Search Results - "Overman, Ross C."

Structural and binding characterization of the LacdiNAc-specific adhesin (LabA; HopD) exodomain from Helicobacter pylori by Paraskevopoulou, Vasiliki, Schimpl, Marianne, Overman, Ross C., Stolnik, Snow, Chen, Yajie, Nguyen, Linh, Winkler, G. Sebastiaan, Gellert, Paul, Klassen, John S., Falcone, Franco H.

“…Helicobacter pylori (H. pylori) uses several outer membrane proteins for adhering to its host's gastric mucosa, an important step in establishing and…”
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Biochemical and biophysical characterization of four EphB kinase domains reveals contrasting thermodynamic, kinetic and inhibition profiles by Overman, Ross C, Debreczeni, Judit E, Truman, Caroline M, McAlister, Mark S, Attwood, Teresa K

“…The Eph (erythropoietin-producing hepatocellular carcinoma) B receptors are important in a variety of cellular processes through their roles in cell-to-cell…”
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A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding by Pflug, Alexander, Schimpl, Marianne, Nissink, J Willem M, Overman, Ross C, Rawlins, Philip B, Truman, Caroline, Underwood, Elizabeth, Warwicker, Juli, Winter-Holt, Jon, McCoull, William

“…The activation loop (A-loop) plays a key role in regulating the catalytic activity of protein kinases. Phosphorylation in this region enhances the phosphoryl…”
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Discovery of N‑(4-{[5-Fluoro-7-(2-methoxyethoxy)­quinazolin-4-yl]amino}­phenyl)-2-[4-(propan-2-yl)‑1H‑1,2,3-triazol-1-yl]­acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors by Kettle, Jason G, Anjum, Rana, Barry, Evan, Bhavsar, Deepa, Brown, Crystal, Boyd, Scott, Campbell, Andrew, Goldberg, Kristin, Grondine, Michael, Guichard, Sylvie, Hardy, Christopher J, Hunt, Tom, Jones, Rhys D. O, Li, Xiuwei, Moleva, Olga, Ogg, Derek, Overman, Ross C, Packer, Martin J, Pearson, Stuart, Schimpl, Marianne, Shao, Wenlin, Smith, Aaron, Smith, James M, Stead, Darren, Stokes, Steve, Tucker, Michael, Ye, Yang

“…While the treatment of gastrointestinal stromal tumors (GISTs) has been revolutionized by the application of targeted tyrosine kinase inhibitors capable of…”
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Completing the structural family portrait of the human EphB tyrosine kinase domains by Overman, Ross C., Debreczeni, Judit E., Truman, Caroline M., McAlister, Mark S., Attwood, Teresa K.

“…The EphB receptors have key roles in cell morphology, adhesion, migration and invasion, and their aberrant action has been linked with the development and…”
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