immune encephalomyelitis (EAE), a well-known animal model for multiple sclerosis in humans, was…”
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Cellular Imaging at 1.5 T: Detecting Cells in Neuroinflammation using Active Labeling with Superparamagnetic Iron Oxide by Oweida, Ayman J., Dunn, Elizabeth A., Foster, Paula J.

“…The ability to visualize cell infiltration in experimental autoimmune encephalomyelitis (EAE), a well-known animal model for multiple sclerosis in humans, was…”
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Abstract 4168: Radioresistant anaplastic thyroid cancers display a unique gene signature and respond to hypofractionated radiotherapy by Oweida, Ayman J., Phan, Andy, Vancourt, Benjamin, Robin, Tyler, Raben, David, Haugen, Bryan, Pozdeyev, Nikita, Schweppe, Rebecca, Karam, Sana D.

“…Abstract Purpose: Patients diagnosed with anaplastic thyroid (ATC) cancer display heterogeneous tumor responses to radiation therapy. It remains unclear how…”
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Abstract 2043: The role of CCL20 in response to radiation in head and neck squamous cell carcinomas by Rutihinda, Cleopatra, Oweida, Ayman J., Delage, Patrick, Moreau, Léanie, Chelighem, Safia, Saidi, Nour Elhouda

“…Abstract Background: Radioresistance is responsible for most cases of tumor progression and recurrence in head and neck squamous cell carcinomas (HNSCC)…”
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