Search Results - "Overwater, Iris E."

TORC1-dependent epilepsy caused by acute biallelic Tsc1 deletion in adult mice by Abs, Elisabeth, Goorden, Susanna M. I., Schreiber, Jadwiga, Overwater, Iris E., Hoogeveen-Westerveld, Marianne, Bruinsma, Caroline F., Aganović, Elvedin, Borgesius, Nils Z., Nellist, Mark, Elgersma, Ype

“…Objective Seizure development in tuberous sclerosis complex (TSC) correlates with the presence of specific lesions called cortical tubers. Moreover,…”
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A randomized controlled trial with everolimus for IQ and autism in tuberous sclerosis complex by Overwater, Iris E, Rietman, André B, Mous, Sabine E, Bindels-de Heus, Karen, Rizopoulos, Dimitris, ten Hoopen, Leontine W, van der Vaart, Thijs, Jansen, Floor E, Elgersma, Ype, Moll, Henriette A, de Wit, Marie-Claire Y

“…OBJECTIVETo investigate whether mammalian target of rapamycin inhibitor everolimus can improve intellectual disability, autism, and other neuropsychological…”
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Epilepsy in children with tuberous sclerosis complex: Chance of remission and response to antiepileptic drugs by Overwater, Iris E., Bindels‐de Heus, Karen, Rietman, André B., Hoopen, Leontine W., Vergouwe, Yvonne, Moll, Henriette A., Wit, Marie‐Claire Y.

“…Summary Objective To describe treatment and outcome of epilepsy in children with tuberous sclerosis complex (TSC). Methods Seventy‐one children with TSC and…”
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Sirolimus for epilepsy in children with tuberous sclerosis complex: A randomized controlled trial by Overwater, Iris E, Rietman, André B, Bindels-de Heus, Karen, Looman, Caspar W.N, Rizopoulos, Dimitris, Sibindi, Tafadzwa M, Cherian, Perumpillichira J, Jansen, Floor E, Moll, Henriëtte A, Elgersma, Ype, de Wit, Marie-Claire Y

“…OBJECTIVE:To investigate whether mammalian target of rapamycin complex 1 (mTORC1) inhibitors could reduce seizure frequency in children with tuberous sclerosis…”
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Everolimus for the treatment of refractory seizures associated with tuberous sclerosis complex (TSC): current perspectives by Overwater, Iris E, Rietman, André B, van Eeghen, Agnies M, de Wit, Marie Claire Y

“…Up to 90% of patients with tuberous sclerosis complex (TSC) have epilepsy, and in over half of patients seizure control cannot be achieved by regular…”
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Treatment of Cognitive Deficits in Genetic Disorders: A Systematic Review of Clinical Trials of Diet and Drug Treatments by van der Vaart, Thijs, Overwater, Iris E, Oostenbrink, Rianne, Moll, Henriëtte A, Elgersma, Ype

“…Knowing the underlying etiology of intellectual disability in genetic disorders holds great promise for developing targeted treatments. Although successful…”
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Author response: Sirolimus for epilepsy in children with tuberous sclerosis complex: A randomized controlled trial by de Wit, Marie-Claire Y, Overwater, Iris E

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Genotype and brain pathology phenotype in children with tuberous sclerosis complex by Overwater, Iris E, Swenker, Rob, van der Ende, Emma L, Hanemaayer, Kimberley Bm, Hoogeveen-Westerveld, Marianne, van Eeghen, Agnies M, Lequin, Maarten H, van den Ouweland, Ans Mw, Moll, Henriëtte A, Nellist, Mark, de Wit, Marie-Claire Y

“…Structural brain malformations associated with Tuberous Sclerosis Complex (TSC) are related to the severity of the clinical symptoms and can be visualized by…”
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Cortical dysplasia and autistic trait severity in children with Tuberous Sclerosis Complex: a clinical epidemiological study by Mous, Sabine E., Overwater, Iris E., Vidal Gato, Rita, Duvekot, Jorieke, ten Hoopen, Leontine W., Lequin, Maarten H., de Wit, Marie-Claire Y., Dieleman, Gwendolyn C.

“…Tuberous Sclerosis Complex (TSC) is characterized by a high prevalence of autism spectrum disorders (ASD). Little is known about the relation between cortical…”
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Counselling in tuberous sclerosis complex: A survey on content and satisfaction in the Netherlands by Hulshof, Hanna M., Brenner, Juliette, Overwater, Iris E., Wit, Marie-Claire de, Braun, Kees P.J., Jansen, Floor E.

“…Tuberous sclerosis complex (TSC) is a highly variable condition and its clinical features cannot reliably be predicted from the genotype. Counselling of…”
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Treatment of intractable epilepsy in tuberous sclerosis complex with everolimus is not yet evidence-based by Overwater, Iris E., Rietman, André B., Elgersma, Ype, de Wit, Marie-Claire Y.

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