Search Results - "Owada, Satoshi"

Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells by Endo, Hitoshi, Owada, Satoshi, Inagaki, Yutaka, Shida, Yukari, Tatemichi, Masayuki

“…Cancer cells utilise the glycolytic pathway to support their rapid growth and proliferation. Since cells in most solid tumours are subjected to severe…”
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Epidermal Growth Factor Receptor (EGFR) Signaling Regulates Global Metabolic Pathways in EGFR-mutated Lung Adenocarcinoma by Makinoshima, Hideki, Takita, Masahiro, Matsumoto, Shingo, Yagishita, Atsushi, Owada, Satoshi, Esumi, Hiroyasu, Tsuchihara, Katsuya

“…Genetic mutations in tumor cells cause several unique metabolic phenotypes that are critical for cancer cell proliferation. Mutations in the tyrosine kinase…”
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Metabolic reprogramming sustains cancer cell survival following extracellular matrix detachment by Endo, Hitoshi, Owada, Satoshi, Inagaki, Yutaka, Shida, Yukari, Tatemichi, Masayuki

“…Epithelial cells require attachment to a support, such as the extracellular matrix, for survival. During cancer progression and metastasis, cancerous…”
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Branched-chain amino acids govern the high learning ability phenotype in Tokai high avoider (THA) rats by Shida, Yukari, Endo, Hitoshi, Owada, Satoshi, Inagaki, Yutaka, Sumiyoshi, Hideaki, Kamiya, Akihide, Eto, Tomoo, Tatemichi, Masayuki

“…To fully understand the mechanisms governing learning and memory, animal models with minor interindividual variability and higher cognitive function are…”
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A nationwide cross-sectional survey on hepatitis B and C screening among workers in Japan by Tatemichi, Masayuki, Furuya, Hiroyuki, Nagahama, Satsue, Takaya, Norihide, Shida, Yukari, Fukai, Kota, Owada, Satoshi, Endo, Hitoshi, Kinoue, Takaaki, Korenaga, Masaaki

“…In Japan, there is no publicly funded screening for hepatitis B virus (HBV) and hepatitis C virus (HCV) infections (using HBs antigen and HCV antibody,…”
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Evaluation of Erastin as a Therapeutic Agent Under Hypoxic Conditions in Pancreatic Cancer Cells by Owada, Satoshi, Endo, Hitoshi, Shida, Yukari, Kinoue, Takaaki, Furuya, Hiroyuki, Tatemichi, Masayuki

“…Background/Aim: In pancreatic cancer tissues, hypoxic areas exist due to poor blood flow. Attenuation of the pharmacological efficacy of existing anticancer…”
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Critical role of H2O2 generated by NOX4 during cellular response under glucose deprivation by Owada, Satoshi, Shimoda, Yuko, Tsuchihara, Katsuya, Esumi, Hiroyasu

“…Glucose is the most efficient energy source, and various cancer cells depend on glycolysis for energy production. For maintenance of survival and…”
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Increased Incidence of Visual Field Abnormalities as Determined by Frequency Doubling Technology Perimetry in High Computer Users Among Japanese Workers: A Retrospective Cohort Study by Nakano, Tadashi, Hayashi, Takeshi, Nakagawa, Toru, Honda, Toru, Owada, Satoshi, Endo, Hitoshi, Tatemichi, Masayuki

“…Background: This retrospective cohort study primarily aimed to investigate the possible association of computer use with visual field abnormalities (VFA) among…”
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The intrauterine environment affects learning ability of Tokai high avoider rat offspring derived using cryopreservation and embryo transfer-mediated reproduction by Endo, Hitoshi, Eto, Tomoo, Yoshii, Fumihito, Owada, Satoshi, Watanabe, Tetsu, Tatemichi, Masayuki, Kimura, Minoru

“…Embryo transfer (ET) to recipient female animals is a useful technique in biological and experimental animal studies. While cryopreservation of two-cell stage…”
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Change in plasma lactate concentration during arctigenin administration in a phase I clinical trial in patients with gemcitabine-refractory pancreatic cancer by Fujioka, Rumi, Mochizuki, Nobuo, Ikeda, Masafumi, Sato, Akihiro, Nomura, Shogo, Owada, Satoshi, Yomoda, Satoshi, Tsuchihara, Katsuya, Kishino, Satoshi, Esumi, Hiroyasu

“…Arctigenin is evaluated for antitumor efficacy in patients with pancreatic cancer. It has an inhibitory activity on mitochondrial complex I.Therefore, plasma…”
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Applicability of automatic spectral domain optical coherence tomography for glaucoma mass screening by Nakano, Tadashi, Hayashi, Takeshi, Nakagawa, Toru, Honda, Toru, Owada, Satoshi, Endo, Hitoshi, Tatemichi, Masayuki

“…To perform a preliminary evaluation of the applicability of automatic spectral domain optical coherence tomography (ASD-OCT) for glaucoma mass screening in a…”
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Therapeutic strategies targeting cancer--specific metabolism by Makinoshima, Hideki, Owada, Satoshi, Esumi, Hiroyasu

“…Basic, clinical and translational metabolic researches in cancer area have been extensively tried to discover and develop novel cancer metabolism drugs. Since…”
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Setanaxib as a Potent Hypoxia-specific Therapeutic Agent Against Liver Cancer by Owada, Satoshi, Endo, Hitoshi, Okada, Chisa, Yoshida, Kazuhiro, Shida, Yukari, Tatemichi, Masayuki

“…Background/Aim: Liver cancer has extremely poor prognosis. The cancerous tissues contain hypoxic regions, and the available drugs are poorly effective in…”
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An Adaptation System to Avoid Apoptosis via Autophagy Under Hypoxic Conditions in Pancreatic Cancer Cells by Owada, Satoshi, Ito, Kanako, Endo, Hitoshi, Shida, Yukari, Okada, Chisa, Nezu, Takahiro, Tatemichi, Masayuki

“…Pancreatic cancer tissue is a hypoxic environment resistant to anticancer drugs. This study examined the role of autophagy as a response to hypoxic stress in…”
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Autophagy‑mediated adaptation of hepatocellular carcinoma cells to hypoxia‑mimicking conditions constitutes an attractive therapeutic target by Owada, Satoshi, Endo, Hitoshi, Shida, Yukari, Okada, Chisa, Ito, Kanako, Nezu, Takahiro, Tatemichi, Masayuki

“…Hepatocellular carcinoma has extremely poor prognosis. In cancerous liver tissues, aberrant proliferation of cancer cells leads to the creation of an area…”
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Critical Role of H.sub.2O.sub.2 Generated by NOX4 during Cellular Response under Glucose Deprivation by Owada, Satoshi, Shimoda, Yuko, Tsuchihara, Katsuya, Esumi, Hiroyasu

“…Glucose is the most efficient energy source, and various cancer cells depend on glycolysis for energy production. For maintenance of survival and…”
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Abstract 3361: EGFR signaling regulates aerobic glycolysis in EGFR-mutated lung adenocarcinoma by Makinoshima, Hideki, Takita, Masahiro, Matsumoto, Shingo, Yagishita, Atsushi, Owada, Satoshi, Esumi, Hiroyasu, Tsuchihara, Katsuya

“…Abstract Recent accumulating evidences suggest that genetic mutations in tumor cells cause several unique metabolic phenotypes that are critical for cancerous…”
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Abstract 1133: Glucose deprivation-induced intracellular reactive oxygen species activates the PI3K-AKT axis by Owada, Satoshi, Shimoda, Yuko, Tsuchihara, Katsuya, Esumi, Hiroyasu

“…Abstract Glucose is the most efficient energy source and various cancer cells depend on glycolysis for their energy production. On the other hand, tumor…”
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Abstract CT213: Arctigenin, an antiausterity agent shows high safety and promising clinical response in phase I clinical trial in patient with gemcitabine-refractory pancreatic cancer by Esumi, Hiroyasu, Owada, Satoshi, Fujioka, Rumi, Tsuchihara, Katsuya, Ohtsu, Atsushi, Sato, Aihiro, Ikeda, Masafumi, Mochizuki, Nobuo, Kishino, Satoshi, Kawashima, Takanori, Yomoda, Satoshi

“…Abstract Cancer microenvironment is characterized by severe hypoxia and nutrient deprivation, especially glucose. Cancer depends largely on glycolysis for…”
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