Search Results - "Overgaard, MT"

Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel by Wang, Kaiqian, Holt, Christian, Lu, Jocelyn, Brohus, Malene, Larsen, Kamilla Taunsig, Overgaard, Michael Toft, Wimmer, Reinhard, Van Petegem, Filip

“…Calmodulin (CaM) represents one of the most conserved proteins among eukaryotes and is known to bind and modulate more than a 100 targets. Recently, several…”
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Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry by Crotti, Lia, Spazzolini, Carla, Nyegaard, Mette, Overgaard, Michael T, Kotta, Maria-Christina, Dagradi, Federica, Sala, Luca, Aiba, Takeshi, Ayers, Mark D, Baban, Anwar, Barc, Julien, Beach, Cheyenne M, Behr, Elijah R, Bos, J Martijn, Cerrone, Marina, Covi, Peter, Cuneo, Bettina, Denjoy, Isabelle, Donner, Birgit, Elbert, Adrienne, Eliasson, Håkan, Etheridge, Susan P, Fukuyama, Megumi, Girolami, Francesca, Hamilton, Robert, Horie, Minoru, Iascone, Maria, Jaimez, Juan Jiménez, Jensen, Henrik Kjærulf, Kannankeril, Prince J, Kaski, Juan P, Makita, Naomasa, Muñoz-Esparza, Carmen, Odland, Hans H, Ohno, Seiko, Papagiannis, John, Porretta, Alessandra Pia, Prandstetter, Christopher, Probst, Vincent, Robyns, Tomas, Rosenthal, Eric, Rosés-Noguer, Ferran, Sekarski, Nicole, Singh, Anoop, Spentzou, Georgia, Stute, Fridrike, Tfelt-Hansen, Jacob, Till, Jan, Tobert, Kathryn E, Vinocur, Jeffrey M, Webster, Gregory, Wilde, Arthur A M, Wolf, Cordula M, Ackerman, Michael J, Schwartz, Peter J

“…Abstract Aims Calmodulinopathy due to mutations in any of the three CALM genes (CALM1–3) causes life-threatening arrhythmia syndromes, especially in young…”
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Molecular Phenotyping of Human Endometrium Distinguishes Menstrual Cycle Phases and Underlying Biological Processes in Normo-Ovulatory Women by Talbi, S, Hamilton, A. E, Vo, K. C, Tulac, S, Overgaard, M. T, Dosiou, C, Le Shay, N, Nezhat, C. N, Kempson, R, Lessey, B. A, Nayak, N. R, Giudice, L. C

“…Histological evaluation of endometrium has been the gold standard for clinical diagnosis and management of women with endometrial disorders. However, several…”
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Proteolytic degradation of IGF-binding protein (IGFBP)-2 in equine ovarian follicles: involvement of pregnancy-associated plasma protein-A (PAPP-A) and association with dominant but not subordinated follicles by Gerard, N, Delpuech, T, Oxvig, C, Overgaard, MT, Monget, P

“…In the ovary of mammalian species, terminal follicular growth is accompanied by a decrease in intrafollicular levels of IGF-binding protein-2 (IGFBP-2) and…”
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Pregnancy-Associated Plasma Protein A as a Marker of Acute Coronary Syndromes by Bayes-Genis, Antoni, Conover, Cheryl A, Overgaard, Michael T, Bailey, Kent R, Christiansen, Michael, Holmes, David R, Virmani, Renu, Oxvig, Claus, Schwartz, Robert S

“…PAPP-A, a marker of Down's syndrome, may also be a useful marker of unstable coronary-artery plaques. Patients with acute coronary syndromes are at…”
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Dickkopf-1, an Inhibitor of Wnt Signaling, Is Regulated by Progesterone in Human Endometrial Stromal Cells by Tulac, Suzana, Overgaard, Michael T., Hamilton, Amy E., Jumbe, Nelson L., Suchanek, Ernest, Giudice, Linda C.

“…Context: Some members of the Wnt family, including ligands, receptors, inhibitors, and signaling components, are expressed in human endometrium. Dickkopf-1…”
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Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development by Conover, Cheryl A, Bale, Laurie K, Overgaard, Michael T, Johnstone, Edward W, Laursen, Ulla H, Füchtbauer, Ernst-Martin, Oxvig, Claus, van Deursen, Jan

“…Pregnancy-associated plasma protein A (PAPPA) is a metzincin superfamily metalloproteinase in the insulin-like growth factor (IGF) system. PAPPA increases IGF…”
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The Insulin-Like Growth Factor (IGF)-Dependent IGF Binding Protein-4 Protease Secreted by Human Fibroblasts Is Pregnancy-Associated Plasma Protein-A by Lawrence, James B., Oxvig, Claus, Overgaard, Michael T., Sottrup-Jensen, Lars, Gleich, Gerald J., Hays, Lara G., Yates, John R., Conover, Cheryl A.

“…Proteolytic cleavage of the six known insulin-like growth factor binding proteins (IGFBPs) is a powerful means of rapid structure and function modification of…”
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Pregnancy‐associated plasma protein‐A (PAPP‐A) cleaves insulin‐like growth factor binding protein (IGFBP)‐5 independent of IGF: implications for the mechanism of IGFBP‐4 proteolysis by PAPP‐A by Laursen, Lisbeth S., Overgaard, Michael T., Søe, Rikke, Boldt, Henning B., Sottrup-Jensen, Lars, Giudice, Linda C., Conover, Cheryl A., Oxvig, Claus

“…Pregnancy‐associated plasma protein‐A (PAPP‐A) has recently been identified as the proteinase responsible for cleavage of insulin‐like growth factor binding…”
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Relationship among pregnancy associated plasma protein-A levels, clinical characteristics, and coronary artery disease extent in patients with chronic stable angina pectoris by Cosin-Sales, Juan, Kaski, Juan Carlos, Christiansen, Michael, Kaminski, Paul, Oxvig, Claus, Overgaard, Michael T., Cole, Della, Holt, David W.

“…Aims To assess, in chronic stable angina (CSA) patients, the relationship among clinical characteristics and cardiovascular risk factors, extent of coronary…”
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Pregnancy-associated Plasma Protein-A2 (PAPP-A2), a Novel Insulin-like Growth Factor-binding Protein-5 Proteinase by Overgaard, Michael T., Boldt, Henning B., Laursen, Lisbeth S., Sottrup-Jensen, Lars, Conover, Cheryl A., Oxvig, Claus

“…A novel metalloproteinase with similarity to pregnancy-associated plasma protein-A (PAPP-A), which we denoted PAPP-A2, has been identified. Through expression…”
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The IGF-1 receptor inhibitor picropodophyllin potentiates the anti-myeloma activity of a BH3-mimetic by Bieghs, Liesbeth, Lub, Susanne, Fostier, Karel, Maes, Ken, Van Valckenborgh, Els, Menu, Eline, Johnsen, Hans E, Overgaard, Michael T, Larsson, Olle, Axelson, Magnus, Nyegaard, Mette, Schots, Rik, Jernberg-Wiklund, Helena, Vanderkerken, Karin, De Bruyne, Elke

“…The ABT-analogous 737, 263 and 199 are BH3 mimetics showing potent anti-myeloma (MM) activity, but only on defined molecular subgroups of MM patients…”
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Pregnancy-associated plasma protein A and its endogenous inhibitor, the proform of eosinophil major basic protein (proMBP), are related to complex stenosis morphology in patients with stable angina pectoris by COSIN-SALES, Juan, CHRISTIANSEN, Michael, KAMINSKI, Paul, OXVIG, Claus, OVERGAARD, Michael T, COLE, Della, HOLT, David W, KASKI, Juan Carlos

“…The metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) has been implicated in coronary plaque disruption. Its endogenous inhibitor, the proform…”
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Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin by Boldt, H B, Overgaard, M T, Laursen, L S, Weyer, K, Sottrup-Jensen, L, Oxvig, C

“…The bioavailability of insulin-like growth factor (IGF)-I and -II is controlled by six IGF-binding proteins (IGFBPs 1-6). Bound IGF is not active, but…”
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Cytokine stimulation of pregnancy-associated plasma protein A expression in human coronary artery smooth muscle cells: inhibition by resveratrol by Conover, Cheryl A, Bale, Laurie K, Harrington, Sean C, Resch, Zachary T, Overgaard, Michael T, Oxvig, Claus

“…Through specific cleavage of proteins that bind and inhibit insulin-like growth factor-I (IGF-I), pregnancy-associated plasma protein-A (PAPP-A) enhances local…”
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Pregnancy-Associated Plasma Protein-A Is Involved in Insulin-Like Growth Factor Binding Protein-2 (IGFBP-2) Proteolytic Degradation in Bovine and Porcine Preovulatory Follicles: Identification of Cleavage Site and Characterization of IGFBP-2 Degradation by MONGET, Philippe, MAZERBOURG, Sabine, DELPUECH, Thierry, MAUREL, Marie-Christine, MANIERE, Sébastien, ZAPF, Jürgen, LALMANACH, Gilles, OXVIG, Claus, OVERGAARD, Michael T

“…In mammalian ovaries, terminal follicular growth is accompanied by a decrease in levels of intrafollicular insulin-like growth factor binding protein-2…”
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Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity. Reversible adhesion is mediated by two neighboring short consensus repeats by Laursen, Lisbeth S, Overgaard, Michael T, Weyer, Kathrin, Boldt, Henning B, Ebbesen, Peter, Christiansen, Michael, Sottrup-Jensen, Lars, Giudice, Linda C, Oxvig, Claus

“…The activities of insulin-like growth factor (IGF)-I and -II are regulated by IGF-binding proteins (IGFBPs). Cleavage of IGFBP-4 by the metalloproteinase…”
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Pregnancy-Associated Plasma Protein A Gene Expression as a Target of Inflammatory Cytokines by Resch, Zachary T, Chen, Bing-Kun, Bale, Laurie K, Oxvig, Claus, Overgaard, Michael T, Conover, Cheryl A

“…Pregnancy-associated plasma protein A (PAPP-A) cleaves IGF-binding protein-4 (IGFBP-4) and appears to enhance local IGF bioavailability in response to injury…”
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Identification and regulation of the IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: Evidence for paracrine regulation of IGF-II bioavailability in the placental bed during human implantation by GIUDICE, L. C, CONOVER, C. A, OVERGAARD, M. T, OXVIG, C, BALE, L, FAESSEN, G. H, ILG, K, SUN, I, IMANI, B, SUEN, L.-F, IRWIN, J. C, CHRISTIANSEN, M

“…The IGF family plays an important role in implantation and placental physiology. IGF-II is abundantly expressed by placental trophoblasts, and IGF binding…”
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Expression of Recombinant Human Pregnancy-associated Plasma Protein-A and Identification of the Proform of Eosinophil Major Basic Protein as Its Physiological Inhibitor by Overgaard, Michael T., Haaning, Jesper, Boldt, Henning B., Olsen, Inger M., Laursen, Lisbeth S., Christiansen, Michael, Gleich, Gerald J., Sottrup-Jensen, Lars, Conover, Cheryl A., Oxvig, Claus

“…Pregnancy-associated plasma protein-A (PAPP-A), originally known from human pregnancy serum, has recently been demonstrated to be a metzincin superfamily…”
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