Search Results - "Overstreet, Derek J."

Injectable hydrogels by Overstreet, Derek J., Dutta, Dipankar, Stabenfeldt, Sarah E., Vernon, Brent L.

“…Hydrogels are promising for a variety of medical applications due to their high water content and mechanical similarity to natural tissues. When made…”
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Extended Release of Bupivacaine from Temperature-Responsive PNDJ Hydrogels Improves Postoperative Weight-Bearing in Rabbits Following Knee Surgery by Overstreet, Derek J, Zdrale, Gabriel, McLaren, Alex C

“…Effective treatment of postoperative pain lasting for multiple days without opioids is an important clinical need. We previously reported analgesia lasting up…”
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In situ crosslinking temperature‐responsive hydrogels with improved delivery, swelling, and elasticity for endovascular embolization by Overstreet, Derek J., Lee, Elizabeth J., Pal, Amrita, Vernon, Brent L.

“…Endovascular embolization of cerebral aneurysms is a common approach for reducing the risk of often‐fatal hemorrhage. However, currently available materials…”
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Local antimicrobial delivery from temperature-responsive hydrogels reduces incidence of intra-abdominal infection in rats by Heffernan, John M., McLaren, Alex C., Overstreet, Derek J.

“…The objective of this study was to evaluate local antimicrobial delivery from temperature-responsive hydrogels for preventing infection in a rat model of…”
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Bioengineered Scaffolds for 3D Analysis of Glioblastoma Proliferation and Invasion by Heffernan, John M., Overstreet, Derek J., Le, Long D., Vernon, Brent L., Sirianni, Rachael W.

“…The invasion of malignant glioblastoma (GBM) cells into healthy brain is a primary cause of tumor recurrence and associated morbidity. Here, we describe a…”
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Extended Release of Bupivacaine from Temperature-responsive Hydrogels Provides Multi-day Analgesia for Postoperative Pain by Heffernan, John M, McLaren, Alex C, Glass, Christopher M, Overstreet, Derek J

“…A local anesthetic that provides analgesia lasting at least three days could significantly improve postoperative pain management. This study evaluated the…”
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In vivo evaluation of temperature‐responsive antimicrobial‐loaded PNIPAAm hydrogels for prevention of surgical site infection by Heffernan, John M., Overstreet, Derek J., Vernon, Brent L., McLemore, Ryan Y., Nagy, Tamas, Moore, Rex C., Badha, Vajra S., Childers, Erin P., Nguyen, Michael B., Gentry, Daniel D., Calara, Francis M., Saunders, W. Brian, Feltis, Tim, McLaren, Alex C.

“…Surgical site infections (SSIs) are a persistent clinical challenge. Local antimicrobial delivery may reduce the risk of SSI by increasing drug concentrations…”
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In situ forming, resorbable graft copolymer hydrogels providing controlled drug release by Overstreet, Derek J., Huynh, Richard, Jarbo, Keith, McLemore, Ryan Y., Vernon, Brent L.

“…In situ forming hydrogels are promising drug delivery vehicles due to their ease of delivery as liquids and their ability to be used in sites with irregular…”
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Temperature responsive hydrogels enable transient three-dimensional tumor cultures via rapid cell recovery by Heffernan, John M., Overstreet, Derek J., Srinivasan, Sanjay, Le, Long D., Vernon, Brent L., Sirianni, Rachael W.

“…Recovery of live cells from three‐dimensional (3D) culture would improve analysis of cell behaviors in tissue engineered microenvironments. In this work, we…”
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Bioresponsive Copolymers of Poly(N-isopropylacrylamide) with Enzyme-Dependent Lower Critical Solution Temperatures by Overstreet, Derek J, Dhruv, Harshil D, Vernon, Brent L

“…Novel thermoreversible copolymers of N-isopropylacrylamide (NIPAAm) with collagenase-sensitive solubility behavior were synthesized by radical polymerization…”
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Temperature-responsive PNDJ hydrogels provide high and sustained antimicrobial concentrations in surgical sites by Overstreet, Derek J., Badha, Vajra S., Heffernan, John M., Childers, Erin P., Moore, Rex C., Vernon, Brent L., McLaren, Alex C.

“…Local antimicrobial delivery is a promising strategy for improving treatment of deep surgical site infections (SSIs) by eradicating bacteria that remain in the…”
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In vitro susceptibility of Propionibacterium acnes to simulated intrawound vancomycin concentrations by Hosack, Luke W., Overstreet, Derek J., Lederman, Evan S.

“…There is convincing evidence supporting the prophylactic use of intrawound vancomycin powder in spinal fusion surgery and mounting evidence in the arthroplasty…”
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Temperature-Responsive Graft Copolymer Hydrogels for Controlled Swelling and Drug Delivery by Overstreet, Derek J., McLemore, Ryan Y., Doan, Brandon D., Farag, Amye, Vernon, Brent L.

“…Temperature-responsive graft copolymers of N-isopropylacrylamide and Jeffamine® M-1000 acrylamide were synthesized to provide controlled swelling without…”
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