Search Results - "Ovod, Vitaliy"

Age and amyloid effects on human central nervous system amyloid-beta kinetics by Patterson, Bruce W., Elbert, Donald L., Mawuenyega, Kwasi G., Kasten, Tom, Ovod, Vitaliy, Ma, Shengmei, Xiong, Chengjie, Chott, Robert, Yarasheski, Kevin, Sigurdson, Wendy, Zhang, Lily, Goate, Alison, Benzinger, Tammie, Morris, John C., Holtzman, David, Bateman, Randall J.

“…Objective Age is the single greatest risk factor for Alzheimer's disease (AD), with the incidence doubling every 5 years after age 65. However, our…”
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Acute sleep loss decreases CSF‐to‐blood clearance of Alzheimer's disease biomarkers by Liu, Haiyan, Barthélemy, Nicolas R., Ovod, Vitaliy, Bollinger, James G., He, Yingxin, Chahin, Samir L., Androff, Brendan, Bateman, Randall J., Lucey, Brendan P.

“…Introduction Sleep deprivation increases cerebrospinal fluid (CSF) amyloid beta (Aβ) and tau levels; however, sleep's effect on Aβ and tau in plasma is…”
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The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer's disease: a literature review by Brand, Abby L, Lawler, Paige E, Bollinger, James G, Li, Yan, Schindler, Suzanne E, Li, Melody, Lopez, Samir, Ovod, Vitaliy, Nakamura, Akinori, Shaw, Leslie M, Zetterberg, Henrik, Hansson, Oskar, Bateman, Randall J

“…The extracellular buildup of amyloid beta (Aβ) plaques in the brain is a hallmark of Alzheimer's disease (AD). Detection of Aβ pathology is essential for AD…”
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Diurnal patterns of soluble amyloid precursor protein metabolites in the human central nervous system by Dobrowolska, Justyna A, Kasten, Tom, Huang, Yafei, Benzinger, Tammie L S, Sigurdson, Wendy, Ovod, Vitaliy, Morris, John C, Bateman, Randall J

“…The amyloid-β (Aβ) protein is diurnally regulated in both the cerebrospinal fluid and blood in healthy adults; circadian amplitudes decrease with aging and the…”
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Cognitive impact of multidomain intervention and omega 3 according to blood Aβ42/40 ratio: a subgroup analysis from the randomized MAPT trial by Delrieu, Julien, Vellas, Bruno, Guyonnet, Sophie, Cantet, Christelle, Ovod, Vitaliy, Li, Yan, Bollinger, James, Bateman, Randall, Andrieu, Sandrine

“…Abstract Background In MAPT (Multidomain Alzheimer Preventive Trial), a cognitive effect of multidomain intervention (MI) was showed in non-demented subjects…”
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Predicting continuous amyloid PET values with CSF and plasma Aβ42/Aβ40 by Wisch, Julie K., Gordon, Brian A., Boerwinkle, Anna H., Luckett, Patrick H., Bollinger, James G., Ovod, Vitaliy, Li, Yan, Henson, Rachel L., West, Tim, Meyer, Mathew R., Kirmess, Kristopher M., Benzinger, Tammie L.S., Fagan, Anne M., Morris, John C., Bateman, Randall J., Ances, Beau M., Schindler, Suzanne E.

“…Introduction Continuous measures of amyloid burden as measured by positron emission tomography (PET) are being used increasingly to stage Alzheimer's disease…”
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Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers by Potter, Rachel, Patterson, Bruce W, Elbert, Donald L, Ovod, Vitaliy, Kasten, Tom, Sigurdson, Wendy, Mawuenyega, Kwasi, Blazey, Tyler, Goate, Alison, Chott, Robert, Yarasheski, Kevin E, Holtzman, David M, Morris, John C, Benzinger, Tammie L S, Bateman, Randall J

“…Alzheimer's disease (AD) is hypothesized to be caused by an overproduction or reduced clearance of amyloid-β (Aβ) peptide. Autosomal dominant AD (ADAD) caused…”
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High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis by Schindler, Suzanne E, Bollinger, James G, Ovod, Vitaliy, Mawuenyega, Kwasi G, Li, Yan, Gordon, Brian A, Holtzman, David M, Morris, John C, Benzinger, Tammie L.S, Xiong, Chengjie, Fagan, Anne M, Bateman, Randall J

“…OBJECTIVEWe examined whether plasma β-amyloid (Aβ)42/Aβ40, as measured by a high-precision assay, accurately diagnosed brain amyloidosis using amyloid PET or…”
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Head-to-Head Comparison of 8 Plasma Amyloid-β 42/40 Assays in Alzheimer Disease by Janelidze, Shorena, Teunissen, Charlotte E, Zetterberg, Henrik, Allué, José Antonio, Sarasa, Leticia, Eichenlaub, Udo, Bittner, Tobias, Ovod, Vitaliy, Verberk, Inge M W, Toba, Kenji, Nakamura, Akinori, Bateman, Randall J, Blennow, Kaj, Hansson, Oskar

“…Blood-based tests for brain amyloid-β (Aβ) pathology are needed for widespread implementation of Alzheimer disease (AD) biomarkers in clinical care and to…”
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Decreased Clearance of CNS β-Amyloid in Alzheimer's Disease by Mawuenyega, Kwasi G, Sigurdson, Wendy, Ovod, Vitaliy, Munsell, Ling, Kasten, Tom, Morris, John C, Yarasheski, Kevin E, Bateman, Randall J

“…Alzheimer's disease is hypothesized to be caused by an imbalance between β-amyloid (Aβ) production and clearance that leads to Aβ accumulation in the central…”
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Effect of sleep on overnight cerebrospinal fluid amyloid β kinetics by Lucey, Brendan P., Hicks, Terry J., McLeland, Jennifer S., Toedebusch, Cristina D., Boyd, Jill, Elbert, Donald L., Patterson, Bruce W., Baty, Jack, Morris, John C., Ovod, Vitaliy, Mawuenyega, Kwasi G., Bateman, Randall J.

“…Sleep disturbances are associated with future risk of Alzheimer disease. Disrupted sleep increases soluble amyloid β, suggesting a mechanism for sleep…”
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Amyloid β concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis by Ovod, Vitaliy, Ramsey, Kara N., Mawuenyega, Kwasi G., Bollinger, Jim G., Hicks, Terry, Schneider, Theresa, Sullivan, Melissa, Paumier, Katrina, Holtzman, David M., Morris, John C., Benzinger, Tammie, Fagan, Anne M., Patterson, Bruce W., Bateman, Randall J.

“…Cerebrospinal fluid analysis and other measurements of amyloidosis, such as amyloid-binding positron emission tomography studies, are limited by cost and…”
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Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques by Li, Yan, Schindler, Suzanne E., Bollinger, James G., Ovod, Vitaliy, Mawuenyega, Kwasi G., Weiner, Michael W., Shaw, Leslie M., Masters, Colin L., Fowler, Christopher J., Trojanowski, John Q., Korecka, Magdalena, Martins, Ralph N., Janelidze, Shorena, Hansson, Oskar, Bateman, Randall J.

“…To determine the diagnostic accuracy of a plasma Aβ42/Aβ40 assay in classifying amyloid PET status across global research studies using samples collected by…”
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Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS by Lucey, Brendan P., Liu, Haiyan, Toedebusch, Cristina D., Freund, David, Redrick, Tiara, Chahin, Samir L., Mawuenyega, Kwasi G., Bollinger, James G., Ovod, Vitaliy, Barthélemy, Nicolas R., Bateman, Randall J.

“…Objective In Alzheimer's disease, hyperphosphorylated tau is associated with formation of insoluble paired helical filaments that aggregate as neurofibrillary…”
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Amyloid-β efflux from the central nervous system into the plasma by Roberts, Kaleigh Filisa, Elbert, Donald L., Kasten, Tom P., Patterson, Bruce W., Sigurdson, Wendy C., Connors, Rose E., Ovod, Vitaliy, Munsell, Ling Y., Mawuenyega, Kwasi G., Miller-Thomas, Michelle M., Moran, Christopher J., Cross III, Dewitte T., Derdeyn, Colin P., Bateman, Randall J.

“…Objective The aim of this study was to measure the flux of amyloid‐β (Aβ) across the human cerebral capillary bed to determine whether transport into the blood…”
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Associations Between β-Amyloid Kinetics and the β-Amyloid Diurnal Pattern in the Central Nervous System by Lucey, Brendan P, Mawuenyega, Kwasi G, Patterson, Bruce W, Elbert, Donald L, Ovod, Vitaliy, Kasten, Tom, Morris, John C, Bateman, Randall J

“…Recent studies found that the concentration of amyloid-β (Aβ) fluctuates with the sleep-wake cycle. Although the amplitude of this day/night pattern attenuates…”
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Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques by Li, Yan, Schindler, Suzanne E., Bollinger, James G., Ovod, Vitaliy, Mawuenyega, Kwasi G, Weiner, Michael W., Leslie, Shaw M., Masters, Colin L., Fowler, Christopher J., Trojanowski, John Q., Korecka, Magdalena, Martins, Ralph N., Janelidze, Shorena, Hansson, Oskar, Bateman, Randall J.

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Human Central Nervous System (CNS) ApoE Isoforms Are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared with Plasma by Baker-Nigh, Alaina T., Mawuenyega, Kwasi G., Bollinger, James G., Ovod, Vitaliy, Kasten, Tom, Franklin, Erin E., Liao, Fan, Jiang, Hong, Holtzman, David, Cairns, Nigel J., Morris, John C., Bateman, Randall J.

“…The risk of Alzheimer's disease (AD) is highly dependent on apolipoprotein-E (apoE) genotype. The reasons for apoE isoform-selective risk are uncertain;…”
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The relationship of soluble p‐tau isoforms with brain amyloid and tau deposition in sporadic AD by Barthélemy, Nicolas R., Saef, Benjamin A., Li, Yan, Gordon, Brian A., He, Yingxin, Horie, Kanta, Sato, Chihiro, Ovod, Vitaliy, Benzinger, Tammie L.S., Morris, John C., Bateman, Randall J., Schindler, Suzanne E.

“…Background Hyperphosphorylated tau isoforms (p‐tau) in cerebrospinal fluid (CSF) and plasma represent promising measures to monitor Alzheimer disease (AD)…”
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CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer's disease by Barthélemy, Nicolas R, Saef, Benjamin, Li, Yan, Gordon, Brian A, He, Yingxin, Horie, Kanta, Stomrud, Erik, Salvadó, Gemma, Janelidze, Shorena, Sato, Chihiro, Ovod, Vitaliy, Henson, Rachel L, Fagan, Anne M, Benzinger, Tammie L S, Xiong, Chengjie, Morris, John C, Hansson, Oskar, Bateman, Randall J, Schindler, Suzanne E

“…Cerebrospinal fluid (CSF) amyloid-β peptide (Aβ)42/Aβ40 and the concentration of tau phosphorylated at site 181 (p-tau181) are well-established biomarkers of…”
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